The Resistance Arteries: Integration of the Regulatory Pathways / Edition 1

by William Halpern, John A. Bevan, Joseph Brayden, Harriet Dustan, Mark Nelson

Overview

The Resistance Arteries is focused on the general issue of the regulatory pathways in resistance arteries and comprises a selection of timely overviews and up-to-date research studies presented at the 4th International Symposium on Resistance Arteries held at the University of Vermont in January, 1994. These small vessels act as major controllers of blood pressure, blood flow, and its distribution, and are involved in a variety of pathological conditions.

The book is divided into five themes which address intra- and extracellular interactions, and membrane receptor pathways using diverse vascular beds such as the brain, heart, lung, kidney, and skin. Basic physiological studies examine growth factors, endothelium-derived nitric oxide, the impacts of flow and stretch, myogenic mechanisms, calcium regulation by protein kinase C, and signal transduction pathways. Much of the research was performed on human tissue to better elucidate vascular alterations of function and morphology in hypertension, atherosclerosis, and ischaemia.

Product Details

ISBN-13:	9780896033030
Publisher:	Springer-Verlag New York, LLC
Publication date:	10/19/1994
Series:	Experimental Biology and Medicine , #26
Edition description:	1995
Pages:	372
Product dimensions:	6.20(w) x 9.20(h) x 1.10(d)

Table of Contents

Protein Kinase C (PKC) Activation Lowers the Calcium Requirement for Cerebral Artery Myogenic Tone.- Distension Influences Responses to Agonists and Potassium in Several Types of Small Artery.-—-Toxin Permeabilization of Rat Mesenteric Small Arteries and Effects of Stretch.- Tension Development, Myosin Light Chain Phosphorylation and Changes in Intracellular Free [Ca2+]i Induced by—1- and—2- Adrenoceptor Agonists.- Vasopressin V1-Receptor Assay in Rat Small Mesenteric Arteries.- Protein Kinase C and Contraction of Vascular Smooth Muscle.- The Sarcoplasmic Reticulum Modulates Ca2+-Dependent Vasoconstriction.- Two Kinds of Spatially Separated Caffeine-Sensitive Calcium Stores in Smooth Muscle Cells From Guinea-Pig Mesenteric Artery.- Noradrenaline-Induced Calcium Inflow Appears Not Mediated by Receptor-Operated Calcium Channels in Rat Mesenteric Small Arteries.- Inward Rectifier Potassium Channels in Resistance Arteries.- Reduction of Delayed Rectifier K+ Current in Rat Pulmonary Artery Cells During Chronic Hypoxia.- Adenosine Activates Potassium Channels in Porcine Coronary Arterial Myocytes.- Hypoxia and Adenosine Inhibit Myogenic Reactivity by Activating ATP-Sensitive Potassium Channels.- Flow-Induced Relaxation of the Rabbit Facial Vein: Role of Endothelium and Subendothelial Tissues.- Exercise Training Augments EDRF (Nitric Oxide) Synthesis in Skeletal Muscle Arterioles.- EDNO of Venular Origin Can Influence Arteriolar Diameter.- Conducted Vasomotion in Isolated Arterioles: Evidence for Multiple Cellular Mechanisms.- Nitric Oxide and Vasoactive Intestinal Peptide as Dual Mediators of Neurogenic Relaxation in the Sheep Middle Cerebral Artery.- Vascular Remodeling in Hypertension: Its Prevalence and Possible Mechanism.- K+(ATP) Channels in Neonatal PulmonaryVessels During Normal Development and Chronic Hypoxia.- The Effect of Platelet-Derived Growth Factor on Tone and [Ca2+]i in Vascular Smooth Muscle.- Up/Down: A New Method for Determining Agonist Properties.- A Technique for Studying Physiologically Induced Conducted Responses In-Situ.- Confocal Myography: Applications for the Study of Resistance Arteries.- Stroke Related Alterations in the Cerebrovasculature of spSHR Associated with the Loss of Pressure Dependent Constriction.- The Vascular Ornithine Decarboxylase/Polyamine System in Deoxycorticosterone Acetate-Salt Hypertension.- Small Artery Function in Streptozoin-Induced Diabetic Rats.- Contractile Responses of Mesenteric Resistance Arteries to Bay K 8644 in Mineralocorticoid-Salt Hypertension.- Does Intracellular pH Affect Vascular Tone?.- Effect of Antihypertensive Treatment on Structure and Function of Resistance Arteries in Essential Hypertensive Patients.- Resistance Vessel Structure in Essential Hypertension.- Hypercholesterolaemia and Vascular Function.- Effect of Chronic Ischemia on Human Small Arteries.- Coronary Microvascular—-Adrenoceptor Subtypes and Crystalloid Cardioplegia.- List of Participants.