The Pharmacology of Sleep / Edition 1

by Anthony Kales, J. Adrien, F. Albani, A. Baruzzi, M. Berger

Overview

The last four decades have witnessed considerable advances in our knowledge of the pharmacology of sleep. Both basic and clinical pharmacology have made major contributions toward our current understanding of the complex mechanisms of sleep and wakefulness. In addition, these advances in our understanding of the pharmacology of sleep have benefited the treatment of sleep disorders and various neurologic and psychiatric conditions. This volume is organized into three different parts. The first is a review of the basic mechanisms of sleep and wakefulness and the chronobiology of sleep. The second part reviews the basic pharmacology of the various neuro­ transmitter systems involved in sleep and wakefulness, while the third is clinically oriented and focuses on the effects of a variety of drugs on sleep and wakefulness. The initial part begins with a historical review of the hypotheses of the mechanisms of sleep, evolving from passive to active regulation, and concepts involving sleep-related neurotransmitters and other sleep factors. Then regulation of sleep and wakefulness is discussed in terms of homeostatic, circadian, and ultradian processes. Also discussed is the fact that sleep homeostasis is not disrupted by the administration of hypnotic drugs. This part also reviews time-dependent properties of pharmacologic agents in relation to endogenous biologic rhythms and more specifically to chrono­ pharmacologic changes.

Product Details

ISBN-13:	9783540589617
Publisher:	Springer Berlin Heidelberg
Publication date:	12/11/1995
Series:	Handbook of Experimental Pharmacology , #116
Edition description:	1995
Pages:	583
Product dimensions:	6.10(w) x 9.25(h) x 0.36(d)

About the Author

Kales, Anthony, MD (Pennsylvania State Univ)

The contributors represent the specialties of neurology, psychiatry, pharmacology, chronobiology, and sleep research. Most are from universities in Europe, with some in the U.S. Institutions prominently represented include Univ of Bologna, Univ of Pisa, Athens Univ, Pennsylvania State Univ, and Univ of Chicago.

Table of Contents

1 Evolution of Concepts of Mechanisms of Sleep.- 2 Principles of Sleep Regulation: Implications for the Effect of Hypnotics on Sleep.- 3 Principles of Chronopharmacology and the Sleep-Wake Rhythm.- 4 Pharmacology of the Catecholaminergic System.- 5 The Serotoninergic System and Sleep-Wakefulness Regulation.- 6 Pharmacology of the Histaminergic System.- 7 Pharmacology of the Cholinergic System.- 8 Pharmacology of the GABAergic/Benzodiazepine System.- 9 Pharmacology of the CNS Peptides.- 10 Hormones and Sleep.- 11 Pharmacology of the Adenosine System.- 12 Methodological Issues in Pharmacological Studies of Sleep.- 13 Hypnotic Drugs.- 14 Anxiolytic Drugs.- 15 Stimulant Drugs.- 16 Neuroleptics, Antihistamines and Antiparkinsonian Drugs: Effects on Sleep.- 17 Antidepressant and Antimanic Drugs.- 18 Anticonvulsant Drugs.- 19 Mechanisms of Benzodiazepine Drug Dependence.- 20 Sleep Disturbances as Side Effects of Therapeutic Drugs.

Editorial Reviews

Reviewer: Ruzica K. Ristanovic, MD (Rush University Medical Center)
Description: This long-awaited book on pharmacology of sleep incorporates the contributions of a variety of experts (neurologists, psychiatrists, pharmacologists, chronobiologists, and scientists), most from universities in Europe, with some from the U.S.
Purpose: The purpose is to present the state-of-the-art of the pharmacology of sleep. It is organized in three sections: (1) basic mechanisms of sleep and wakefulness; (2) basic pharmacology of neurotransmitters involved in sleep and wakefulness; and (3) clinical applications with a focus on the effects of drugs on sleep. Such a comprehensive review of the pharmacology of sleep enables clinicians to treat sleep disorders, and it also provides neuroscientists with important information. The book meets its overall objective.
Audience: Targeted especially for sleep disorder specialists and neuroscientists involved in sleep research, this book will be useful to other physicians (neurologists, psychiatrists) and fellows specializing in sleep medicine in a variety of settings. Contributors are credible in the subject matter. The editor, also contributor, is a recognized authority in the field.
Features: This book includes a reasonable number of tables and graphs. A rare chapter was underillustrated. The references are extensive and up-to-date. In-depth coverage of specific clinically important topics such as sleep disturbances as side effects of therapeutic drugs is especially useful for practicing physicians.
Assessment: This is a very useful book for sleep disorder specialists, neurologists, psychiatrists, and other physicians as well as neuroscientists involved in sleep research. It combines up-to-date information on fundamental mechanisms of sleep and wakefulness, pharmacology of neurotransmitters involved in regulation of states of vigilance, and clinical pharmacology of sleep (hypnotics, stimulants, other drugs, and sleep). This book fills the void and the educational needs of professionals in the field of sleep medicine and research.

Doody's Review Service

3 Stars from Doody

This long-awaited book on pharmacology of sleep incorporates the contributions of a variety of experts (neurologists, psychiatrists, pharmacologists, chronobiologists, and scientists), most from universities in Europe, with some from the U.S. The purpose is to present the state-of-the-art of the pharmacology of sleep. It is organized in three sections: (1) basic mechanisms of sleep and wakefulness; (2) basic pharmacology of neurotransmitters involved in sleep and wakefulness; and (3) clinical applications with a focus on the effects of drugs on sleep. Such a comprehensive review of the pharmacology of sleep enables clinicians to treat sleep disorders, and it also provides neuroscientists with important information. The book meets its overall objective. Targeted especially for sleep disorder specialists and neuroscientists involved in sleep research, this book will be useful to other physicians (neurologists, psychiatrists) and fellows specializing in sleep medicine in a variety of settings. Contributors are credible in the subject matter. The editor, also contributor, is a recognized authority in the field. This book includes a reasonable number of tables and graphs. A rare chapter was underillustrated. The references are extensive and up-to-date. In-depth coverage of specific clinically important topics such as sleep disturbances as side effects of therapeutic drugs is especially useful for practicing physicians. This is a very useful book for sleep disorder specialists, neurologists, psychiatrists, and other physicians as well as neuroscientists involved in sleep research. It combines up-to-date information on fundamental mechanisms of sleep and wakefulness, pharmacology ofneurotransmitters involved in regulation of states of vigilance, and clinical pharmacology of sleep (hypnotics, stimulants, other drugs, and sleep). This book fills the void and the educational needs of professionals in the field of sleep medicine and research.

Ruzica K. Ristanovic