The Parathyroids: Basic and Clinical Concepts

by John P. Bilezikian MD (Editor), Robert Marcus MD (Editor), Michael A. Levine (Editor)

Overview

Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians.

Key Features
* Offers objective and authoritative reviews on controversial clinical issues
* Written by world experts on parathyroid hormone and its disorders
* Superb, state-of-the-art compendium in one convenient volume
* Bridges basic science of parathyroid hormone to major clinical disorders
* Practical information on clinical management of parathyroid hormone disorders

Product Details

ISBN-13:	9780080525778
Publisher:	Elsevier Science
Publication date:	07/21/2001
Sold by:	Barnes & Noble
Format:	eBook
Pages:	881
File size:	27 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. John P. Bilezikian, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians&Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians&Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach.
Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education,&Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly&Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone&Mineral Research in 2000-2001.
Dr. Michael A. Levine is Chief of Endocrinology and Diabetes and Director of the Center for Bone Health at The Children’s Hospital of Philadelphia. Dr. Levine holds the Lester Baker Endowed Chair and is Professor of Pediatrics and Medicine at the University of Pennsylvania Perelman School of Medicine. Dr. Levine’s research focuses on the genetic basis of disorders of bone and mineral metabolism and complements his clinical expertise in endocrine diseases that affect bone and mineral metabolism. His approach is to apply molecular and genetic tools to analyze the basis of altered hormone action, particularly in G protein-coupled signal transduction systems that affect growth and development. He has identified or contributed to the molecular basis of several inherited disorders of bone and mineral metabolism, including familial hypoparathyroidism, pseudohypoparathyroidism, cherubism, and the McCune Albright syndrome. His research interests now extend to the molecular events that control embryological development of the parathyroid glands and genetic modifiers of vitamin D action.

Table of Contents

Basic Elements of the Parathyroid System
Embryology, Anatomy, and Pathology
Parathyroid Hormone: Gene Structure, Biosynthesis, Metabolism
Parathyroid Hormone-related Protein: Gene Structure, Biosynthesis, Metabolism
Structure-function Analysis of PTH and PTHRP
Receptors for Parathyroid Hormone and PTHRP: Signaling and Regulation
Nuclear targeting: Signaling for PTHRP
Signal Transduction of PTH and PTHRP
Receptors and Signaling for Calcium Ion
Immunoassays for PTH and PTHRP: Clinical Applications
Physiological Aspects of the Parathyroids
Physiology of Calcium Homeostasis
Anabolic and Catabolic Effects of Parathyroid Hormone on Bone: Interaction with Growth Factors
Cellular Actions of Parathyroid Hormone on Osteoblast and Osteoclast Differentiation
Physiological Actions of PTH and PTHRP I: Skeletal Actions
Physiological Actions of PTH and PTHRP II: Renal Actions
Physiological Actions of PTH and PTHRP III: Chondrocyte, Tooth, and Bone Development
Physiological Actions of PTH and PTHRP IV: Vascular and Cardiovascular, Neurological Actions
Physiological Actions of PTH and PTHRP V: Mammary, Reproductive, Epidermal, and Pancreatic Tissue - PTH and PTHRP as Polyhormones
Clinical Aspects Primary Hyperparathyroidism
Normal and Abnormal Growth of Parathyroid Cells
Molecular Genetics of Primary Hyperparathyroidism
Clinical Presentation of Primary Hyperparathyroidism: US
Clinical Presentation of Primary Hyperparathyroidism: Europe
Clinical Presentation of Primary Hyperparathyroidism: India, Brazil, China
Clinical Course of Primary Hyperparathyroidism
Bone Turnover in Primary Hyperparathyroidism
Cytokines in Primary Hyperparathyroidism
Histomorphometric Analysis of Bone in Primary Hyperparathyroidism
Nephrolithiasis in Primary Hyperparathyroidism
Guidelines for the Medical or Surgical Management of Primary Hyperparathyroidism
Medical Management of Primary Hyperparathyroidism
Preoperative Localization of Parathyroid Tissue in Primary Hyperparathyroidism
Surgical Management of Primary Hyperparathyroidism
Ectopic Locations of Parathyroid Glands
Parathyroid Carcinoma
Acute Primary Hyperparathyroidism
Multiple Endocrine Neoplasia Type I
Multiple Endocrine Neoplasia Type II
Familial Forms of Primary Hyperparathyroidism
Familial Hypocalciuric Hypercalce
Secondary Hyperparathyroidism
Parathyroids in Renal Disease: Pathophysiology
Hyperparathyroidism in Renal Failure: Clinical Features, Diagnosis, and Management
Special Considerations
Evaluation of the Hypercalcemic Patient: Differential Diagnosis
Hypercalce Due to PTHRP
Other Local and Ectopic Secretion Syndromes Associated with Hypercalce
Jansen's Disease
Acute Management of Hypercalce
Primary Hyperparathyroidism and Other Causes of Hypercalce in Children and Adolescents
The Hypoparathyroid States
Hypoparathyroidism in Differential Diagnosis of Hypocalce
Parathyroid Function in Magnesium Deficiency
Molecular Genetics of Hypoparathyroidism
Autoimmune Aspects of Hypoparathyroidism
Pseudohypoparathyroidism: Clinical, Biochemical, and Molecular features
Treatment of Hypoparathyroidism
The Parathyroids in Osteoporosis
Parathyroid Function in the Normal Aging Process
Parathyroid Function and Responsiveness in Osteoporosis
Parathyroid Hormone and Growth Hormone in the Treatment of Osteoporosis

Editorial Reviews

4 Stars! from Doody

This book contains a comprehensive examination of the physiology and biochemistry of parathyroid hormone and a discussion of diseases of the parathyroid. The purpose is to summarize all of the recent advances in the area of the parathyroid glands. It discusses the basic and clinical concepts of the parathyroid in detail. This is an important and timely review of this area. This book is written for students, teachers, practitioners, and individuals working in the area of calcium research. It is a useful book for endocrinologists in particular. The authors and contributors are very solid and credible in their respective areas. This book has numerous illustrations, graphs, charts, and tables appropriate for this text. It contains extensive up-to-date references. The unique feature of this book is its excellent division into basic concepts followed by clinical concepts. This is an excellent textbook reviewing basic concepts and clinical concepts regarding the parathyroids. It is a most useful textbook for students, teachers, practitioners, or individuals working in the area of calcium metabolism. The library, bookstore, and individuals could purchase this text. It is a tremendous summary of all that is currently known about the parathyroids.

Maria M. Byrne

It represents a significant contribution to the field,and likely will continue to do so for many editions.

Bart L. Clarke

A text that provides a comprehensive examination of basic and clinical concepts of the parathyroids, for students, teachers, practitioners, and investigators of the field. Section I, Basic Concepts of the Parathyroids, includes subsections on anatomy and physiology (7 chapters); parathyroid hormone--structure, function, receptors, mechanisms of action (9 chapters); and causes and management of hypercalcemia due to parathyroid hormone-related protein and other factors (6 chapters). Section II, Clinical Concepts of the Parathyroids, includes subsections on the hyperparathyroid states (18 chapters); the parathyroids in the reactive hyperparathyroidism of renal disease (2 chapters); the hyperparathyroid states (5 chapters); and the parathyroids in other disorders of mineral metabolism (4 chapters). Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Bart L. Clarke, MD (Mayo Clinic)
Description: This book covers basic and clinical aspects of the parathyroid glands, describing advances in the physiology, pathology, and molecular biology of the parathyroid glands, primary and secondary hyperparathyroidism, clinical syndromes related to the parathyroid glands, hypoparathyroidism, and the role of the parathyroid glands in osteoporosis. The first edition was published in 1994.
Purpose: The purpose is to summarize the body of knowledge about the parathyroid glands accumulated over the last 30 years. This is a worthy objective as the field has advanced rapidly over the last 10 years, with many new discoveries in the last decade. The book meets the authors' objectives extremely well.
Audience: This book is targeted at individuals interested in the parathyroid glands, including endocrinologists, rheumatologists, nephrologists, clinical and basic researchers, subspecialty fellows, residents, and medical students. Anyone with an interest in metabolic bone disease would find this text helpful. The editors and authors are internationally known experts in this area, having made most of the major contributions to our current knowledge of the parathyroid glands.
Features: Current knowledge of the molecular biology, physiology, and pathology of the parathyroid glands, physiology of calcium homeostasis, clinical primary hyperparathyroidism, clinical syndromes related to the parathyroid glands, and clinical aspects of hypoparathyroidism is described extremely well. Secondary hyperparathyroidism is covered less well, as this is described in much greater detail in other textbooks. A very nice section on the role of the parathyroid glands in osteoporosis concludes the book, covering the state of knowledge of this area extremely well. Most of the figures in the book are black and white, but a number of interesting color plates are included.
Assessment: This book has no significant competitors in the published literature. It focuses solely on the parathyroid glands, and not more broadly on osteoporosis or metabolic bone disorders. It represents a significant contribution to the field, and likely will continue to do so for many editions. As a second edition, this book contains much new information acquired since the first edition was published in 1994, and chapters have been rewritten, expanded, and added to reflect these new discoveries. This book is highly recommended to those with an interest in the parathyroid glands.

Doody's Review Service

"...a comprehensive source of information that most endocrinologists will want to have on their bookshelves."
-TRENDS IN ENDOCRINOLOGY AND METABOLISM (April 2003)
"It represents a significant contribution to the field, and likely will continue to do so for many editions."
—Bart L. Clarke, Mayo Clinic, for DOODY PUBLISHING REVIEWS (2002)

From the Publisher