The Newborn Brain: Neuroscience and Clinical Applications

by Hugo Lagercrantz (Editor), M. A. Hanson (Editor), Laura R. Ment (Editor), Donald M. Peebles (Editor)

Overview

Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.

Product Details

ISBN-13:	9780511846472
Publisher:	Cambridge University Press
Publication date:	01/07/2010
Sold by:	Barnes & Noble
Format:	eBook
File size:	8 MB

About the Author

Hugo Lagercrantz is Professor of Pediatrics at the Karolinska Institute and Clinical Consultant at the Astrid Lindgren Children's Hospital, Stockholm, Sweden.
M. A. Hanson is Director of the Institute of Developmental Sciences, Director of the Developmental Origins of Health and Disease Division and the British Heart Foundation Professor of Cardiovascular Science at the University of Southampton, UK.
Laura R. Ment is Professor of Pediatrics and Neurology at Yale University School of Medicine, New Haven, CT, USA.
Donald M. Peebles is Professor of Obstetrics at the Department of Obstetrics and Gynaecology, University College London School of Medicine, London, UK.

Table of Contents

List of contributors; 1. Reflections on the origins of the human brain Jean-Pierre Changeux; Part I. Making of the Brain: 2. The molecular basis of central nervous system development Ola Hermanson and Urban Lendahl; Historical box 1; 3. Holoprosencephaly and microcephaly vera: perturbations of proliferations Verne S. Caviness Jr, Pradeep G. Bhide and Richard S. Nowakowski; Historical box 2; 4. Neuronal migration Sandrine Passemard, Angela M. Kaindl, Virginia Leverche, Pascal Dournaud and Pierre Gressens; 5. Synaptogenesis in the neocortex of the newborn: the ultimate frontier for individuation? Jean-Pierre Bourgeois; 6. Neurotrophic factors in brain development Thomas Ringstedt; Historical box 3; 7. Neurotransmitters and neuromodulators Eric Herlenius and Hugo Lagercrantz; Historical box 4; 8. Glial cell biology Arne Schousboe and Helle S. Waagepetersen; Part II. Sensory Systems and Behavior: 9. Development of the somatosensory system Sandra Rees, David Walker and Ernest Jennings; 10. Principles of endogenous and sensory activity-dependent brain development: the visual system Anna A. Penn and Carla J. Shatz; Historical box 5; 11. Fetal and neonatal development of the auditory system S. Allen Counter; 12. Newborn behaviour and perception Elena V. Kushnerenko and Mark H. Johnson; Part III. Radiological and Neurophysiological Investigation: 13. Imaging the infant brain Mary A. Rutherford; 14. Electroencephalography and amplitude-integrated EEG Lena Hellström-Westas and Ingemar Rosén; 15. Emergence of spontaneous and evoked EEG activity in the human brain Sampsa Vanhatalo and Kai Kaila; Part IV. Clinical Aspects: 16. Perinatal infections and brain injuries Donald Peebles; 17. Hypoxic-ischemic encephalopathy Deanna L. Taylor, Grisha Pirianov, A. David Edwards and Henrik Hagberg; 18. Clinical assessment and therapeutic interventions for hypoxic-ischemic encephalopathy in the full-term infant Andrew Whitelaw and Marianne Thoresen; 19. Clinical aspects of brain injury in the preterm infant Michael Weindling; Part V. Follow-Up: 20. Injury and recovery in the developing brain Koray Özduman and Laura R. Ment; 21. Development of motor functions in health and disease Mijna Hadders-Algra and Hans Forssberg; 22. Antenatal glucocorticoids and programming of neuroendocrine function and behavior Stephen G. Matthews and Amita Kapoor; Part VI. Consciousness: 23. On the emergence of consciousness Hugo Lagercrantz and Jean-Pierre Changeux; Index.

Editorial Reviews

Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: This is a comprehensive and updated review of current concepts about the correlations between the development of the nervous system and neurological disorders. The authors have a deep understanding of the connections between the known and the unknown aspects of neurodevelopment and disease.
Purpose: The main purpose of this book is to address neurodevelopment from multiple angles. The authors are successful in attaining their goals.
Audience: The audience is primarily neurodevelopmental scientists and neurologists who are directly involved in the care of patients with developmental disorders of the nervous system.
Features: Thirty-seven authors contribute 22 chapters in this book. The content is presented progressively to include aspects of growth factors and the development of different portions of the nervous system. There is good discussion of the newer imaging modalities and the diagnosis of disorders of the central nervous system in infants. The authors compile current evidence on the origin of epilepsy and other neurological conditions in infants and attempt to understand mechanisms for a better control of conditions that are not so well known at the present time. Moreover, there is a good correlation between basic neuroscience concepts and the development of neuronal abnormalities in infants, children, and adults. The book is well illustrated and represents a breakthrough in terms of what is known, what is unknown, and what is to be determined.
Assessment: This excellent book should be purchased by any neurological, pediatric neurological, neurosurgical, or neuroscientific libraries. It is an updated work on a very complex and yet fascinating topic.

Doody's Review Service

'… wonderful book … The editors smoothly transition from the bench to the bedside by examining techniques the clinician can use to evaluate the state of brain development and injury … At a time when there is rapidly improving understanding of brain development and neonatal brain injury, this book should be of interest to scientists and clinicians alike.' Pediatrics Adolescent Medicine

'Because of the quality and breath of materials, it remains that this book will prove relevant and useful to the broad readership of this journal. Readers may wish a copy for their own bookshelf, but they should at least request that one is stored by their institution's library.' Psychological Medicine

'The book is elegantly written and well referenced … As a comprehensive review of the most recent research results on brain development and its clinical application, this book is strongly recommended …' European Journal of Paediatric Neurology

'… a fantastically rich collection of studies and essays … comprehensive and accessible … a fascinating text and an extremely useful resource …' The Psychologist

'… unique … combines neuroscience and developmental biology with clinical aspects of fetal-neonatal brain development … the second edition adds some new chapters and information.' Doody's Notes

From the Publisher