The Handbook of Alzheimer's Disease and Other Dementias

by Andrew E. Budson (Editor), Neil W. Kowall (Editor)

Overview

The book will provide the reader with a comprehensive review of Alzheimer’s disease and other Dementias from both basic and clinical neuroscience perspectives in a single volume. There is no volume that encompasses the specific range of topics to be presented in this volume. Other volumes on the market are focused more narrowly on either basic sciences or behavioral and clinical sciences. The combination of basic molecular perspectives and cognitive neurosciences is novel.

The book opens with an introduction and overview to the major dementias and expores pathology, manifestations, and treatment and other necessary background on the diseases such as Alzheimer's, Pik's Disease, and Vascular Dementia. Section Two explores the state of the art research on specific diseas mechanism relaevant to dementia such as neuropathology and epidemiology and genetic risk factors. Seciton Three examines most recent research on major topics in cognitive and behavioral neuroscience as it relates to Dementia. The final section of the book explores the state of the art research in neuroimaging relevant to Dementia.

Product Details

ISBN-13:	9781444344097
Publisher:	Wiley
Publication date:	09/09/2011
Series:	Blackwell Handbooks of Behavioral Neuroscience , #7
Sold by:	JOHN WILEY & SONS
Format:	eBook
Pages:	656
File size:	8 MB

About the Author

Dr. Neil W. Kowall is Chief of Neurology and Director of the New England GRECC at the VA Boston Healthcare System; he is also Director of the NIH-funded Boston University Alzheimer's Disease Center, Professor of Neurology and Pathology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He has published over 170 papers in peer-reviewed journals including Science, Nature, the Journal of Neuroscience, and the Annals of Neurology.

Dr. Andrew E. Budson is the Deputy Chief of Staff and a member of the Geriatric Research Education Clinical Center (GRECC) at the VA Boston Healthcare System. He is also Associate Director for Research at the Boston University Alzheimer's Disease Center, Professor of Neurology at Boston University School of Medicine, and Lecturer in Neurology at Harvard Medical School. He was awarded the 2008 Norman Geschwind Prize in Behavioral Neurology and the 2009 Research Award in Geriatric Neurology, both from the American Academy of Neurology, and has published over 75 papers in peer-reviewed journals including the New England Journal of Medicine, Brain, and Cortex.

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Table of Contents

Contributors ix

Foreword xii

Preface xv

Part I Common Dementias 1

1 Alzheimer’s Disease 3
Alan M. Mandell and Robert C. Green

2 Vascular Dementia 92
Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon

3 Dementia with Lewy Bodies 131
Tamara G. Fong and Daniel Z. Press

4 Frontotemporal Dementia 145
Adam L. Boxer

5 Other Dementias 179
Peter Morin

Part II Pathogenesis and Disease Mechanisms 195

6 Genetic Risk Factors for Dementia 197
Paul Hollingworth and Julie Williams

7 The Neuropathology of the Dementing Disorders 235
Ann C. McKee and Brandon E. Gavett

8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262
Carmela R. Abraham

9 Other Mechanisms of Neurodegeneration 277
Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki

10 Rational Therapeutics for Alzheimer’s Disease and Other Dementias 301
Neil W. Kowall

Part III Cognitive and Behavioral Dysfunction 313

11 Memory Dysfunction in Dementia 315
Andrew E. Budson

12 Language Processing in Dementia 336
Jamie Reilly, Joshua Troche, and Murray Grossman

13 Executive Functioning 369
Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett

14 Emotion and Behavior in Alzheimer’s Disease and Other Dementias 416
Christopher I. Wright

15 Visuospatial Function in Alzheimer’s Disease and Related Disorders 457
Alice Cronin-Golomb

16 Sleep and Circadian Rhythms in Dementia 483
David G. Harper

Part IV Neuroimaging in Dementia 505

17 Glimpses of the Living Brain with Alzheimer’s Disease 507
Ronald J. Killiany

18 Functional MRI in Alzheimer’s Disease and Other Dementias 535
Maija Pihlajamäki and Reisa A. Sperling

19 Molecular Neuroimaging of the Dementias 557
Bradford C. Dickerson

20 Using EEG and MEG to Understand Brain Physiology in Alzheimer’s Disease and Related Dementias 575
Brandon A. Ally

Index 604

What People are Saying About This

From the Publisher

The Handbook of Alzheimer's Disease and Other Dementias is an impressively broad and in-depth compendium of the rapidly growing knowledge about the dementing disorders.  A notable feature of this text is the comprehensive treatment of specific cognitive and behavioral domains that characterize dementia.  The Boston University Alzheimer's Disease Center and their many collaborators in this Handbook have contributed a welcome addition to the literature.

 

-John C. Morris, Washington University School of Medicine

Editorial Reviews

It is a comprehensive volume of work and would be useful for psychologists, medical students, allied health professionals, psychiatrists and clinicians in the field of research and clinical practice.  The handbook is a credit to the author’s work and to all those who work clinically and research with this burgeoning group of individuals.”  (South West Review, 1 June 2014

“I believe this textbook will be useful to a variety of readers from different backgrounds and at different stages of training and experience and I would be very glad to have it in my library.”  (International Psychogeriatrics, 25 July 2013)

From the Publisher