Table of Contents
List of Contributors, vii
Series Preface, xi
Preface, xiii
About the Companion Website, xv
PART I Historical Introduction to the GnRH Neuron
1 The Framework Upon Which Current Research on the GnRH Neuron and its Control is Built, 3Tony M. Plant and Allan E. Herbison
PART II GnRH Neuron Development
2 Prenatal Development of GnRH Neurons, 15Yufei Shan and Susan Wray
3 Fetal/perinatal Programming Causing Sexual Dimorphism of the Kisspeptin–GnRH Neuronal Network, 43Hiroko Tsukamura, Kei-ichiro Maeda and Yoshihisa Uenoyama
4 Postnatal Development of GnRH Neuronal Function, 61Ei Terasawa
PART III GnRH Neuron Biology
5 Regulation of GnRH Gene Expression, 95Hanne M. Hoffmann and Pamela L. Mellon
6 Morphology of the Adult GnRH Neuron, 121Rebecca E. Campbell
7 The Anatomy of the GnRH Neuron Network in the Human, 149Katalin Skrapits and Erik Hrabovszky
8 Electrophysiology of Rodent GnRH Neurons, 177Richard Piet and Allan E. Herbison
9 Anatomy and Physiology of GnRH Neurons and Their Control of Pituitary Function in Fish, 203Yoshitaka Oka
PART IV Regulation of GnRH Neuron Function
10 Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function, 227Vincent Prevot and Ariane Sharif
11 Genetic Strategies Examining Kisspeptin Regulation of GnRH Neurons, 259Michael Candlish, Philipp Wartenberg and Ulrich Boehm
12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats, 289Robert L. Goodman, Satoshi Okhura, Hiroaki Okamura, Lique M. Coolen, and Michael N. Lehman
13 Generation of the GnRH Surge and LH Surge by the Positive Feedback Effect of Estrogen, 325Iain Clarke
14 Influence of Stress on the GnRH Neuronal Network, 357Pasha Grachev and Kevin T. O’Byrne
15 Metabolic Regulation of GnRH Neurons, 383Maggie C. Evans and Greg M. Anderson
16 Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel Central Mechanisms Governing Mammalian Reproduction, 411Sébastien Milesi, Paul Klosen and Valerie Simonneaux
PART V GnRH in the Clinic
17 Human Genetics of GnRH Neuron Function, 445A. Kemal Topaloglu and L. Damla Kotan
18 Modulators of GnRH Secretion and Therapeutic Applications, 469Claire L. Newton, Ross C. Anderson and Robert P. Millar
Index, 499