The Bipolar Brain: Integrating Neuroimaging and Genetics

by Stephen Strakowski (Editor)

Overview

Bipolar disorder is one of the most common, and disabling, conditions affecting humankind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this second edition of The Bipolar Brain, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. New technologies such as miRNA, cerebral blood flow, and fMRI are presented. Based upon these discussions, the authors then integrate these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.

Product Details

ISBN-13:	9780197574546
Publisher:	Oxford University Press
Publication date:	03/29/2022
Sold by:	Barnes & Noble
Format:	eBook
File size:	18 MB
Note:	This product may take a few minutes to download.

About the Author

Stephen M. Strakowski, MD, is Vice Dean for Research, and Associate Vice President, Regional Mental Health, Dell Medical School, University of Texas at Austin. He is an internationally recognized expert in the management of bipolar disorders, as a Best Doctor® and by US News and World Report® as a Top 1% Psychiatrist. His research focuses on the brain changes that occur at the onset of bipolar disorder.

Table of Contents

Preface Contributors Chapter 1: Brain Imaging Techniques and their Application to Bipolar Disorder, Caleb M. Adler Chapter 2: Structural Brain Abnormalities in Bipolar Disorder, Marcella Bellani, Niccolò Zovetti, Marsal Sanches, Koji Matsuo, Jair C. Soares, and Paolo Brambilla Chapter 3: Functional Brain Imaging in Bipolar Disorder: Activation Studies, Dylan E. Kirsch, Valeria Tretyak, Stephen M. Strakowski, and Elizabeth T.C. Lippard Chapter 4: Functional Brain Imaging in Bipolar Disorder: Connectivity And Networks, Jennifer E. Siegel- Ramsay and Jorge R.C. Almeida Chapter 5: Neurochemical and Metabolic Imaging in Bipolar Disorder, Muharrem Burak Baytunca, In Kyoon Lyoo, and Perry F. Renshaw Chapter 6: Cerebral Blood Flow in Bipolar Disorder: Past Findings and Future Directions, Megan Mio, Mikaela K. Dimick, Simina Toma, Bradley J. MacIntosh, and Benjamin I. Goldstein Chapter 7: Neuroimaging Studies of Bipolar Disorder in Youth, Manpreet K. Singh and Melissa P. DelBello Chapter 8: Neuroimaging Differences Between Bipolar and Unipolar Depression, Michele A. Bertocci, Jennifer E. Siegel- Ramsay, Jorge R.C. Almeida, Stephen M. Strakowski, and Mary L. Phillips Chapter 9: Neuroimaging in Bipolar Disorder and Schizophrenia, Grace Du and Dost Öngür Chapter 10: Genetic Techniques and Applications to Bipolar Disorder, Yuhua Zhang, Melvin G. McInnis, and Sebastian Zöllner Chapter 11: General Genetics of Bipolar Disorder, John I. Nurnberger Jr. Chapter 12: MiRNAs as Predictors of Bipolar Disorder Diagnosis and Treatment Response, Yogesh Dwivedi Chapter 13: Genetics of Bipolar Disorder and Schizophrenia, Tim B. Bigdeli and Philip D. Harvey Chapter 14: Mitochondrial Genetics and Bipolar Disorder, Christine Konradi and Tadafumi Kato Chapter 15: Integration and Consolidation: A Neurophysiological Model of Bipolar Disorder, Stephen M. Strakowski and Gin S. Malhi Index

Editorial Reviews

Reviewer: Michael Easton, MD (Rush University Medical Center)
Description: This second edition is an update of the 2012 publication. It presents a comprehensive review of the tools used to study bipolar disorder, primarily imaging and genomics, in order to help develop an integrative model of this illness.
Purpose: There have been significant changes in the field since the first edition. The purpose of the second edition was to have experts in neuroimaging and genetics provide up-to-date findings regarding structural, functional, and chemical brain changes involved in bipolar disorder, as well as the genetics that may underly them. This book has added the most current updated information to expanded and new chapters to further develop a neurophysiological model of bipolar disorder.
Audience: This book is written for physicians and researchers in this area to serve as a resource to help readers come to new understandings of bipolar disorder, leading to new therapies and novel strategies to treat individuals with this condition and ideally develop preventive strategies for those at risk.
Features: This book consists of 10 chapters, the first nine of which are devoted to neuroimaging. The first chapter covers topics of imaging techniques and their application in bipolar disorder. Chapters 2-6 cover structural brain abnormalities and functional imaging looking at issues around connectivity and networks, neurochemical and metabolic imaging, as well as cerebral blood flow. Chapters 7-9 look at issues in youth, as well as comparative studies with unipolar depression and schizophrenia. Chapters 10-14 look at general genetics, the role of microRNA as predictors in diagnosis and treatment, mitochondrial genetics, and the overlap between bipolar disorder and schizophrenia. The final chapter looks at developing a neurophysiological model of bipolar disorder.
Assessment: This book is an up-to-date, comprehensive review of structural and functional neuroimaging findings as well as the current understanding of genetics and that which affects its expression. The attempt is to integrate the two with the aim of developing a more comprehensive neurophysiological understanding of this illness. Overall, this book is worthwhile for those involved in the treatment and understanding of this debilitating disorder.

Doody's Review Service

"The Bipolar Brain is an excellent, comprehensive, thoughtful, and cutting edge overview of what we know about the intersecting worlds of genetic and neuroimaging research in bipolar illness. It is also a first-rate gateway into the future." — Kay Redfield Jamison, PhD, The Dalio Family Professor in Mood Disorders and Professor of Psychiatry, Johns Hopkins School of Medicine

"The Bipolar Brain is an outstanding compendium and synthesis summarizing the substantial advances to date in understanding the genetics, brain structures and function involved in the clinical manifestations of bipolar disorder. Highly readable and clinically relevant, with contributors who have led the fields of clinical neuroscience in bipolar disorder, this volume in itself advances the field." — Paul E. Keck, Jr., MD, President-CEO, Lindner Center of Hope

"Strakowski and a stellar group of colleagues have produced a volume much awaited by the field. They provide us with an integrated neurophysiological model of bipolar disorder by focusing on neuroimaging and genetic findings- no doubt the most robust biomarkers on the pathophysiology of this devastating condition. This volume achieves its goal of providing us with a neurophysiological paradigm of bipolar disorder - A volume that will be of great value not only to investigators in the field but also to clinicians treating patients with bipolar disorder who wish to better understand its pathophysiology. This book gives me hope that with a better understanding of the condition, our patients will benefit from better treatments. The goal of developing treatments tailored to neuroimaging and genetic finding may not be that far away after all." — Mauricio Tohen MD, DrPH, MBA, President, International Society for Bipolar Disorders

"The Bipolar Brain provides an abundance of readily accessible information on ways that brain imaging methods can aid in understanding the psychopathology, illness course, and interrelationships between brain structure and functions and other fundamental areas of investigation about bipolar disorders. For persons interested in incorporating brain imaging methodologies, an excellent overview addresses the principles, particular strengths and limitations of the several primary techniques available in the field of imaging methodologies. Much of the book focuses on multi-system studies. In particular a section on interrelationships between mitochondrial functions and impact on brain structure and function, as well as the unique genetic underpinnings of mitochondrial systems, is worth reading even by scientists working solely outside the field of brain imaging studies." —Charles L. Bowden, MD, Professor of Clinical Psychiatry, The University of Texas Health Science Center at San Antonio

"This excellent book covers the fast growing research into the genetics and neuroimaging of bipolar disorder and presents a new neurophysiological model of the disorder. Any informed psychiatrist would want to read this outstanding book." — Michael Joel Schrift, D.O., M.A., University of Illinois at Chicago College of Medicine, Doody's

"This is an extremely up-to-date and well-written compilation of chapters by leaders in the field of the interface between neuroimaging and genetics in bipolar disorder...This book is a fine expression of the momentum spearheaded by the National Institute of Mental Health toward a "circuits" approach to psychiatric disorder and in that sense is a good introduction for anyone interested in psychiatric research..." — R. H. Belmaker, American Journal of Psychiatry

"Understanding the structural and functional abnormalities within bipolar disease is an evolving process. This superb review will allow the reader to ascertain what is known up to 2012 and better integrate new findings that will be published. It is reasonably priced, beautifully produced, and should be in all medical libraries, but also in libraries of any psychiatrist who works with many bipolar patients." —Thomas N. WIse, M.D., Johns Hopkins University School of Medicine

"Understanding the structural and functional abnormalities within bipolar disease is an evolving process. This superb review will allow the reader to ascertain what is known up to 2012 and better integrate new findings that will be published. It is reasonably priced and beautifully produced and should be in all medical libraries, but also in the library of any psychiatrist who works with many bipolar patients. It is quite a bargain and is certainly worthy of future editions." —Journal of Clinical Psychiatry

From the Publisher