Testosterone: Action - Deficiency - Substitution / Edition 2

by Eberhard Nieschlag, Hermann M. Behre

Overview

The first edition of "Testosterone: Action, Deficiency, Substitu­ tion" was published in 1990. Since then our understanding of the hormone that turns males into men has tremendously increased. Therefore, the editors felt that a second extended edition of the book is warranted in order to summarize established and recent findings in the field and to present the reader with an up-to-date is reflected by the textbook. The increased mass of knowledge growth of the volume from 14 to 20 chapters. In the updated edition the biochemistry and metabolism of androgens have been complemented by extensive information on the molecular biology of the androgen receptor and its disorders. The key role of testosterone in spermatogenesis is now better de­ fined. We have a more complete understanding of the psychotro­ pic effects of testosterone and know so much about the different target organs and functions that individual chapters deal with testosterone and the prostate, lipids and the cardiovascular system, hair, bones and muscles. The general chapter on pharmacol­ ogy and clinical uses of testosterone, in particular in male hypo­ gonadism, is extended by pharmacokinetic studies on testoster­ one preparations and individual substitution modalities using testosterone esters as well as implants and advanced trans dermal applications. The physiologic basis and possible clinical applications of testosterone in non-gonadal diseases, in male senes­ cence, in hormonal male contraception and in transsexuals are discussed. The last chapter describes the role of "investigative" steroid biochemistry applied to tracking anabolic steroid abuse.

Product Details

ISBN-13:	9783642721878
Publisher:	Springer Berlin Heidelberg
Publication date:	11/23/2011
Edition description:	2nd ed. 1998. Softcover reprint of the original 2nd ed. 1998
Pages:	598
Product dimensions:	6.10(w) x 9.25(h) x 0.05(d)

Table of Contents

Testosterone - Overview of Biosynthesis, Transport, Metabolism and Non-genomic Actions of Testosterone. The Androgen Receptor - Physiology and Pathophysiology. Behavioural Correlates of Testosterone. The Role of Testosterone in Spermatogenesis. Androgens and Hair. Androgens and Bone Metabolism. Androgens and Muscles. Androgens - Cardiovascular Risk Factors and Atherosclerosis. Androgens and the Prostate. Pharmacology and Clinical Uses of Testosterone. Comparative Pharmacokinetics of Testosterone Esters. Clinical Pharmacology of Testosterone Pellet Implants. Long-term Experience with Testosterone Replacement Through Scrotal Skin. A Permeation-enhanced Non-scrotal Testosterone Transdermal System for the Treatment of Male Hypogonadism. Percutanous Dihydrotestosterone Treatment. Androgens in Male Senescence. Androgen Therapy in Non-gonadal Disease. Testosterone in Male Contraception. Androgen Treatment of Female-to-male Transsexuals. Abuse of Androgens and Detection of Illegal Use.

Editorial Reviews

Reviewer: Jennifer M. Cunningham, MD (University of Chicago Medical Center)
Description: This is a broad overview of androgen physiology. The first edition was published in 1990, and this new edition has a broader scope and is more detailed, thanks to the advancements in our understanding of testosterone physiology since that time.
Purpose: The purpose is to teach androgen biochemistry, metabolism, physiology, and clinical utility and to present the most up-to-date information available.
Audience: This book is an excellent reference for physicians, particularly endocrinologists, pharmacologists, and anyone interested in endocrine physiology.
Features: Each chapter is written following an outline format, so that it may be read as a well-constructed whole or portions may be used for reference. The tables and figures are simple and easily understood, and the references are extremely current. The first chapters of the book are devoted to testosterone and androgen receptor physiology and pathophysiology. From there the chapters progress into comprehensive discussions of testosterone's effects on various organ systems. The second half of the book is then devoted to the pharmacology and potential therapeutic uses of this hormone.
Assessment: Because this text is comprehensive, readable, and current, it would be an excellent addition to any endocrinologist's library.

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