Systems Biology: Applications and Perspectives / Edition 1

by P. Bringmann, E. Butcher, G. Parry, B. Weiss

Overview

Systems biology has emerged as a highly interdisciplinary field that has created broad enthusiasm in the scientific community. Systems biology is in vogue because of its potential to revolutionize not only biology but also medicine. Developments are anticipated that will change how we think about disease and how we approach therapeutic intervention. Perhaps the boldest vision of this future is presented by Dr. Leroy Hood, President of the Institute for Systems Biology in Seattle. He has been a protagonist and the main driving force of the underlying concept. - cording to Dr. Hood, systems biology will make possible a new era of medical care comprising predictive, preventive, personalized and part- ipatory (P4) medicine. While this vision appears futuristic, it has enticed both academic scientific communities and pharmaceutical industry R&D organizations. Systems biology ultimately attempts to understand biological systems at the molecular level. Examples of such systems are subcellular regulatory circuits with all their components, cells, organs, as well as - tire organisms. Over the past decade, technologies have been developed that enable systems-level interrogations, e.g., gene expression profiling, proteomics, and metabonomics, to name a few. Scientists have used such platforms to accumulate a tremendous amount of data. Although we have learned a great deal by collecting such detailed information, it seems our understanding has not similarly increased.

Product Details

ISBN-13:	9783642421587
Publisher:	Springer Berlin Heidelberg
Publication date:	11/27/2014
Series:	Ernst Schering Foundation Symposium Proceedings , #61
Edition description:	2007
Pages:	177
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

RNAi Applications in Target Validation.- Does the Serum Peptidome Reveal Hemostatic Dysregulation?.- Systems Biology: New Paradigms for Cell Biology and Drug Design.- The Theory of Biological Robustness and Its Implication in Cancer.- Network Genomics.- A Plea for More Theory in Molecular Biology.- Applying a Causal Framework to System Modeling.- Can Cell Systems Biology Rescue Drug Discovery?.