Systems Biology / Edition 1

by Mohamed Al-Rubeai, Martin Fussenegger

Overview

A comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering, this volume presents an overall picture of the current topics central to structural and functional genomics, proteomics, metabolomics and bioinformatics, including such hot topics as RNAi, metabolic engineering and unfolded protein response. It includes reviews of the cellular response of environmental modulation such as low temperature and osmolarity, critical assessments of the applications of metabolomics and fluxomics approaches, examination of the utility of modulation of key genes and a presentation of a theory of chemical organisation which provides a new view of the system's structure. The clearly written chapters by experts in the field describe methods applicable to investigating the unique facets of cell culture. The book should be of interest to all those working in cell culture development and drug discovery in pharmaceutical and biotechnology companies as well as in academic institutions. It provides an invaluable resource for students and researchers in biotechnology, cell culture, genomics and bioinformatics.

Product Details

ISBN-13:	9789048173228
Publisher:	Springer Netherlands
Publication date:	11/19/2010
Series:	Cell Engineering , #5
Edition description:	Softcover reprint of hardcover 1st ed. 2007
Pages:	424
Product dimensions:	6.30(w) x 9.45(h) x 0.04(d)

Table of Contents

Structural Genomics.- RNA Interference in Haematopoietic and Leukaemic Cells.- Genomics and Proteomics of Chinese Hamster Ovary (CHO) Cells.- The Unfolded Protein Response.- Engineering of Cell Proliferation Via Myc Modulation.- The Molecular Response(s) During Cellular Adaptation to, and Recovery from, Sub-Physiological Temperatures.- Molecular Response to Osmotic Shock.- Metabolomics.- Metabolic Flux Analysis of Mammalian Cells.- Metabolic Engineering.- Chemical Organisation Theory.- Prokaryotic Systems Biology.

Editorial Reviews

Reviewer: Bruce A. Fenderson, PhD (Thomas Jefferson University)
Description: The authors believe that it will be possible in the future to engineer cells to achieve a desired cellular phenotype based on detailed knowledge of metabolic and signaling networks. This overview of current research in the field of systems biology (bioengineering, theoretical biology, and proteomics) covers topics ranging from RNA interference in hematopoietic and leukemic cells to engineering of cell proliferation via myc modulation. The primary focus is on cell biology and biochemistry.
Purpose: The purpose is to illustrate various approaches to cell engineering and provide guidance to those interested in systems biology research. The editors and authors hope to stimulate research in basic and applied cell biology (translational medicine). The authors are experts and leaders in this emerging field.
Audience: This book is written for basic science and clinical researchers interested in biotechnology and cellular engineering. Biomedical scientists involved in genomics/proteomics research and drug discovery will also appreciate the wealth of information and interesting new concepts presented.
Features: The authors summarize a particular aspect of systems biology and illustrate methods and results with data from their laboratories. The chapters are well written and the topics are interesting. The tables and black-and-white illustrations are helpful. Each chapter includes an abstract, list of keywords, helpful introduction, and references.
Assessment: This is a helpful guide for those interested in systems biology, cell technology, and the future of bioengineering. A general introduction by the editors would have helped to frame the scope of systems biology. Some of the chapters include too much detail and too many references. The extensive use of abbreviations makes it difficult for non-experts to read with understanding, although the book is intended both for advanced students and experts in theoretical systems biology. What's most important is that it presents a new way of thinking about regulatory networks in biological systems. The authors illustrate their work nicely and provide general readers with a vision of future developments expected in cellular engineering.

Doody's Review Service

From the reviews:

"This book is written for basic science and clinical researchers … . Biomedical scientists involved in genomics/proteomics research and drug discovery will also appreciate the wealth of information and interesting new concepts presented. … The chapters are well written and the topics are interesting. … the book is intended both for advanced students and experts in theoretical systems biology. … The authors illustrate their work nicely and provide general readers with a vision of future developments expected in cellular engineering." (Bruce A. Fenderson, Doody’s Review Service, August, 2008)

From the Publisher