Synthetic Peptides: A User's Guide / Edition 2

by Gregory Grant

Overview

The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are often unfamiliar with not only the synthetic chemistry but also with important and useful aspects of design, analysis, handling, and applications. This volume is the second edition of a volume that was first published 10 years ago. It is written by experts in the field who provide detailed descriptions as well as practical advice for producing and using synthetic peptides. The various chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product, and the modern applications of synthetic peptides. This includes the basic principles of peptide structure, analysis and chain assembly as well as the latest in selective disulfide bond formation, new strategies for the production of large peptides, and sequencing peptides by mass spectrometry. This book was designed with the intent of providing useful information both for the novices to the field as well as more seasoned practitioners. Its contents will help prevent problems commonly encountered and allow scientists to optimize their use of synthetic peptides.

Product Details

ISBN-13:	9780195132618
Publisher:	Oxford University Press
Publication date:	04/04/2002
Series:	Advances in Molecular Biology
Edition description:	REV
Pages:	400
Product dimensions:	9.30(w) x 6.10(h) x 1.00(d)

About the Author

Washington University School of Medicine, St.Louis

Table of Contents

Contributors1. Synthetic Peptides: Beginning the Twenty-first Century, Gregory A. Grant2. Peptide Design Considerations, Michael L. Moore & Gregory A. Grant3. Principles and Practice of Solid-Phase Peptide Synthesis, Gregg B. Fields, Janelle L. Lauer-Fields, Rong-qiang Liu, & George Barany4. Evaluation of the Synthetic Product, Gregory A. Grant5. Applications of Synthetic Peptides, Victor J. Hruby & Terry O. MatsunagaIndex

Editorial Reviews

"[A] valuable resource for anyone involved in peptide research. This book would also serve as a good reference book for a course devoted to peptide chemistry."—Polymer News

From the Publisher

Detailed descriptions of processes involved in producing and using synthetic peptides are provided here. Information is given on peptide design considerations, synthetic chemistry, evaluation of the synthetic product, and modern applications of synthetic peptides. Basic principles of peptide structure, analysis, and chain assembly are reviewed, and innovations such as sequencing peptides by mass spectrometry are discussed. This second edition reflects changes in the field over the past 10 years. Grant teaches biochemistry in medicine and molecular biology and pharmacology at Washington University School of Medicine. Annotation c. Book News, Inc., Portland, OR (booknews.com)