Surface Analysis and Techniques in Biology

by Vincent S. Smentkowski (Editor)

Overview

This book summarizes the main surface analysis techniques that are being used to study biological specimens/systems. The compilation of chapters in this book highlight the benefits that surface analysis provides.

The outer layer of bulk solid or liquid samples is referred to as the surface of the sample/material. At the surface, the composition, microstructure, phase, chemical bonding, electronic states, and/or texture is often different than that of the bulk material. The outer surface is where many material interactions/reactions take place. This is especially true biomaterials which may be fabricated into bio-devices and in turn implanted into tissues and organs. Surfaces of biomaterials (synthetic or modified natural materials) are of critical importance since the surface is typically the only part of the biomaterial/bio-device that comes in contact with the biological system.

Analytical techniques are required to characterize the surface of biomaterials and quantify their impact in real-world biological systems. Surface analysis of biological materials started in the 1960’s and the number of researchers working in this area have increased very rapidly since then, a number of advances have been made to standard surface analytical instrumentation, and a number of new instruments have been introduced.

Product Details

ISBN-13:	9783319013596
Publisher:	Springer International Publishing
Publication date:	03/19/2014
Edition description:	2014
Pages:	326
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

About the Author

Vincent S. Smentkowski is a Senior Scientist in the Nanostructures and Surfaces Laboratory at General Electric Global Research (GEGR) where he performs surface analysis to support research programs at GEGR, GE businesses, and strategic partners. Currently, his research is focused on the applications of ToF-SIMS analysis, emphasizing how multivariate statistical analysis tools facilitate data reduction. Vin holds 6 U.S. patents, more than 85 publications in referred journals, greater than 100 GEGR internal manuscripts, has co-authored 3 book chapters, and has presented numerous contributed and invited talks. Vin is a Fellow of the American Vacuum Society.  

Table of Contents

Introduction.- Applications of XPS in Biology and Biointerface Analysis.- Biomolecular Analysis by Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS).- Cluster Secondary Ion Mass Spectrometry.- Biological Tissue Imaging at Different Levels: MALDI and SIMS Imaging Combined.- Molecular Structure and Identification Through G-SIMS and SMILES.- Imaging with the Helium Ion Microscope.- Sum Frequency Generation Vibrational Spectroscopy: A Sensitive Technique for the Study of Biological Molecules at Interfaces.- Near-Field Scanning Optical Microscopy: A New Tool for Exploring Biological Structure and Function in Biology.- Atomic Force Microscopy: Applications in the Field of Biology.- Multi-technique Characterization of DNA-modified Surfaces for Biosensing and Diagnostic Applications.