Studies in Natural Products Chemistry: Stereoselective Synthesis (Part K)

by Atta-ur Rahman

Overview

In Volume 18 of this well-established series, Professor Atta-ur-Rahman again brings together the work of several of the world's leading authorities in organic chemistry. Their contributions demonstrate the rapid, ongoing development of this field by illustrating many of the latest advances in synthetic methods, total synthesis, structure determination, biosynthetic pathways, and biological activity.The opening chapter presents an overview of strategies for the synthesis of several classes of natural products with an emphasis on complex polycyclic systems. Subsequent chapters discuss the synthesis of specific classes of compounds, including morphine, polyketides, acetogenins, nonactic acid derivatives, complex spirocyclic ethers, ä-lactam and pyridone derivatives, inositol phosphates, sphingolipids, brassinosteroids, Hernandia lignans, and dimeric steroidal pyrazine alkaloids. Finally, the ever stronger links between chemistry and biology are reinforced by chapters on the origin and function of secondary metabolites, bioactive conformations of gastrin hormones, and immunochemistry.

Product Details

ISBN-13:	9780080541778
Publisher:	Elsevier Science
Publication date:	05/01/1996
Series:	ISSN , #18
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1116
File size:	53 MB
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About the Author

Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.

Table of Contents

Foreword. Total synthesis of polycarbocyclic marine terpenoids (J.D. Martin). Stereoselective total syntheses of spongian-type diterpenes and scalarane-type sesterterpenes of metabolites from marine sponge organisms (T. Nakano). Allenic and acetylenic carotenoids (S. Liaaen-Jensen). Synthetic studies on gibberellins and antheridiogens (L.N. Mander). Recent advances in the chemistry of secondary metabolites isolated from Fusarium species (M.E. Savard et al.) Amphotericin B: synthetic studies (O.S. Chizhov). Development of dithioacetal S-oxides and S,S-dioxides as synthetic reagents (K. Ogura). Sugar analogs containing carbon-phosphorus bonds (H. Yamamoto, T. Hanaya). Syntheses and reactions of sugar-peptide structures related to cell-wall peptidoglycan from bacteria (D. Keglević). Chemical defense in ants (J.C. Braekman, D. Daloze). Some aspects of heterocyclic chemistry related to isoquinoline-derived alkaloids (J.B. Bremner). Alkaloids of Strychnos dinklagei: structure and chemistry (S. Michel et al.). Chiral synthesis of natural products as semiochemicals and bioregulators (T. Kitahara). Subject Index.