Structured Biological Modelling: A New Approach to Biophysical Cell Biology / Edition 1

by Michael Kraus, Bernhard Wolf

Overview

Structured Biological Modelling presents a straightforward introduction for computer-aided analysis, mathematical modelling, and simulation of cell biological systems. This unique guide brings together the physiological, structural, molecular biological, and theoretical aspects of the signal transduction network that regulates growth and proliferation in normal and tumor cells. It provides comprehensive survey of functional and theoretical features of intracellular signal processing and introduces the concept of cellular self-organization. Exemplified by oscillatory calcium waves, strategies for the design of computer experiments are presented that can assist or even substitute for time-consuming biological experiments. The presented minimal model for proliferation-associated signal transduction clearly shows the alterations of the cellular signal network involved in neoplastic growth. This book will be useful to cell and molecular biologists, oncologists, physiologists, theoretical biologists, computer scientists, and all other researchers and students studying functional aspects of cellular signaling.

Product Details

ISBN-13:	9780849347726
Publisher:	Taylor & Francis
Publication date:	07/31/1995
Edition description:	New Edition
Pages:	238
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Michael Kraus, Bernhard Wolf

Table of Contents

PrefaceHolistic Approaches for Data Acquisition in Cell Biology-The Basis for SBMHolistic Versus Molecular Biological Methods: A Fundamental Complementarity Between Experimental StrategiesSelected Minimal-Invasive Techniques for Holistic Data Acquisition in Cell BiologyAnalytical Light MicroscopyAnalytical Electron MicroscopyFurther Analytical Techniques with Relevance for SBMImage AnalysisCellular Biosensors: Powerful Electrical Devices for the Detection of Biomolecular SignalsStructured Biological Modelling (SBM)-Technique and ApplicationsThe SBM CyclePreliminary Remarks about the Modelling of Biological SystemsStructured AnalysisMathematical Specification of the DFD ModelStochastic Simulation of the Mathematical ModelSBM Applied to Intracellular Ca2+ OscillationsThe Experimental BasisCritical Discussion of Minimal Models for Intracellular Ca2+ OscillationsMicroscopic View of Ca2+ Oscillators Represented by Stochastic Models: The Stochastic Two-Pool OscillatorA SBM Model for Oscillatory Intracellular Ca2+ Waves in Nonexcitable CellsMinimal Model of the Cellular Signal Transduction NetworkThe Cell CycleModules of the Intracellular Signal NetworkStructured Analysis of Proliferation-Associated Cell SignalingThe Minimal Model of the Mitogenic Signal Transduction Network: Discussion and OutlookEmergence of Self-Organization in Tumor BiologyBrief Phenomenology of Self-Organized Cellular StructuresPhysical PreliminariesPhase Transitions in Cell Cycle and Neoplastic GrowthNeoplastic Growth as a Process of Cellular Self-Organization?The Hierarchy of Biological Systems: Microenvironmental Hydrogen Ion Concentration as Central Order Parameter for Invasive Tumor GrowthSummary and OutlookReferences

Editorial Reviews

Presents a synthesis of experimental biological techniques and concepts of systems analysis and modeling, examining the regulation of biological systems, especially cellular signalling networks, from a systems-oriented viewpoint, and showing how data can be converted into a consistent computer model that comprises functional properties of the system. Part I discusses experimental techniques, emphasizing various types of microscopy and image analysis. Part II details the development of a computer model from experimental data. Includes b&w and a few color images. Of interest to cell and molecular biologists, oncologists, physiologists, theoretical biologists, and computer scientists, and advanced students in these fields. Annotation c. by Book News, Inc., Portland, Or.

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