Structural Biology and Functional Genomics / Edition 1

by E. Morton Bradbury, Sïndor Pongor

Overview

Biomedical research will be revolutionised by the current efforts to sequence the human genome and the genomes of model organisms. Of the newly sequenced genes, 50% code for proteins of unknown functions, while as little as 5% of sequences in mammalian genomes code for proteins. New, genome-wide approaches are needed to draw together the knowledge that is emerging simultaneously in a number of fields of genome research.
This volume is a high-level survey of the newly emerging concepts of structural biology and functional genomics for biologists, biochemists and medical researchers interested in genome research. Topics included are chromosome and chromatin organisation, novel DNA and RNA structures, DNA flexibility, supercoiling, prediction of protein functions, strategies for large scale structural analysis, and computer modelling.

Product Details

ISBN-13:	9780792357827
Publisher:	Springer Netherlands
Publication date:	08/31/1999
Series:	NATO Science Partnership Subseries: 3 , #71
Edition description:	Softcover reprint of the original 1st ed. 1999
Pages:	313
Product dimensions:	6.30(w) x 9.45(h) x (d)

Table of Contents

The Skeletal Function of Non-Genic Nuclear Dna: New Evidence From Ancient Cell Chimaeras.- DNA Repeats in the Human Genome.- Left-Handed Z-Dna: Structure and Function.- Superhelical Dna Studied by Solution Scattering and Computer Models.- Micro-Mechanical Measurement of the Torsional Modulus of Dna.- Sequence-Dependent Modelling of Local Dna Bending Phenomena: Curvature Prediction and Vibrational Analysis.- Modelling Dna Stretching for Physics and Biology.- Single-Chain 434 Repressors with Altered DNA-Binding Specificities: Isolation of Mutant Single-Chain Repressors by Phenotypic Screening of Combinatorial Mutant Libraries.- Fast Combinatorial Cartography by Fish on Combed Genomic DNA.- Rna Folding and Catalysis.- Histone-Dna Contacts in Structure/Function Relationships of Nucleosomes as Revealed by Crosslinking.- The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression.- Chromatin Control of HIV-1 Gene Expression.- Mechanisms of Separation of the Complementary Strands of DNA During Replication.- Exploring Structure Space: A Protein Structure Initiative.- The Protein Data Bank: Bridging the Gap Between the Sequence and 3d Structure World.- Functional Genomics and Enzyme Evolution: Homologous and Analogous Enzymes Encoded in Microbial Genomes.- The Beamlines of Elettra and Their Application to Structural Biology.- Participants List.

Editorial Reviews

Deciphering the roles of "junk" DNA and the 50 percent of proteins of unknown function that have emerged from the already completed genome sequences of microbes is in the purview of the new field of functional genomics. The 18 articles representing the May 1998 NATO workshop held at its co-sponsor's home, the International Centre for Genetic Engineering and Biotechnology in Trieste, Italy, provide a snapshot of this juncture in genome-wide approaches to understanding biological functions. Sample titles include: DNA repeats in the human genome, Modeling DNA stretching for physics and biology, Chromatin control of HIV-1 gene expression, and Exploring structure space: a protein structure initiative. Some of the graphics are in color. Includes a list of the participants from 17 countries. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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