Strategies and Tactics in Organic Synthesis

by Michael Harmata (Editor)

Overview

Strategies and Tactics in Organic Synthesis, Volume 13, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project.

Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world.

• Provides insight and offers new perspective to problem-solving
• Presents state-of-the-art developments in organic synthesis
• Written by leading experts in the field
• Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

Product Details

ISBN-13:	9780128222126
Publisher:	Elsevier Science
Publication date:	11/15/2021
Series:	Strategies and Tactics in Organic Synthesis , #15
Pages:	444
Product dimensions:	6.00(w) x 9.00(h) x 0.90(d)

About the Author

Professor Michael Harmata graduated from the University of Illinois-Chicago with honors and highest distinction in chemistry.

In 1980, he began graduate studies in chemistry at the University of Illinois-Champaign/Urbana where he was awarded a University Teaching Fellowship. He worked with Professor Scott E. Denmark on the invention of the carbanion-accelerated Claisen rearrangement. In his second year of study, he was awarded an Eastman Kodak Research Fellowship.

Upon graduation in 1985, he was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A. Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore.

In 1986, Prof. Harmata began his independent career at the University of Missouri-Columbia. He became an Associate Professor in 1992 and a full professor in 1998. In 2000, he was named the Norman Rabjohn Distinguished Professor of Chemistry in recognition of his achievements in research and teaching. In 1998, he received a research fellowship from the Alexander von Humboldt Foundation and stayed for a year at the University of Göttingen where he was affiliated with the groups of Professors Reinhard Brückner and Lutz. F. Tietze. In 2000, he served as chair of the Gordon conference on Organic Reactions and Processes. In 2010, he was named the first Justus Liebig Professor of Chemistry at the Justus Liebig Üniversität in Giessen, Germany. In 2011, he was a JSPS fellow. He has been a visiting professor in Giessen and Strasbourg and has delivered over 180 invited lectures in the United States and Europe. He is a member of the American Chemical Society, Gesellschaft Deutscher Chemiker, International Society of Heterocyclic Chemistry, and the Alexander von Humboldt Association of America.

Table of Contents

1. Amaryllidaceae isocarbostyril alkaloids
2. Enzymatic dihydroxylation of aromatic compounds: Nature’s unique reaction and its impact on the synthesis of natural products
3. Intermolecular oxidopyrylium [5+2] cycloaddition chemistry and its application toward the synthesis and study of highly oxygenated troponoids
4. Aryne-mediated construction of fluorene skeletons and its applications to total synthesis of selaginpulvilins
5. Cycloisomerizations across three states: the total synthesis of gelsenicine
6. Tetrapetalones ruminations, trials and tribulations
7. The synthesis of herqulines B and C
8. First total synthesis of the dimeric naphthoquinonopyranolactone natural product (-)-crisamicin A. how procrastination may be of help in binaphthyl synthesis
9. Strategies and discoveries leading to the synthesis of trichoaurantianolide natural products
10. 4-exo-dig cyclocarbopalladation, discovery and application in the synthesis of complex polycyclic molecules

What People are Saying About This

From the Publisher

Covers the art and science of organic synthesis, looking at state-of-the-art advances in the past year

Editorial Reviews

"This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike."
J. AM. CHEM. SOC, Vol. 128, no. 10, 2006

From the Publisher