Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

by Hartmut Geiger (Editor), Heinrich Jasper (Editor), Maria Carolina Florian (Editor)

Overview

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stemcells, aging mechanisms or age-related diseases.

Product Details

ISBN-13:	9783709112311
Publisher:	Springer Vienna
Publication date:	07/07/2015
Edition description:	1st ed. 2015
Pages:	354
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Hartmut Geiger studied chemistry and biochemistry at the Universities of Karlsruhe and Witten/Herdecke in Germany. He received his PhD from the Max-Planck-Institute for Immunobiology in Freiburg, Germany in 1999. From 1999 to 2002 he was scientific research fellow at the University of Kentucky, USA with expertise in stem cells, genetics and aging. From 2002 to 2008 he was Assistant Professor at the Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, USA. Since 2008 he has been Associate Professor at the University of Cincinnati, USA and Professor at the University of Ulm, Division of Dermatology and Allergic Diseases, Germany. His main research interest lies in the molecular biology of aging.

Table of Contents

Introduction.- Stem cells, aging and longevity (overview).- General mechanisms of stem cell aging (overview).- Mechanisms of Stem Cell Aging in Model Organisms.- Yeast: Chronological aging.- Divisional aging.- Primarily germline.- stem cell aging.- Drosophila: Male germ line.- Female germ line.- Somatic stem cells (stress and regulation of hematopoietic precursors, intestinal stem cell aging and regulation). Zebrafish.- Mechanisms of Stem Cell Aging in Mammalian Tissues.-Hematopoietic (Mouse/Human).- Skin (Mouse/Human).- Intestine (Mouse/Human).- Muscle (Mouse/Human).- Neuronal Tissues (Mouse/Human).- Diseases of Aging and Stem Cells.- Chronic Myeloid Leukemia and Aging of Hematopoietic Stem Cells (Mouse/Human).- Wound Healing Repair and Aging of Skin Stem Cells (Mouse/Human).- Stem Cell Rejuvenation Muscle.- Hematopoietic.- Neuronal.

Editorial Reviews

Reviewer: Michele Fornaro, PhD (Midwestern University)
Description: This book discusses the impact of aging on the many stem cell populations, the pathologies associated with the decline of stem cell functions, and the use of stem cells to attenuate stem cell aging.
Purpose: This collection of article-like chapters addresses the mechanisms of stem cell aging in a variety of model systems including mammalian tissues. Moreover, it introduces new promising approaches to delay aging or attenuate its effects on stem cells. The purpose is to provide a reference for researchers working in the field of healthy aging.
Audience: The audience is clinicians and all scientists working in the field of aging, stem cells, and regenerative medicine.
Features: Chapters are grouped into four parts. Part I is an overview of stem cell aging. Part II introduces mechanisms of stem cell aging from a variety of models, from single cells to drosophila. Stem cell aging in mammalian tissues is discussed in part III. The final part discusses the use of stem cells to repair damaged tissue and counteract the effects of aging. Chapters are organized as scientific papers featuring an abstract, an introduction, a discussion, and conclusions. Each chapter ends with a list of references. Graphics are used where needed.
Assessment: Overall, this book offers insights into stem cell functions and summarizes the current state of knowledge of the cellular and molecular mechanisms of stem cell aging in many models, with a particular focus on mammalian cell types. It also highlights promising approaches to counteract aging and attenuate the pathological consequences associate with stem cell aging.

Doody's Review Service

This book discusses the impact of aging on the many stem cell populations, the pathologies associated with the decline of stem cell functions, and the use of stem cells to attenuate stem cell aging. … The purpose is to provide a reference for researchers working in the field of healthy aging. The audience is clinicians and all scientists working in the field of aging, stem cells, and regenerative medicine.” (Michele Fornaro, Doody's Book Reviews, October, 2015)

From the Publisher