Statistical Methods in Drug Combination Studies

by Wei Zhao (Editor), Harry Yang (Editor)

Overview

The growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. Howeve

Product Details

ISBN-13:	9781040074954
Publisher:	CRC Press
Publication date:	12/19/2014
Series:	Chapman & Hall/CRC Biostatistics Series
Sold by:	Barnes & Noble
Format:	eBook
Pages:	240
File size:	2 MB

Table of Contents

Drug Combination: Much Promise and Many Hurdles. Drug Combination Synergy. Drug Combination Design Strategies. Confidence Interval for Interaction Index. Two-Stage Response Surface Approaches to Modeling Drug Interaction. A Bayesian Industry Approach to Phase I Combination Trials in Oncology. Statistical Methodology for Evaluating Combination Therapy in Clinical Trials. Challenges and Opportunities in Analysis of Drug Combination Clinical Trial Data. Software and Tools to Analyze Drug Combination Data.

Editorial Reviews

"This book is a welcome addition to the literature and fills a needed niche since last book written on drug synergism was over 15 years ago . . . Overall, this book serves as a good reference for both researchers in the field of statistics and drug combination development."
~ Jessica L. Jaynes, California State University, Fullerton

"Investigating drug combinations is a steadily growing area in preclinical and clinical research.As usual, specific statistical methodology is needed to handle these kinds of trials. . . .the book is generallywell structured and the majority of sections actually builds up on and refers to each other. This book provides a good overview on and a good introduction to the topic of statistical methods for drug combination studies, especially regarding the preclinical part."
~ Tim Holland-Letz, German Cancer Research Center Heidelberg

"This book is a welcome addition to the literature and fills a needed niche since last book written on drug synergism was over 15 years ago . . . each chapter presents a different technique for solving common challenges in the development of drug combinations. . . Overall, this book serves as a good reference for both researchers in the field of statistics and drug combination development."
~ Jessica L. Jaynes, California State University, Fullerton

"Investigating drug combinations is a steadily growing area in preclinical and clinical research.As usual, specific statistical methodology is needed to handle these kinds of trials. . . .the book is generallywell structured and the majority of sections actually builds up on and refers to each other. This book provides a good overview on and a good introduction to the topic of statistical methods for drug combination studies, especially regarding the preclinical part."
~ Tim Holland-Letz, German Cancer Research Center Heidelberg

From the Publisher