Table of Contents
Preface v
Chapter 1 Stimuli-Sensitive Nanopreparations: Overview Aditi Jhaveri Vitaly Shvets Vladimir Torchilin 1
1.1 Introduction 1
1.2 Stimuli Characteristics for Pathological Tissues (see Table 1.1) 3
1.3 Stimuli Acting from Outside of the Body (sec Table 1.1) 15
1.4 Concluding Remarks 30
References 31
Chapter 2 pH-Sensitive Nanosystems Jun Hu You Han Bae 49
2.1 Introduction 49
2.2 Mechanism of pH-Sensitivity 51
2.3 Representative pH-Sensitive Nanosystems 56
2.4 pH-Sensitive Nanosystems for Drug Delivery 61
2.5 Other Applications of pH-Sensitive Nanosystems 69
2.6 Conclusion and Perspective 73
Acknowledgement 74
References 74
Chapter 3 Matrix Metalloproteinase-Sensitive Nanocarriers Lin Zhu Ting Tu 83
3.1 Introduction 83
3.2 MMTs and their Physiological functions 85
3.3 Up-Regulation of MMPs in Pathological Conditions 86
3.4 Design of MMP-Sensitive Nanosized Drug Delivery and Imaging Systems 87
3.5 Challenges and Future Directions 107
References 108
Chapter 4 Redox-Sensitive Nanosystems J. H. Jeong T. I. Kim J. W. Bae K. D. Park 117
4.1 Introduction 117
4.2 Redox Sensitive Polyethylenimines (PEIs) 119
4.3 Redox Sensitive Polypeptides 124
4.4 Redox-Sensitive Poly(amido amine)s 127
4.5 Redox-Sensitive Polyion Complex (PIC) Micelles 132
4.6 Redox-Sensitive nanogels 133
4.7 Summary and Future Perspective 136
Acknowledgements 136
References 136
Chapter 5 Temperature-Sensitive Pharmaceutical Nanocarriers Gemma Navarro 143
5.1 Introduction 143
5.2 Pharmaceutical Nanocarriers: The Need for Targeted and Triggered Drug Delivery 144
5.3 Passive/Active Targeting of Nanocarriers 146
5.4 Functional Properties of Thermo-Sensitive Polymers and Lipids 149
5.5 Thermo-Sensitive Micelles 153
5.6 Thermo-Sensitive Hydrogels 158
5.7 Thermo-Sensitive Liposomes 159
5.8 Modalities for Hyperthermia Application 167
5.9 Future Perspectives 168
References 168
Chapter 6 Ultrasound-Controlled Nanosystems Shao-Ling Huang Hyunggun Kim Melvin Klegerman David D. McPherson 179
6.1 Introduction 179
6.2 Structure and Properties of Ultrasound Controlled Nanosystems 180
6.3 Active Targeting of Ultrasound-Responsive Nanoparticles 186
6.4 Therapeutic Ultrasound 191
6.5 Therapeuric Applications of Ultrasound-Controlled Nanosystems 194
6.6 Conclusions 200
References 200
Chapter 7 Plasmonic Nanobubble-Controlled On Demand Drug Delivery and Release with High Target Cell Specificity Ekalerina Y. Lukianova-Hleb Dmitri O. Tapotko 213
7.1 Introduction 213
7.2 Generation and Detection of PNBs 215
7.3 Target Cell Specificity of PNB vs. NPS 223
7.4 PNB-Induced Ejection (Release) of an Encapsulated Payload 228
7.5 Therapeutic Responses to Drugs, GNPs, Laser Pulses and X-Rays In Vitro 230
7.6 The Mechanism of Intracellular Self-Amplification of the Therapeutic Strength with Cancer Aggressiveness 233
7.7 Generation and Detection of PNBs In Vivo 234
7.8 The Evaluation of PNB Therapy and Diagnostics In Vivo 237
7.9 Future Medical Applications of PNBs 241
References 243
Chapter 8 Light-Activated Nanopreparations L. A. Wells H. Sheardown 253
8.1 Introduction 253
8.2 Light-Modulated Self Assembly 254
8.3 Photo-Responsive Molecules 255
8.4 Vehicles for Light-Activated Drug Delivery 257
8.5 Challenges 261
8.6 Conclusion 261
References 262
Chapter 9 Magnetic Field-Responsive Nanocarriers Aditi Jhaveri 267
9.1 Introduction 267
9.2 Magnetic Materials and Nanoparticles: A Brief Overview 268
9.3 Magnetic Drug Targeting (MDT) Using Nanocarriers: General Concepts 272
9.4 Magnetically Responsive Nanocarriers for Specific Applications 275
9.5 Multifunctional Magnetic Nanocarriers 292
9.6 Conclusion and Future Perspectives 295
References 296
Chapter 10 Smart Lipid-Based Drug Delivery Systems Paloma Benito-Gallo Pavel Gershkovich Maria Marlow Vanessa Zavn Kishor M. Wasan 309
10.1 Introduction 309
10.2 Smart Lipid-Based Carriers for Systemic Drug Delivery 314
10.3 Smart Lipid-Based Carriers for Oral Drug Delivery 336
10.4 Smart Lipid-Based Carriers for Dermal and Transdermal Delivery 345
10.5 Smart Lipid-Based Carriers for Ocular Delivery 347
10.6 Smart Lipid-Based Carriers for Intramuscular Delivery of Vaccines: Virosomes 349
10.7 Summary 350
Acknowledgements 351
References 351
Chapter 11 Smart Polymer-Based Nanomedicines Jonathan M. Hartley Jindrich Kopecek 373
11.1 Polymer Therapeutics Design and Synthesis 373
11.2 Stimuli 379
11.3 Biorecognition/Biological 384
11.4 Structures of Polymer-Based Nanomedicines 386
11.5 Challenges for Translation 399
References 403
Chapter 12 Inorganic Nanoparticle-Based Smart Drug Delivery Systems Jutaek Nam Sungwook Jung Sekyu Hwang Jaejung Song Sungjee Kim 415
12.1 Introduction 415
12.2 Design Consideration of Inorganic NPs for Delivery Application 416
12.3 Smart Delivery System with Strategic Payload Release 430
12.4 Conclusion 441
References 443
Chapter 13 Smart Nanopreparations for Cancer Shaheen Sultana Shahnaz Sultana 449
13.1 Introduction 449
References 470
Chapter 14 Advances in Smart Nanopreparations for Oral Drug Delivery German A. Islan Maximiliano L. Cacicedo Valeria E. Bosio Guillermo R. Castro 479
14.1 Introduction 479
14.2 Nanopreparations 485
14.3 Conclusions 514
Acknowledgments and Conflict of Interest Statement 514
References 515
Chapter 15 Smart Theranostic Nanosystems Michael Li Ratul Mukerji Kam W. Leong 523
15.1 Introduction 523
15.2 pH-Sensitive Theranostic Nanosystems 523
15.3 Photo-Responsive Systems 530
15.4 Magnetically Responsive Systems 536
15.5 Conclusion 545
Acknowledgement 547
References 547
