Sleep Disorders: Diagnosis and Therapeutics / Edition 1

by S. R. Pandi-Perumal, Joris Verster, Jaime Monti, Salomon Langer

Overview

One of the first such volumes in this field, Sleep Disorders: Diagnosis and Therapeutics explores sleep pharmacology and therapeutics. Leading researchers in the area of experimental and clinical and psychopharmacology critically assess the progress in their specialist fields. The book is suitable as an introduction for clinicians and researchers who are new to sleep pharmacology and outlines the wider range of therapeutic options currently available to them. For seasoned clinicians, the book will assist in selecting the most appropriate methodologies and treatment options designed to circumvent the problems in combating sleep disorders.

Product Details

ISBN-13:	9780415438186
Publisher:	Taylor & Francis
Publication date:	07/23/2008
Pages:	744
Product dimensions:	8.70(w) x 11.50(h) x 1.50(d)

About the Author

S.R. Pandi-Perumal is a Sleep Disorders Specialist at the State University of New York / Downstate Medical Center (SUNY DMC) which is a major provider of medical education, healthcare, and research in the downstate New York region. He is well-recognized sleep researcher both nationally and internationally, and has authored many publications in the field of sleep, dreams, and biological rhythms. He currently holds many professional memberships, including Sleep Research Society, USA and the American Academy of Sleep Medicine, USA. His area of research interest includes sleep and biological rhythms. He has edited many books related to sleep and biological rhythms research and also an editorial member (regular) of Journal of Circadian Rhythms. He was featured in New York Times last year. Joris C Verster is a researcher in Human Psychopharmacology at the Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, the Netherlands. Verster was born in Breda, the Netherlands in 1970. He graduated in 1997 with a major in Biopsychology. In 2002, Verster became a doctor in psychology. Verster has conducted several outstanding studies in human pschopharmacology, including the residual effects of Zaleplon and Zolpidem on driving ability, cognition, memory functioning and psychomotor performance, the day following middle-of-the-night administration. Jaime M. Monti is a Professor of Pharmacology and Therapeutics at the School of Medicine, University of the Republic, Montevideo, Uruguay. He is the director of the Sleep Research Laboratory at the Department of Pharmacology and Therapeutics at the School of Medicine. Prof. Monti received his medical degree from the University of the Republic, and completed a post-doctoral psychopharmacology research training fellowship at the University of Stanford, California, USA. Since 1970, Prof. Monti has published over one hundred and fifty peer reviewed articles and book chapters and twenty invite

Table of Contents

1. Classification of Sleep Disorders 2. Sleep Loss and Sleepiness 3. Approach to the patient with sleep complaint 4. Manifestations of hypersomnia 5. Neuropsychology of Sleep 6. Receptor mechanisms in sleep and wakefulness 7. Transient Insomnia: A Behavioral Sleep Medicine Perspective 8. Chronic insomnia 9. Robound with Hypnotic medication 10. Benzodiazepines: An overview 11. Benzodiazepines: Effects on memory functioning 12. Behavioral therapy, sleep hygiene and psychotherapy 13. Sleep factors 14. The Cytoch P450 enzyme systems: Its relevance to the Pharmacology of sleep 15. Pharmacokinetics: Basic Concepts for dosage regimen considerations 16. Chronopharmacology: Principles and applications in sleep medicine 17. Sleep and Geriatric Psychopharmacology 18. Antihistamines and sleep 19. First generation hypnotics and sedatives 20. GABA-BZD receptors as target for new hypnotics 21. Benzodiazepines: Effects on sleep 22. Indiplon 23. Serotonergic drugs as sleep medications 24. Prostaglandins and sleep/wake regulation 25. Function of endocannabinoids and related compounds in sleep 26. Sleep Medications: When to Prescribe and Rationale for Use 27. Stimulants: Mechanisms and Therapeutic Prospects 28. Zolpidem: its use in the treatment of sleep disorders 29. Eszopiclone: Efficacy and Safety 30. Zaleplon 31. Z-Drugs: Comparative tolerability 32. Rationale for the development of the Z–drugs 33. Metalonin and other indolamines: their involvement in sleep regulation 34. Ramelteon: a Melatonin receptor agonist 35. The rationale for the development of melatonin receptor ligands 36. Schizophrenia, Sleep and Antipsychotic Drugs 37. Interrelationships Between Sleep, Depression and Antidepressant Drugs 38. Effect of antiepileptic medications on sleep architecutre 39. Hormones and sleep 40. Timezone travel, jet lag and sleep disturbances 41. Alcohol, Sleep, Sleep Disorders, and Consequent Daytime Impairment 42. Sleep medication and traffic safety 43. Effect of hypnotic drugs on body balance and standing steadiness 44. Neuropharmacology of Opioids 45. Sleep and Breathing Disorders in Adults 46. Continuous Positive Airway Pressure Therapy 47. Pharmacological Treatment of Obstructive Sleep Apnea 48. Surgical Options in Snoring and Obstructive Sleep Apnea 49. Restless Legs Syndrome: Treatment Options 50. Restless Legs Syndrome: effects on cognitive functioning, memory and psychomotor performance 51. Pharmacological treatment of narcolepsy 52. Modafinil and neuropharmacology of Narcolepsy 53. Narcolepsy: effects on cognitive functioning, memory and psychomotor performance 54. Dreams: Physiology, Pharmacology and Psychology 55. Sleep and Dreaming: Medication effects and side-effects 56. The Subjective Measurement of Excessive Daytime Sleepiness 57. The Multiple Sleep Latency Test and Maintenance of Wakefulness Test: Use and Procedures 58. The OSLER test 59. The Pittsburgh Sleep Quality Index 60. Scoring Rules and General Guidelines for the Pittsburgh Insomnia Rating Scale (PIRS) 61. The Athens Insomnia Scale 62. The Leeds Sleep Evaluation Questionnaire (LSEQ) for psychopharmacology research 63. Sleep Hygiene Practice Scale (SHPS) 64. Cyclic Alternating pattern (CAP) 65. Body Mass Index

Editorial Reviews

Reviewer: M. Isabel L. Crisostomo, MD (Rush University Medical Center)
Description: This self-described pioneering book explores sleep pharmacology and therapeutics.
Purpose: The purpose is to present recent developments in the field of sleep and neuropsychopharmacology with a multidisciplinary perspective.
Audience: This is intended primarily as an introductory book for clinicians and researchers who are new to sleep pharmacology. It is also intended for sleep physicians, psychologists, basic sleep researchers, and generalists. Most of the authors are leading authorities in the field.
Features: The initial chapters are a review of basic sleep concepts. Thereafter, the book delves into various sleep disorders which include insomnia, sleep-disordered breathing, restless legs syndrome, and narcolepsy. For each of these disorders, pharmacologic issues and treatment are discussed. Dreams are also discussed in the last chapters. The scope of the book is certainly extensive in its treatment of sleep pharmacology. In conjunction with the goal of serving as a resource for clinicians, an appendix contains various metrics relevant to sleep. Some chapters are devoted to basic discussions of common sleep disorders, which overlaps with numerous other excellent books on sleep medicine and could have been excluded. Nevertheless, the chapters on pharmacology are extensive enough for the book to stand on its own. There is some degree of overlap in the chapter topics, which the editors acknowledge. Each chapter has a bibliography at the end of the book. The editors indicate in the preface that the 55 chapters are organized into sections, but this is not apparent from the table of contents.
Assessment: This is a significant contribution to the field of sleep medicine. It is one of the first books of its kind that focuses specifically and in depth on sleep neuropsychopharmacology.

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