Serotonin and Behavior

by Jack Barchas (Editor)

Overview

Serotonin and Behavior contains the proceedings of the 1972 symposium on the behavioral effects of changes in brain serotonin, held at Stanford University in California. The papers explore the role of serotonin in behavior as well as the key biochemical and pharmacological issues involved in behavioral studies of severe psychiatric disorders in both humans and animals. The book is organized into eight sections comprised of 65 chapters, with topics ranging from the fundamental biochemistry and pharmacology of the enzymes synthesizing serotonin, particularly, tryptophan hydroxylase and its inhibitors, to the physiology and pharmacology of serotonin. Some papers discuss the link between the telencephalic content of serotonin and pain sensitivity. Other papers focus on the effects of altering serotonin on neurons in the central nervous system. There are chapters that explain the effects of altering serotonin on animal behavior, the relationship between serotonin and sleep, the use of high doses of probenecid to estimate central serotonin turnover in affective disorders and addicts, the behavioral and metabolic effects of L-tryptophan in unipolar depressed patients taking methadone, and amygdala unit activity as a reflection of functional changes in brain serotonergic neurons. Biochemists, pharmacologists, psychiatrists, psychologists, and anyone interested in psychopharmacology will find this book extremely useful.

Product Details

ISBN-13:	9780323143660
Publisher:	Elsevier Science & Technology Books
Publication date:	12/02/2012
Sold by:	Barnes & Noble
Format:	eBook
Pages:	670
File size:	19 MB
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Table of Contents

ContributorsPreclinical Psychopharmacology Research Review CommitteePrefaceWelcoming StatementSession 1. Biochemistry and Pharmacology: Tryptophan Hydroxylase and Inhibitors of Tryptophan Hydroxylase Introduction Does the Total Turnover of Brain 5-HT Reflect the Functional Activity of 5-HT in Brain? Metabolism of p-Chlorophenylalanine and the Molecular Aspects of Its Action Assays and Properties of Tryptophan 5-Hydroxylase Comparative Studies on the Effect of Psrachlorophenylalanine on Hydroxylation of Tryptophan in Pineal and Brain of Rat Physiologic and Drug-Induced Regulation of Serotonin Synthesis Tryptophan Hydroxylase Inhibitors Other than PCPA Some Drug Effects on the Functions of the Two Measurable Forms of Tryptophan-5-Hydroxylase: Influence on Hydroxylation and Uptake of Substrate DiscussionSession 2. Physiology and Pharmacology: Localization, Uptake, and Metabolism of Serotonin Introduction Localization and Transport of Serotonin Serotonin Uptake Systems in Brain Tissue The Role of Serotonin /V-Acetyltransferase in the Adrenergic Regulation of Indole Metabolism in the Pineal Gland Control of Brain 5-HT Content by Dietary Carbohydrates The Normal Occurrence of Tryptamine in Brain and Its Conversion to N-Methyl and N-Dimethyltryptamine in Vitro and in Vivo The Role of Brain Serotonin in the Pharmacologic Effects of the Methyl Xanthines Suppression of Brain Serotonin Synthesis and Metabolism by Benzodiazepine Minor Tranquilizers DiscussionSession 3. Physiology and Pharmacology: Depletion of Serotonin Introduction Serotonin and Convulsions Brain Serotonin and the Pituitary-Adrenal System Relationship between Telencephalic Content of Serotonin and Pain Sensitivity Recent Studies on the Mechanism of Action of Chlorinated Amphetamines An Approach to the Assay of Serotonin Using Gas-Liquid Chromatography and Mass Fragmentography—the Pineal Gland as a Model System Effects of 5,6-Dihydroxytryptamine on Brain Monoamine Neurons in the Rat DiscussionSession 4. Neurophysiology: Effects of Altering Serotonin on Central Nervous System Neurons Introduction Behavioral Pharmacology of p-Chlorophenylalanine (PCPA) The Physiology and Pharmacology of Serotonin Mediated Synapses Direct and Indirect Actions of LSD, Serotonin and Related Compounds on Serotonin-Containing Neurons 5-HT-Containing Neurons: Unit Activity in Behaving Cats Amygdala Unit Activity as a Reflection of Functional Changes in Brain Serotonergic Neurons Serotonergic Receptors in the Central Nervous System The Role of Hypothalamic Serotonin in Thermoregulation DiscussionSession 5. Animal Behavioral Studies: Behavioral Effects of Altering Serotonin in Animals Introduction Effects of Behavioral Manipulations upon Brain Serotonin and Dopamine Effects of PCPA on Fighting Behavior and Habituation of Startle Response in Rats Biochemical and Behavioral Changes in Rats with Experimental Phenylketonuria Effects of Serotonin Depletion on Behavior in Monkeys Effects of Parachlorophenylalanine on the Behavior of Monkeys Changes in Brain Serotonin Level and Male Sexual Behavior DiscussionSession 6. Animal Behavioral Studies—Sleep: The Relation of Serotonin to Sleep Introduction Serotonin and Sleep in the Cat The Effect of flarachlorophenylalanine on Sleep in the Rat: Some Implications for the Serotonin-Sleep Hypothesis The Effect of the Chronic Administration of Parachlorophenylalanine (PCPA) on Sleep Parameters in the Cat Cat Brain Serotonin Content during Sleep and Wakefulness Monoaminergic Systems in the Brain and Their Role in the Sleep States 5-HTP and the Syndrome of Intention or Action Myoclonus as a Sequel to Hypoxic Encephalopathy DiscussionSession 7.