Separations Technology: Pharmaceutical and Biotechnology Applications

by Wayne P. Olson (Editor)

Overview

Authored by a team of respected scientists and technologists, this book covers many pharmaceutical and biotechnology separations methods currently in use. Practical applications and descriptions are offered for air elutriation, microporous filtration, ultrafiltration, phase partitioning, crystallization, and chromatographic technologies such as adsorption, affinity, chelate, ion-exchange, size-exclusion, template, hydrophobic interaction, biotransformations, and chiral separations.

Containing hundreds of references and a complete index, this book is designed for research and development scientists, process optimization engineers, and quality control laboratory scientists as well as quality assurance professionals and others needing to understand current separation techniques.

Product Details

ISBN-13:	9781000725049
Publisher:	CRC Press
Publication date:	02/03/2020
Sold by:	Barnes & Noble
Format:	eBook
Pages:	576
File size:	4 MB

About the Author

Wayne P. Olson, President of Oldevco, Inc., consults to parenteral and biotechnology manufacturers and has lectured on related topics in the United States, Europe, and Japan. His experience at Baxter and other companies includes all aspects of aseptic processing, including analytical, scaleup, process, and validation. His edited or co-edited Interpharm publications include Aseptic Pharmaceutical Manufacturing, Sterile Pharmaceutical Manufacturing, and the forthcoming work, Automated Microbial Identification and Quantitation. Dr. Olson was educated at Cornell University and received his Ph.D. from the University of Illinois at Chicago.

Table of Contents

Separations in Pharmaceutical Manufacturing. Membrane Pervaporation. Tangential Flow Filtration. Supercritical Fluid Extraction/Chromatography. Preparative Separation of Enantiomers. Chromatographic Purification of Recombinant Protein Products. Affinity Chromatography. Monoclonal Antibodies. Immunoaffinity Purification of Proteins for Injection, and the Issue of Animal Viruses. Process Validation of Separation Systems. A Salute to the Human Plasma Processing Industry and Its Founders, E.J. Cohn et al.