RNA and Cancer

by Jane Y. Wu

Overview

Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.

Product Details

ISBN-13:	9783642444852
Publisher:	Springer Berlin Heidelberg
Publication date:	04/13/2015
Series:	Cancer Treatment and Research , #158
Edition description:	2013
Pages:	245
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

Coupling between transcription and alternative splicing.- Detection of alternatively spliced or processed RNAs in cancer using oligonucleotide microarray.- Cancer-associated perturbations in alternative pre-messenger RNA splicing.- Alternative splicing of tumor suppressors and oncogenes.- MicroRNAs in cancer.-The perinucleolar compartment: RNA metabolism and cancer.- Regulation of ARE-mRNA stability by cellular signaling: implications for human cancer.- Alternative pre-mRNA splicing, cell death and cancer.- Oligonucleotide therapeutics in cancer.- Clinical perspective on chemo-resistance and the role of RNA processing.