Protection Against Ischemia/Reperfusion Damage of the Heart

by Yasushi Abiko, Morris Karmazyn

Overview

How to protect against ischemia/reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage-producing mechanism is not yet fully understood. This book provides the latest information on the pathophysiology of ischemia/reperfusion damage and presents new ideas for more effective methods for protection. In the first two sections, the roles of such factors as various ions and phospholipids that modulate ischemia/reperfusion damage are explored, providing a clear and updated explanation of the mechanisms involved. In the third section, the myocardial and vascular remodeling procedure in hearts that have undergone ischemia/reperfusion is explained in terms of signal transduction, enabling a new understanding of the remodeling process. In the final section, a new approach to protection against ischemia/reperfusion damage is presented.

Product Details

ISBN-13:	9784431684848
Publisher:	Springer Japan
Publication date:	03/21/2012
Edition description:	Softcover reprint of the original 1st ed. 1998
Pages:	248
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

I: Modulators of Ischemia/Reperfusion Damage: H+, Na+, and Ca2+.- Regulatory Mechanism of NHE1 Isoform of Na+/H+ Exchanger in Cardiac and Other Tissues.- Role of the Vacuolar Proton Pump in Preconditioning.- Role of the Na+/Ca2+ Exchanger in Intracellular Ca2+ Overload During Ischemia and Reperfusion.- The Role of Sodium-Hydrogen Exchange in the Ischemic and Reperfused Myocardium.- II: Modulators of Ischemia/Reperfusion Damage: Lipid Metabolites.- Effects of Lysophosphoglycerides on KATP Channels in Cardiac Ventricular Cells: Blockage or Run-down?.- Lysophosphatidylcholine: A Possible Modulator of Ischemic Injury in the Heart.- Potential Role of Phospholipase A2 in the Normoxic, Ischemic, and Reperfused Heart.- Effects of Lysophosphatidylcholine on Ion Transporters in the Heart.- III: Molecular Mechanisms of Myocardial and Vascular Remodeling in the Ischemic Heart.- Molecular Mechanism of Cardiovascular Remodeling.- Osteopontin as a Coordinator of Stress-Induced Host Responses: Molecular Analysis of Its Interaction with Various Ligands.- Coronary Reperfusion and Cytokines.- Brief Ischemia/Reperfusion Activates Transcellular Signaling Cascades and Leads to Proto-Oncogene Expression and Growth Factor Production.- IV: New Therapeutic Strategy to Attenuate Ischemia/Reperfusion Damage.- Ischemia/Reperfusion Injury and Ion Channel Blockade.- Energy Ameliorants: A New Category of Antianginal Drugs.- Strategy Toward Warm Heart Cardioplegia: Our Experimental and Clinical Experience.

Editorial Reviews

Reviewer: Ruben Mestril, PhD (Loyola University Medical Center)
Description: This book is a compendium of papers presented at the Satellite Symposium "Protection Against Ischemia/Reperfusion Damage" prior to the 14th annual meeting of the Japanese section of the ISHR on July 17, 1997. It consists of a series of studies contributed by an international group of investigators, including both editors. The title of the book is slightly misleading, since the reports only cover a limited selection of the research areas involved in the study of ischemia/reperfusion damage. Nonetheless, given the breath of this particular field of research, certain omissions are unavoidable.
Purpose: The main purpose is to facilitate a better understanding of the research involved in the pathophysiology of ischemic and reperfusion damage. In addition, the last portion of the book highlights some of the emerging new therapeutic strategies to attenuate the consequences of ischemia/reperfusion injury.
Audience: This book will be of great interest to both physicians involved in the clinical management of patients with ischemic heart disease and investigators in the field of cardiovascular research. It is an excellent snapshot of our present day knowledge of cardiac ischemia and reperfusion damage.
Features: The contributions clearly present the work on some of the major modulators of ischemic and reperfusion damage, such as the different ion exchangers (Part I) and lipid metabolites (Part II). The role that the different molecular signals, such as cytokines, angiotensin II, and proto-oncogenes play in the remodeling of the ischemic heart are covered particularly well in Part III. Finally, Part IV explores some of the experimental techniques that promise the development of new therapeutic strategies for the management of patients with ischemic heart disease.
Assessment: This book presents a comprehensive collection of state of the art studies on the subject of ischemia and reperfusion injury research. The newcomer to this field will find it a valuable resource while the seasoned researcher will find it an excellent reference.

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