Prognostic Factors in Cancer / Edition 1

by Paul Hermanek, Mary K. Gospodarowicz, Donald E. Henson, Robert V.P. Hutter, Leslie H. Sobin

Overview

M. K. Gospodarowicz, P. Hermanek, and D. E. Henson Attention to innovations in cancer treatment has tended to eclipse the importance of prognostic assessment. However, the recognition that prognostic factors often have a greater impact on outcome than available therapies and the proliferation of biochemical, molecular, and genetic markers have resulted in renewed interest in this field. The outcome in patients with cancer is determined by a combination of numerous factors. Presently, the most widely recognized are the extent of disease, histologic type of tumor, and treatment. It has been known for some time that additional factors also influence outcome. These include histologic grade, lymphatic or vascular invasion, mitotic index, performance status, symptoms, and most recently genetic and biochemical markers. It is the aim of this volume to compile those prognostic factors that have emerged as important determinants of outcome for tumors at various sites. This compilation represents the first phase of a more extensive process to integrate all prognostic factors in cancer to further enhance the prediction of outcome following treatment. Certain issues surround­ ing the assessment and reporting of prognostic factors are also considered. Importance of Prognostic Factors Prognostic factors in cancer often have an immense influence on outcome, while treatment often has a much weaker effect. For example, the influence of the presence of lymph node involvement on survival of patients with metastatic breast cancer is much greater than the effect of adjuvant treatment with tamoxifen in the same group of patients [5].

Product Details

ISBN-13:	9783540586883
Publisher:	Springer Berlin Heidelberg
Publication date:	08/25/1995
Series:	UICC International Union Against Cancer
Edition description:	New Edition
Pages:	290
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Hermanek, P., PhD, MD (Univ of Erlangen-Nurnberg); Gospodarowicz, Mary K., MD (Univ of Toronto); Henson, D. E., MD (National Cancer Institute); Hutter, R. V.P., MD (Univ of Medicine and Dentistry of New Jersey); Sobin, L. H., MD (Uniformed Services Univ of the Health Sciences)

The contributors represent the specialties of obstetrics and gynecology, oncology, radiation oncology, otolaryngology, pathology, surgery, and urology. Most are from universities, hospitals, and research institutions in the U.S., Canada, Italy, Germany, Japan, and Switzerland. Institutions prominently represented include National Institute for Cancer Research, Univ "La Sapienza" di Roma, National Cancer Centre Hospital in Japan, Univ of Erlangen in Germany, Armed Forces Institute of Pathtology, and Georgetown Univ.

Table of Contents

1 Introduction.- 2 Squamous Cell Carcinoma of the Head and Neck.- 3 Parotid Carcinoma.- 4 Thyroid Carcinoma.- 5 Oesophageal Carcinoma.- 6 Stomach Carcinoma.- 7 Colorectal Carcinoma.- 8 Anal Canal Carcinoma.- 9 Hepaellular Carcinoma.- 10 Carcinoma of the Gallbladder.- 11 Carcinoma of the Extrahepatic Bile Ducts.- 12 Exocrine Pancreatic Carcinoma.- 13 Lung Carcinoma.- 14 Osteosarcoma.- 15 Soft Tissue Sarcomas in Adults.- 16 Skin Carcinoma.- 17 Malignant Melanoma of Skin.- 18 Breast Carcinoma.- 19 Vulvar Carcinoma.- 20 Cervix Uteri Carcinoma.- 21 Corpus Uteri Carcinoma.- 22 Fallopian Tube Carcinoma.- 23 Ovarian Cancer.- 24 Prostate Carcinoma.- 25 Testicular Germ Cell Tumors.- 26 Renal Cell Carcinoma.- 27 Urinary Bladder Carcinoma.- 28 Ophthalmic Tumours.- 29 Neuroepithelial Tumours of Brain.- 30 Hodgkin Disease.- 31 Non-Hodgkin Lymphomas.

Editorial Reviews

"The efforts of the UICC, the editors and contributors are to be commended for publishing this important and progressively evolving scientific endeavour on prognostic assessment" - Cancer Forum

From the Publisher