Principles of Nucleic Acid Structure / Edition 2

by Stephen Neidle

Overview

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software.

Product Details

ISBN-13:	9780123695079
Publisher:	Elsevier Science
Publication date:	10/15/2007
Edition description:	2nd ed.
Pages:	302
Product dimensions:	7.25(w) x 10.25(h) x (d)

About the Author

Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Table of Contents

Methods for Studying Nucleic Acid Structure.
The building-blocks of DNA and RNA.
DNA Structure as Observed in Fibres and Crystals.
DNA-DNA recognition: non-standard and higher-order DNA structures.
Principles of small molecule-DNA Recognition.
The RNA structural world.
Principles of Protein-DNA Recognition.

What People are Saying About This

From the Publisher

Practical resource that provides a complete and concise summary of the underlying principles and approaches to studying nucleic acid structure

Editorial Reviews

Review of the previous edition:
"Stephen Neidle's excellent new introductory textbook will prove to be very timely, and provides a calm, balanced and objective study of the major advances." —Crystallography News

From the Publisher