Pharmacotherapy of Pulmonary Hypertension

Pharmacotherapy of Pulmonary Hypertension

ISBN-10:
3662521571
ISBN-13:
9783662521571
Pub. Date:
08/23/2016
Publisher:
Springer Berlin Heidelberg
ISBN-10:
3662521571
ISBN-13:
9783662521571
Pub. Date:
08/23/2016
Publisher:
Springer Berlin Heidelberg
Pharmacotherapy of Pulmonary Hypertension

Pharmacotherapy of Pulmonary Hypertension

Paperback

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Overview

This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.


Product Details

ISBN-13: 9783662521571
Publisher: Springer Berlin Heidelberg
Publication date: 08/23/2016
Series: Handbook of Experimental Pharmacology , #218
Edition description: Softcover reprint of the original 1st ed. 2013
Pages: 576
Sales rank: 855,597
Product dimensions: 6.10(w) x 9.25(h) x 0.05(d)

Table of Contents

Preface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models.- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors.- Part III. Pulmonary hypertension: novel pathways and emerging therapies   Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy.- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.

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