Pharmacotherapy of Obesity: Options and Alternatives / Edition 1

by Karl G. Hofbauer, Ulrich Keller, Olivier Boss

Overview

Primarily intended for physicians and health care professionals who are treating obese patients, this book explores current and future options for drug treatment of obesity puts them into perspective against available alternative treatments. Distinguished scientists and clinical investigators provide reviews of each individual topic, covering a wide range of subjects from pathophysiology of obesity to the benefits of weight loss. The core sections on pharmacotherapy deal with currently available drugs and drugs in pre-clinical development, complemented with sections on non-drug treatment and general therapeutic aspects to provide an integrated view of therapeutic approaches to the treatment of obesity and its associated syndromes.

Product Details

ISBN-13:	9780367394165
Publisher:	Taylor & Francis
Publication date:	09/23/2019
Pages:	504
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Hofbauer, Karl G.; Keller, Ulrich; Boss, Olivier

Table of Contents

Part I Pathophysiology of Obesity

1 Energy Homeostasis Eric Ravussin Leslie P. Kozak 3

2 The Pathophysiology of Appetite Control Jason C. G. Halford John E. Blundell 25

3 Genetics of Obesity Philippe Boutin Philippe Froguel 53

4 Antipsychotic Drugs, Weight Gain, and Diabetes Trino Baptista 69

Part II General Therapeutic Aspects

5 Obesity and Associated Complications Michael Hamilton Frank Greenway 87

6 Psychosocial Aspects of Obesity Esther Biedert Jürgen Margraf 119

7 Basic Considerations and Guidelines for Treatment Michael E. J. Lean 139

Part III Benefits of Weight Loss

8 Weight Loss and Cardiovascular Risk Factors Tobias Pischon James D. Douketis Arya M. Sharma 155

9 Weight Loss and Associated Diseases Paolo M. Suter 173

10 Weight Loss and Metabolic Diseases F. Xavier Pi-Sunyer 195

Part IV Drugs on the Market

11 Orlistat Hans Hauner 219

12 Sibutramine Donna H. Ryan 245

13 Noradrenergic, Serotonergic, Antiepileptic, and Herbal Drugs George A. Bray 267

14 Adverse Effects and Drug-Drug Interactions Stephan Krähenbühl 285

Part V Drugs in Research and Development

15 Central Targets for Antiobesity Drugs Rexford S. Ahima Suzette Y. Osei 299

16 Leptin and Other Appetite Suppressants L. Arthur Campfield Françoise J. Smith 321

17 Peripheral Targets for Antiobesity Drugs Vivion E. F. Crowley Antonio J. Vidal-Puig 345

18 Targeting Thermogenesis in the Development of Antiobesity Drugs Mary-Ellen Harper Robert Dent Frederique Tesson Ruth McPherson 363

Part VI Treatment Alternatives

19 Diet, Physical Activity, and Behavior Alexandra Kazaks Judith S. Stern 387

20 Dietary Supplements and Herbal Preparations Abdul G. Dulloo 405

21 Surgical Treatment of Obesity Jaroslaw Kolanowski 421

22 Efficacy of Different Antiobesity Interventions Rolf Stöckli Ulrich Keller 435

23 Integrated Approach to Treatment and Prevention André J. Scheen 449

Part VII Appendix

Perspectives and Outlook Karl G. Hofbauer Ulrich Keller Olivier Boss 467

Index 473

Editorial Reviews

3 Stars from Doody

Reviewer: Ruben D Bunag, MD, MA Pharmacology(University of Kansas Medical Center)
Description: This is a comprehensive and up-to-date review of the various causes contributing to the worldwide prevalence of obesity. Written by authors with long-standing interests in obesity-related research, relevant information is presented under six headings: pathophysiology of obesity, general therapeutic aspects, benefits of weight loss, drugs on the market, drugs in research and development, and treatment alternatives. Information in each section is amply supported by the latest research references.
Purpose: The book is written primarily for physicians and healthcare professionals who treat obese patients. Because of the increasing prevalence of obesity, this book will be a useful resource for all interested investigators. It clearly accomplishes the authors' objectives.
Audience: The book is written for physicians, healthcare professionals, pharmacists, research scientists in academia or industry, and other students of life sciences related to obesity. It should provide a comprehensive and useful source of the latest developments in obesity research. The authors are well established and recognized authorities on obesity.
Features: The book begins with a logical presentation of the pathophysiology of obesity that includes discussions of energy homeostasis, appetite control, genetics, and antipsychotic drugs. This is followed by consideration of general therapeutics on obesity-associated complications, psychosocial aspects, and basic guidelines for treatment. Next is a general discussion of weight loss relating to cardiovascular risk factors, associated diseases, and metabolic diseases. The last three sections discuss the currently available drugs, drugs under development, and treatment alternatives.
Assessment: This book provides a more comprehensive and up-to-date review than others that have been published previously on obesity.

Doody's Review Service