Pharmaceutical Biocatalysis: Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases / Edition 1

by Peter Grunwald

Overview

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-"designer" approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Product Details

ISBN-13:	9789814800617
Publisher:	Jenny Stanford Publishing
Publication date:	06/26/2019
Series:	Jenny Stanford Series on Biocatalysis
Pages:	800
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Peter Grunwald studied chemistry at the Universities of Saarbrücken and Hamburg, Germany. He graduated in the field of high-frequency spectroscopy and then became a staff member of the Institute of Physical Chemistry. After receiving his PhD in physical chemistry, he founded a biotechnology research group. He was appointed professor in 2001. His research interests focus on immobilized biocatalysts, kinetics of enzymes in organic solvents, and interactions between biocatalysts and heavy metal ions. Prof. Grunwald is also interested in chemical education, including curriculum development. He has authored a textbook on biochemistry and is an editorial board member of Catalysts.

Table of Contents

Pharmaceuticals: Some General Aspects Use of Enzymes in the Downstream Processing of Biopharmaceuticals Therapeutic Use of Carbonic Anhydrase Inhibitors and Their Multiple Drug Interactions Fibrinolytic Enzymes for Thrombolytic Therapy Role of Engineered Proteins as Therapeutic Formulations Synthesis of bioactive peptides for pharmaceutical applications Cardiovascular Disease and Oxidative Stress Enzymatic Amino Acid Deprivation Therapies Targeting Cancer Carboxylesterase inhibitors: Relevance for Pharmaceutical Applications Molecular Aspects of the Activity and Inhibition of the FAD-containing Monoamine Oxidases Multifunctional Monoamine Oxidase and Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease The Neurodegenerative Characteristics of Alzheimer’s Disease and Related Multi-Target Drug Design Studies Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism Cytochrome P450 Enzymes for the Synthesis of Novel and Known Drugs and Drug Metabolites Cytochromes P450, Cardiovascular Homeostasis and Disease Protein Degradation Inducers SNIPERs and PROTACs against Oncogenic Proteins Resistance Mechanisms of Tumor Cells Biocatalytic Nanoreactors for Medical Purposes Computer-Aided Drug Design for the Identification of Multi-Target Directed Ligands (MTDLs) in Complex Diseases: An Overview The Development of Improved Therapeutics through a Glycan-‘Designer’ Approach On Biocatalysis as Resourceful Methodology for Complex Syntheses: Selective Catalysis, Cascades, and Biosynthesis

Editorial Reviews

Reviewer: Rahmat M. Talukder, PhD, RPh (The University of Texas at Tyler)
Description: In this fourth volume of the Jenny Stanford Series on Biocatalysis, the authors provide scientific perspectives on how biocatalysts can be used for the development of new drugs and be employed in the treatment of certain diseases. The author gives a brief synopsis of each chapter in the preface, which should be useful to readers.
Purpose: This book offers an overview of therapeutic enzymes and enzyme inhibitors. There has been an increasing trend in the development of biologics for therapeutic purposes. The development of biologics requires expertise in enzymology and biocatalysts. This book provides fundamentals and some examples of therapeutic enzymes and enzyme inhibitors.
Audience: While the editor has not specifically indicated a target audience, it is apparent that the scientists working in the field of therapeutic enzymes will find this a useful reference. Contributors to the book include some well-known scientists and academicians.
Features: This book covers a wide range of topics related to enzymes and their application in the development of pharmaceuticals in its 21 chapters. The discussions in many chapters include scientific perspectives with relevant examples, such as the use of engineered proteins and fibrinolytic enzymes for thrombolytic therapy. In one chapter, the application of rDNA technology to the synthesis of bioactive proteins and peptides is described moderately well. A few chapters deal with the role of enzymes in certain disease conditions, such as cardiovascular disease, neurodegenerative diseases, etc. The book also offers insights into some of the disease-related proteins including oncogenic proteins and their role in tumor growth. Along with that, it offers discussions of current research that have shown positive results as well as the challenges in treating those conditions. There is a chapter that presents a brief overview of the current understanding of resistance mechanisms of tumor cells. Moreover, there are discussions on computer-aided drug design; application of biocatalysis in the production of pharmaceuticals. The fundamental aspects of enzymes as pharmaceuticals are well presented in this book. The discussions include information related to the world pharmaceutical market, regulatory bodies, quality standards, cost of drug development, and orphan drugs. Peptides and peptidomimetic drugs are used in various conditions including cancer, skin conditions, and infections. Peptide synthesis, purification, and characterization are briefly discussed in a chapter. Although the book covers a wide range of topics related to pharmaceutical biocatalysis, some topics could have been discussed in greater detail. A separate chapter on reactions catalyzed by various types of biocatalysts would have been useful. Most of the illustrations are of good quality, but some could have been much better.
Assessment: Due to its environmental friendliness, biocatalysis has been emerging as an alternative approach to chemical synthesis of pharmaceuticals as well as other relevant molecules. Written by scientists from around the world, this book presents recent advances in the field of enzymes and their uses in pharmaceuticals. To develop compounds in a cost-effective manner, biocatalytic processes must be efficient. Thus, this book could have been enriched by providing some insights into the development of efficient and self-sufficient biocatalytic processes.

Doody's Review Service

This book is an important addition to the literature in this field. It not only summarizes the importance of enzymes as targets for pharmaceutical drug research in the past but also shows that there is still enormous potential in the future. Motivated by Peter Grunwald, a large group of experts have shared their specialist knowledge. The book a treasure for anyone working or doing research in the field.”
Prof. Theo Dingermann, Goethe University, Germany
“This book represents an outstanding scientific work. It covers the state of the art, challenges, and key achievements of research focusing on the use of enzymes for therapeutic purposes. It discusses the fundamentals of enzyme function and its applications and shows how this fantastic research field has been explored in drug discovery and innovation for gaining a better understanding of enzymes and their use for a better quality of life.”
Prof. Cláudio Viegas Jr., Universidade Federal de Alfenas, Brazil

From the Publisher