Perinatal Stem Cells: Biology, Manufacturing and Translational Medicine

by Zhong Chao Han (Editor), Tsuneo A. Takahashi (Editor), Zhibo Han (Editor), Zongjin Li (Editor)

Overview

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury.

Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Product Details

ISBN-13:	9789811327032
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/06/2019
Sold by:	Barnes & Noble
Format:	eBook
File size:	12 MB
Note:	This product may take a few minutes to download.

About the Author

Zhong Chao Han is a professor and director at the State Key Lab of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences; Tsuneo A Takahashi is a visiting professor at the Institute for Frontier Medical Sciences, Kyoto University; Zhibo Han is an associate professor at the State Key Lab of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences.

 

Table of Contents

Chapter 1. Introduction of perinatal tissue-derived stem cells.- Chapter 2. The regenerative and reparative potential of amniotic membrane stem cells.- Chapter 3. The stemness of perinatal stem cells.- Chapter 4. Quality Assessment of Umbilical Cord Tissue in Newborn Stem Cell.- Chapter 5. Safety and Genetic Stability of Cultured Perinatal Mesenchymal Stem Cells.- Chapter 6. Therapeutic application of perinatal mesenchymal stem cells in nervous system diseases.- Chapter 7. Umbilical cord blood as a source of novel reagents and therapeutics.- Chapter8. The characteristics and therapeutic application of perinatal mesenchymal stem cells derived exosomes.- Chapter 9. Therapeutic application of perinatal mesenchymal stem cells in diabetes mellitus.- Chapter 10. Perspective of therapeutic angiogenesis using Circulating Endothelial Progenitors from umbilical cord blood.- Chapter 11. Proangiogenic Features of Perinatal Tissue Derived Stem Cells in Cardiovascular Disease Therapy.- Chapter 12. Perinatal Stem Cells in Kidney Regeneration: Current Knowledge and Perspectives.- Chapter 13. Prenatal mesenchymal stem cell secretome and its clinical implication. 

Editorial Reviews

Reviewer: Joanna Goral, PhD (Midwestern University)
Description: This is an introduction to the various types of perinatal stem cells and their potential uses in the treatment of diseases or injuries.
Purpose: The purpose is to describe the different types of perinatal stem cells (PSCs) and to highlight the features that make them suitable for regenerative medicine applications, along with issues concerning the quality control and cGMP manufacture of PSCs.
Audience: The purpose is to describe the different types of perinatal stem cells (PSCs) and to highlight the features that make them suitable for regenerative medicine applications, along with issues concerning the quality control and cGMP manufacture of PSCs.
Features: The chapters characterize the different types of PSCs derived from perinatal discarded tissues, such as the placenta, umbilical cord, cord blood, amniotic membrane, and amniotic fluid. They emphasize the therapeutic advantages of using PSCs over adult stem cells, embryonic stem cells (ESCs), and pluripotent stem cells (iPSCs), including the high yield and decreased risk for tumorigenicity and immune rejection. Several clinical applications using the regenerative abilities of PSCs are presented throughout the book. Finally, issues related to reproducibility, stability, quality control, and manufacturing of clinical-grade PSCs are presented.
Assessment: This book provides an excellent review of PSCs, including sufficient background information for the different types of PSCs, along with isolation and expansion techniques, and potential therapeutic applications to cure human diseases. Each chapter provides a concise introduction to the field for students and researchers in the biomedical sciences, then delves deeper into the technical details that are of interest to scholars working in the area of regenerative medicine and stem cells. The addition of available clinical trials outcomes would have been a valuable resource to readers.

Doody's Review Service

The book offers detailed insights into the sources of perinatal stem cells and how to derive, multiply and store them. It is intended for researchers in stem cell biology, tissue engineering, regenerative medicine, and students in developmental/stem cell biology. … perinatal tissue derived mesenchymal stem cells are expected to play an important role, along with massive vaccination campaigns, in restoring human health in the coming years.” (Manuela Monti, European Journal of Hishemistry, Vol. 65, 2021)

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