Pellock's Pediatric Epilepsy: Diagnosis and Therapy / Edition 4

by John M. Pellock MD, Douglas R. Nordli Jr. MD, Raman Sankar MD, PhD, James W. Wheless MD

Overview

Now in its fourth edition, Pellock's Pediatric Epilepsy: Diagnosis and Therapy remains the gold standard for diagnosis, treatment, classification,and management of childhood epilepsies. With over 100 distinguished contributors from world-leading epilepsy programs, the long-awaited new editionmaintains the breadth and scope the book is known for while significantly updating the science, practice, and therapeutic strategies that continue to movethe field forward.

At the center of this new edition is the totally reorganized and expanded section on age-related syndromes. There is a major emphasis on new genetic-basedclassifications and the clinical implications for identifying and managing the various subtypes. New chapters devoted exclusively to Panayiotopoulossyndrome, myoclonic status epilepticus, and autosomal dominant focal epilepsies, among others, cover even more ground than the last edition. Brand-newchapters in the drug and diet section cover perampanel, ezogabine, and lacosamide, while the existing chapters on major medical treatments have beencomprehensively updated to reflect the latest trials and studies. Other sections contain new chapters on genetics, non-invasive functional mapping, sleepissues for pediatric epilepsy patients, and more.

With more than 80 chapters, Pellock's Pediatric Epilepsy now contains a full discussion of the spectrum of epilepsy disorders, not just seizures.From basic mechanisms and epidemiology, through diagnosis and therapy, to quality of life issues, the new edition of this established reference coversevery aspect of childhood epilepsy and will continue to be the definitive core text for all professionals involved in the field.

New to the Fourth Edition:

• Every chapter thoroughly reviewed, revised, and updated
• Section on age-related syndromes completely reconfigured to align with new ILAE terminology and organization in classifying seizures and forms ofepilepsy
• Major update on disease mechanisms and all treatments for epilepsy, including drugs
• Increased attention to special populations, including a heavily-updated chapter on the female epilepsy patient
• New final section covers the epilepsy spectrum, with new chapters on epilepsy and sleep, co-morbidities of childhood, behavioral influence of AEDs,and transitioning to adulthood
• Purchase includes access to the fully-searchable downloadable e-book.

Product Details

ISBN-13:	9781620700730
Publisher:	Springer Publishing Company
Publication date:	08/24/2016
Edition description:	4th ed.
Pages:	1200
Product dimensions:	8.80(w) x 11.30(h) x 1.80(d)

About the Author

John M. Pellock, MD, is Chairman of the Division of Child Neurology, Vice Chairman of the Department of Neurology and Professor of Neurology, Pediatrics, Pharmacy and Pharmaceutics at the Medical College of Virginia, Virginia Commonwealth University Health System, in Richmond, Virginia.

Douglas R. Nordli, Jr., MD, is the Lorna S. and James P. Langdon Chair of Pediatric Epilepsy at Northwestern University School of Medicine and Director, Children's Memorial Epilepsy Center at Children's Memorial Hospital.

Raman Sankar, MD, PhD, is Professor and Chief of Pediatric Neurology and Rubin Brown Distinguished Chair at David Geffen School of Medicine at UCLA.

James W. Wheless, MD, Professor and Chief of Pediatric Neurology, LeBonheur Chair, Division of Pediatric Neurology, University of Tennessee Health Science Center, Memphis, Tennessee

Table of Contents

Basic Mechanisms; Pathophysiology of Seizures and Epilepsy in the Immature Brain: Cells, Synapses, and Circuits; Neuronal Networks in Epilepsy and Neuronal Excitability; Epileptic Channelopathies; Metabolic and Pharmacologic Consequences of Seizures; The Pathology of Epilepsy; Epileptic Cerebral Cortical Malformations; Genetic Influences on Risk for Epilepsy; Classification, Epidemiology, Etiology, and Diagnosis; Classification of Epilepsies in Childhood; Epidemiology of Epilepsy in Children; An Approach to the Child with Paroxysmal Phenomena with Emphasis on Nonepileptic Disorders; Evaluating the Child with Seizure; The Use of Electroencephalography in the Diagnosis of Epilepsy in Childhood; Basics of Neuroimaging in Pediatric Epilepsy; Age-Related Syndromes; Neonatal Seizures; Severe Encephalopathic Epilepsy in Early Infancy; West Syndrome; Myoclonic Epilepsies of Infancy; Partial Epilepsies in Infancy; Febrile Seizures; Generalized Epilepsies with Febrile Seizures; Lennox-Gastaut Syndrome; Childhood Absence Epilepsies; Benign Focal Epilepsies of Childhood; Landau-Kleffner Syndrome; Idiopathic Generalized Epilepsies of Adolescence; Progressive Myoclonus Epilepsies; Localization-Related Epilepsies: Simple Partial Seizures, Complex Partial Seizures, and Rasmussen Syndrome; Selected Disorders Associated with Epilepsy; General Principles of Therapy; Treatment Decisions in Childhood Seizures; Comparative Anticonvulsant Profile and Proposed Mechanisms of Action of Antiepileptic Drugs; Evidence-Based Medicine Issues Related to Drug Selection; Combination Drug Therapy; Adverse Effects of Antiepileptic Drugs, Drug-Related Seizure Exacerbation, and Monitoring of Therapy; Status Epilepticus and Acute Seizures; Epilepsy and Child-Bearing (Fetal Effects); Teratogenic Effects of Epileptic Medications; Pharmacokinetic Principles of Antiepileptic Therapy in Children; Dosage Form Considerations in the Treatment of Pediatric Epilepsy; Drug Interations; Antiepileptic Drugs and Ketogenic Diet; ACTH and Steroids; Benzodiazepines; Carbamazepine and Oxcarbazepine; Ethosuximide, Methsuximide, and Trimethadione; Felbamate; Gabapentin and Pregabalin; Lamotrigine; Levetiracetam; Pheonbarbital and Primidone; Phenytoin and Related Drugs; Sulthiame; Tiagabine; Topiramate; Valproate; Vigabatrin; Vitamins, Dietary Considerations; and Alternative Therapies; Zonisamide; The Ketogenic Diet; Immunotherapy Issues, Antiepileptic Drugs in Development; Epilepsy Surgery and Vagus Nerve Stimulation; Neurophysiologic Evaluation; Advanced Imaging Evaluation; Surgical Treatment: Surgery and Outcome; Outcome of Surgery in Children; Vagus Nerve Stimulation Therapy in Pediatric Patients: Uses and Effectiveness; Psychosocial Aspects; Costs of Pediatric Epilepsy; Quality of Life in Children with Epilepsy; Epilepsy, Cerebral Palsy, and IQ; Cognitive and Psychiatric Co-Morbidities and Educational Placement; Cognitive Side Effects of Antiepileptic Drugs; Migraine and Epilepsy.

Editorial Reviews

Reviewer: Lawrence W Brown, MD (The Children's Hospital of Philadelphia)
Description: This is the fourth edition of the standard guide to the principles and practice of pediatric epilepsy. This update includes a revised section on age-related syndromes that correspond with the latest ILEA (International League Against Epilepsy) guidelines, major updates on mechanisms of disease and all approaches to treatment including new medications, and new chapters on the relationship between epilepsy and sleep, behavior comorbidities, and medical transition to adulthood. The first edition was published in 1993.
Purpose: This book has matured into a comprehensive approach to pediatric epilepsy, from the basic science underpinning diagnosis, analysis of all current and emerging treatment models, and careful correspondence to evolving international terminology. It is authored by many eminent, internationally recognized experts in the field.
Audience: The intended audience is all clinicians and scientists interested in a full understanding of the complexity of seizure disorders in childhood. It is equally valuable to general pediatricians and neurologists, trainees in child neurology, and experienced pediatric epileptologists.
Features: There is a logical progression from a comprehensive discussion of basic mechanisms that explore the pathophysiology of seizures in the developing brain to an up-to-date review of neurogenetics and the concept of epileptic networks. After a brief review of epidemiology and a general introduction to diagnosis and use of EEG, there is a well-organized section on age-related epilepsy syndromes, clear discussion of general principles, succinct overview of all available and emerging treatments (including drugs, diets, devices, and alternative approaches), and a new section emphasizing areas contributing to quality of life not previously addressed.
Assessment: Dr. Jack Pellock, who died in 2016, was a giant among pediatric neurologists. He was the consummate triple threat of clinician, researcher, and educator. His annual course on pediatric epilepsy that trained generations of young clinicians, and his innumerable clinical drug trials, his leadership of numerous consensus statements summarizing the latest knowledge in the field led to this book, which has been growing for almost 25 years and which has become the standard for the field of pediatric epilepsy. As with any multiauthored book with four section editors, there are limitations and overlaps. For example, electrical status epilepticus of sleep is covered in at least four chapters, some of which are cross-referenced, but not all even make it into the index. The contributors are mostly true experts who can also write clearly. Among the best parts of the book are a short section on generic drugs that explains the basis of what has come to dominate the pharmaceutical industry; the chapter on evidence-based medicine and its application to pediatric epilepsy, which summarizes its value and limitations; and the brief section on the role of EEG, which simply ends asking six questions that define the potential of the technology. For those of us to struggle to keep up with basic neuroscience and advances in epilepsy genetics, they are a crash course that appears to have been written yesterday - a remarkable feat in such a rapidly changing landscape. Overall, this 1,200-page book has accomplished what few books can do - usually they are either too detailed for casual readers and too limited and outdated to answer a specific question. This book pulls a rabbit out of the hat and satisfies both. It is a tribute to the genius of Dr. Pellock and a fitting legacy.

Doody's Review Service

5 Stars! from Doody