Pathophysiology of Plasma Protein Metabolism

by Giulian Mariant (Editor)

Overview

This book represents a factual account of the proceedings of an international symposium on the pathophysiology of plasma protein metabolism, which was organised in October 1982 by the Plasmaprotein and Immunology Division of the C.N.R. Institute of Clinical Physiology at the University of Pisa (Italy). Several of the contributors are former members of the International Study Group on Plasma Protein Metabolism, the last meeting of which was held in Turin (Italy) in 1974, under the auspices of the scientific organisation of the same institute. The symposium took the form of a series of lectures, with the main objective of providing a positive contribution to the state of the art of several topics related to the kinetic and pathophysiological factors regulating the synthesis, distribution and degradation of plasma proteins. The first four chapters form a group, each one considering a special aspect of the kinetics of turnover and distribution of plasma proteins in general; particular attention is paid to the recent advances in the field of kinetic modelling, the choice of the best models and the optimisation of the experimental designs. The next seven chapters consider the regulation of synthesis, distribution and catab­ olism of various classes of plasma proteins including albumin, immunoglobulins, complement fractions and acute-phase proteins. The remaining chapters deal with metabolic studies of various plasma proteins (including tumour markers, coagUlation proteins and lipoproteins) in different disease states, such as malig­ nancies, coagulative disorders, malnutrition and the extensive group of athero­ sclerotic cardiovascular diseases.

Product Details

ISBN-13:	9781461297222
Publisher:	Springer US
Publication date:	10/02/2011
Edition description:	Softcover reprint of the original 1st ed. 1984
Pages:	402
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1 Large Models in the Study of Protein Metabolism.- 2 Optimal Experiment Design in Plasma Protein Metabolic Studies: Sequential Optimal Sampling Schedules for Quantifying Kinetics.- 3 Formulation, Identification and Validation of Mathematical Models for Plasma Protein Metabolic Studies.- 4 Kinetic Modelling for Distribution and Removal of Plasma Proteins with Altered Biological Behaviour in vivo.- 5 Regulation of the Interstitial Distribution of Plasma Proteins.- 6 In vivo and in vitro Regulation of Albumin Synthesis.- 7 In vitro and in vivo Regulation of Immunoglobulin Synthesis.- 8 IgA Immunoglobulin Synthesis, Catabolism and Transport.- 9 Regulation of Retained and Secreted Liver Proteins.- 10 Metabolism of Radiolabelled Complement Proteins in Health and Disease.- 11 Metabolic Studies of Acute-phase Proteins.- 12 Significance of in vivo and in vitro Metabolic Studies of Tumour-produced Proteins.- 13 Fibrinogen and Fibrinogen-related Peptides in Cancer.- 14 Studies of Antithrombin Turnover.- 15 Nutritional Aspects of Plasma Protein Metabolic Studies: Protein-Energy Malnutrition.- 16 Nutritional Aspects of Plasma Protein Metabolic Studies: Long-term Treatment of Chronic Uraemia by a Very-low-protein Diet Supplemented with Essential Amino Acids and Keto Analogues.- 17 Kinetics of Apolipoproteins A-I and A-II.- 18 The Plasma Apolipoproteins: Physiological Properties and Possible Role in Lipid Disorders and Atherogenesis.- 19 Role of Cell-Surface Receptors in the Behaviour in vivo of Transferrin.