Pathophysiology: The Biologic Basis for Disease in Adults and Children / Edition 8

by Kathryn L. McCance MS, PhD, Sue E. Huether MS, PhD

Overview

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 8th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW chapter on obesity and nutritional disorders, along with expanded coverage of rare diseases and epigenetics. It’s the most comprehensive and authoritative pathophysiology text available!

• The most comprehensive and authoritative pathophysiology text on the market provides unparalleled coverage of Pathophysiology content.
• Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text.
• Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment.
• Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content.
• Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition.
• Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes.
• Additional What’s New boxes highlight the most current research and clinical development.
• Nutrition and Disease boxes explain the link between concepts of health promotion and disease.
• Chapter summary reviews provide concise synopses of the main points of each chapter.

• NEW! Chapter on obesity and nutritional disorders thoroughly covers these growing global concerns.
• NEW! Added coverage of rare diseases and epigenetics further explore genetic disease traits.
• NEW! Over 50 new or heavily revised illustrations visually highlight pathophysiology concepts.
• NEW! More than 30 new 3D animations on Evolve bring difficult concepts to life for a new perspective on disease processes.

Product Details

ISBN-13:	9780323583473
Publisher:	Elsevier Health Sciences
Publication date:	02/14/2018
Edition description:	New Edition
Pages:	1720
Product dimensions:	8.70(w) x 11.10(h) x 2.50(d)

About the Author

Kathryn L. McCance, RN, PhD

Sue E. Huether, RN, PhD

Table of Contents

Part 1: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUES

Unit I: THE CELL

1. Cellular Biology

2. Altered Cellular and Tissue Biology: Environmental Agents

3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases

Unit II: GENES AND GENE-ENVIRONMENT INTERACTION

4. Genes and Genetic Diseases

5. Genes, Environment-Lifestyle, and Common Diseases

6. Epigenetics and Disease

Unit III: MECHANISMS OF SELF-DEFENSE

7. Innate Immunity: Inflammation

8. Adaptive Immunity

9. Alterations in Immunity and Inflammation

10. Infection

11. Stress and Disease

Unit IV. CELLULAR PROLIFERATION: CANCER

12. Cancer Biology

13. Cancer Epidemiology

14. Cancer in Children

Part 2: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS

Unit V: THE NEUROLOGIC SYSTEM

15. Structure and Function of the Neurologic System

16. Pain, Temperature Regulation, Sleep, and Sensory Function

17. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function

18. Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction

19. Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

20. Alterations of Neurologic Function in Children

Unit VI: THE ENDOCRINE SYSTEM

21. Mechanisms of Hormonal Regulation

22. Alterations of Hormonal Regulation

23. Obesity and Disorders of Nutrition NEW

Unit VII: THE REPRODUCTIVE SYSTEMS

24. Structure and Function of the Reproductive Systems

25. Alterations of the Female Reproductive System

26. Alterations of the Male Reproductive System

27. Sexually Transmitted Infections

Unit VIII: THE HEMATOLOGIC SYSTEM

28. Structure and Function of the Hematologic System

29. Alterations of Erythrocyte, Platelet, and Hemostatic Function

30. Alterations of Leukocyte and Lymphoid Function

31. Alterations of Hematologic Function in Children

Unit IX: THE CARDIOVASCULAR AND LYMPHATIC SYSTEMS

32. Structure and Function of the Cardiovascular and Lymphatic Systems

33. Alterations of Cardiovascular Function

34. Alterations of Cardiovascular Function in Children

Unit X: THE PULMONARY SYSTEM

35. Structure and Function of the Pulmonary System

36. Alterations of Pulmonary Function

37. Alterations of Pulmonary Function in Children

Unit XI: THE RENAL AND UROLOGIC SYSTEMS

38. Structure and Function of the Renal and Urologic Systems

39. Alterations of Renal and Urinary Function

40. Alterations of Renal and Urinary Tract Function in Children

Unit XII: THE DIGESTIVE SYSTEM

41. Structure and Function of the Digestive System

42. Alterations of Digestive Function

43. Alterations of Digestive Function in Children

Unit XIII: THE MUSCULOSKELETAL SYSTEM

44. Structure and Function of the Musculoskeletal System

45. Alterations of Musculoskeletal Function

46. Alterations of Musculoskeletal Function in Children

Unit XIV: THE INTEGUMENTARY SYSTEM

47. Structure, Function, and Disorders of the Integument

48. Alterations of the Integument in Children

Unit XV: MULTIPLE INTERACTING SYSTEMS

49. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

50. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children

What People are Saying About This

From the Publisher

Nowhere else will you find such comprehensive pathophysiology coverage of disease physiology

Editorial Reviews

Reviewer: Kevin J Watson, BA, RRT (William Beaumont Hospitals)
Description: This sixth edition of a pathophysiology textbook includes more than 300 new full-color illustrations and photographs as well as major revisions, updated content, and reorganized data in many of the chapters. New information is provided on esophagitis and esophageal reflux, inherited disorders of the renal system, neuroregulation of hormone responses and hormonal immune system interaction, pain modulation, chronic pain syndromes, and classification of sleep disorders.
Purpose: The authors explore the ways in which the various cells, tissues, and organs suffer within the human body, providing a comprehensive overview of pathophysiology. The authors hope readers will realize that the conceptual models used in the book relate not only to the suffering of cells, tissues, and organ systems but also of human beings — there is a person on the receiving end of all that suffering or pathology. The revisions in this edition make it a valuable and comprehensive resource.
Audience: Although not specifically stated, the book is designed for college-level healthcare programs, but anyone interested in the pathophysiology of the human body would benefit from reading this well-written and logically organized book.
Features: The book is organized into two parts. Part one covers the central concepts of pathophysiology of cells and tissues or the cellular environment. The 13 chapters in this part cover cellular biology, altered cellular and tissue biology, the cellular environment, genes and genetic diseases, immunity, infection and cancer. Part two deals with the suffering or pathophysiology within each organ system and the interaction that can occur with multiple organ system failure. Each organ system is easily identifiable by the index color coding at the top of the fore edge of the page. There are 11 units in this part, made up of chapters 14-46. Each organ system discussion includes the male and female anatomy of the system if there are differences, alterations in those systems, and alterations specific for children. The book includes numerous full color artist conceptions, color and black-and-white photographs, tables, figures, a 22-page glossary and hypertext links to online resources. The online resource provides a more comprehensive glossary and multimedia content.
Assessment: This updated edition is well written and logically organized and can go toe-to-toe with any other pathophysiology textbook. This is an excellent choice for healthcare students and would provide a worthy resource for public, college, and university libraries as well.

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