Oxidative Stress: Its Mechanisms and Impacts on Human Health and Disease Onset

by Harold Zeliger

Overview

Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation. Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset.

With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.

• Covers the chemical exposures and environmental factors that cause oxidative stress
• Provides further understanding on the mechanisms of oxidative damage response and disease
• Shows how oxidative stress and its role can be determined non-invasively via the Oxidative Stress Index

Product Details

ISBN-13:	9780323914581
Publisher:	Elsevier Science
Publication date:	10/23/2022
Sold by:	Barnes & Noble
Format:	eBook
Pages:	500
File size:	26 MB
Note:	This product may take a few minutes to download.

About the Author

Dr. Harold I. Zeliger holds a PhD in organic chemistry and has been a professor of chemistry and environmental science. He is a Certified Professional Chemist, a Board- Certified Forensic Examiner, and an EPA Certified Laboratory Director. Dr. Zeliger is the author of 51 technical publications, including basic research journal articles and patents. In his more than 40 years in the Chemical Process Industry, he has personally developed many industrial and consumer chemical products, designed chemical product warning labels and written Material Safety Data Sheets for toxic and flammable chemicals. Dr. Zeliger has investigated hundreds of toxic chemical exposures, environmental spills and discharges, chemical fires and explosions nationally and internationally. He has served repeatedly as an expert witness for both plaintiffs and defendants in chemical product, process, toxic exposure, environmental, flammable, intellectual property and subrogation claims. Dr. Zeliger has provided services for numerous forensic examinations, technology transfer and due diligence investigations. Dr. Zeliger’s research is in the area of chemical toxicology. His published work includes papers on the toxic effects of chemical mixtures and chemical causes of cancer clusters and two editions of Human Toxicology of Chemical Mixtures, Second Edition.

Table of Contents

I. Oxidative Stress and Disease 1. Oxidative stress causes 2. Historical perspective 3. Chemicals and chemical mixtures 4. Particles and fibers 5. Air pollution 6. Alcohol, tobacco and recreational drug use 7. Radiation 8. Chronic inflammation 9. Chronic Trauma 10. Dietary choices 11. Sleep deprivation 12. Hot and cold Environmental temperature extremes 13. Pre-existing disease 14. Pharmaceutical drugs 15. Chronic psychological stress 16. Genetic and epigenetic factors

II. Mechanism of Disease Onset 17. Disease hallmarks and biomarkers 18. Disease clusters 19. Disease co-morbidities 20. Free radical attack on DA 21. Free radical attack on proteins 22. Free radical attack on lipophilic cell membranes 23. Free radical stability factors 24. Free radical attack on mitochondria and energy production 25. Immune System role 26. Obesity-oxidative stress-disease triangle: Impact of obesity oxidative stress and disease 27. Acute versus chronic oxidative stress 28. Age and late onset disease 29. Total oxidative stress

III. Oxidative Stress Index and Its Applications 30. Oxidative stress index and its premise 31. Predicting likelihood of disease onset 32. Identifying primary causes of specific diseases 33. Oxidative Stress Index as a public health survey instrument 34. Adverse drug reaction prediction 35. Predicting severity of COVID-19 and other diseases 36. Oxidative Stress Index as a virtual diagnostic tool 37. Disease prevention 38. Future applications

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From the Publisher

Covers oxidative stress and its implications in human disease, describing mechanisms of disease induction and how the Oxidative Stress Index is used

Editorial Reviews

Reviewer: John T. Pierce, MBBS (MD) PhD(Navy Environmental Health Center)
Description: This descriptively titled book reviews the importance of oxidative stress and its role in health and disease.
Purpose: The purpose of the book is to examine the importance and environmental consequences of oxidative stress to a great extent.
Audience: The book will be useful to the forensic toxicology community and related fields.
Features: The book is subdivided into four sections: introducing the causes of oxidative stress, molecular mechanisms underlining its importance, disease onset prediction, and a view toward the prevention of oxidative stress.
Assessment: This book is extensively referenced and will serve as a useful summary of oxidative stress.

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