Oxidation: The Cornerstone of Carcinogenesis: Oxidation and Tobacco Smoke Carcinogenesis. A Relationship Between Cause and Effect / Edition 1

by John C. Stavridis

Overview

In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.

Product Details

ISBN-13:	9789048177028
Publisher:	Springer Netherlands
Publication date:	11/19/2010
Edition description:	Softcover reprint of hardcover 1st ed. 2008
Pages:	258
Product dimensions:	6.10(w) x 9.25(h) x 0.24(d)

About the Author

John C. Stavridis is a medical doctor who studied Medicine at the Military Medical School of Thessaloniki, Greece. He specialized in Internal Medicine at the Evangelismos Medical Centre, Athens, and received his MD and Professorship from the University of Athens Medical School. Following a postdoctoral position as a senior research fellow and registrar at postgraduate Medical School, London University, Hammersmith Hospital, Department of Clinical Hematology, he joined the Hematology Unit at St. Sabbas Anticancer Hospital, Athens, as director. He taught Physiology from 1991-1999 as a head of the Department of Physiology and full professor at the University of Athens Medical School. Since 1999, Prof. Stavridis has been President of the Institute of Biomedical Research and Biotechnology, Athens.

Table of Contents

Oxygen and Nitrogen Free Radicals.- Oxidative Stress.- Oxidative Damage of Genome DNA: Repair Mechanisms.- Mihondria: Structure, Function and Relationship with Carcinogenesis.- Oxidative Activation of Transcription Factor Pathways by Cigarette Smoke Oxidants.- Cell Protection Mechanisms from Oxidation.- Role of DNA Adducts in Carcinogenesis.- Transmolecular Reactions of Genetic Toxicity: Alkylation and Methylation of DNA.- Toxicity and Carcinogenicity of Hydrocarbons.- Toxicity and Carcinogenicity of the Aromatic Hydrocarbons.- Toxicity and Carcinogenicity of Aldehydes.- Toxicity and Carcinogenicity of the Nitriles.- Toxicity and Carcinogenicity of the Eterocyclic Organic Compounds.- Toxicity and Carcinogenicity of Metals.- Oxidative Profile of Cigarette Smoke and Lung Cancer.- Smoking and Lung Cancer.

Editorial Reviews

"The book "Oxidation: The Cornerstone of Carcinogenesis" by Professor J. C. Stavridis represents a monumental work of correlating oxidation as the common pathway of causing cell damage to the bronchoepithelial cells and carcinogenesis utilized by the various tobacco smoke constituents. ...

This book by Prof. Stavridis is a significant intellectual feat of the first order, bringing original insights and a comprehensive review of an area that heretofore had been unaccountably neglected." (Dr. Constantine Karakousis, Professor of Surgical Oncology)

"In the first page of the book the author states: "It is important to understand the properties of dioxygen since oxidation reactions using it power not only our bodies but our entire civilization"....

Written by an expert, this book does not merely address an emerging topic, but additionally it fills a void by analytically and expansively linking oxidation and carcinogenesis and providing knowledge and information to researchers and other stakeholders of scientific knowledge. I welcome the insights presented in the book and intend to include it among the reference books I provide to my students of risk assessment and management." (Dr. Demetrios J. Moschandreas, Professor of Environmental Engineering)

From the Publisher