Organelle and Molecular Targeting
510Organelle and Molecular Targeting
510Paperback
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Overview
The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.
Product Details
ISBN-13: | 9780367552831 |
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Publisher: | CRC Press |
Publication date: | 08/26/2024 |
Pages: | 510 |
Product dimensions: | 7.00(w) x 10.00(h) x (d) |
About the Author
Dr. Mansoor M. Amiji is the University Distinguished Professor, Professor of Pharmaceutical Sciences, and Professor of Chemical Engineering at Northeastern University in Boston, MA. His primary areas of research interest are in the development of targeted therapeutic solutions for chronic diseases such as cancer, neurodegenerative diseases, and inflammatory diseases. Dr. Amiji has edited 10 books including Applied Physical Pharmacy (now in 3rd edition), Nanotechnology for Cancer Therapy (Taylor & Francis, 2007), Handbook of Materials for Nanomedicine (Pan Stanford Publishing, 2010), and Diagnostic and Therapeutic Applications of Exosomes in Cancer (Elsevier, 2018) along with over 70 published book chapters, and over 360 peer-reviewed articles.