Table of Contents
Preface v
Contributors xi
1 Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eye J. William Harbour 1
2 Clinical Overview: Retinoblastoma Jerry A. Shields Carol L. Shields 19
3 Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elements Marie Diener-West Claudia Scala Moy 35
4 Epidemiology of Retinoblastoma James J. Augsburger 47
5 Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis Karen Sisley Ian G. Rennie 63
6 Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanoma Paul R. van Ginkel 81
7 A Cascade of Genomic Changes Leads to Retinoblastoma Vivette D. Brown Helen S. L. Chan Brenda L. Gallie 103
8 The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastoma Kurtis R. Van Quill Joan M. O'Brien 129
9 Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells In Vitro Dan-Ning Hu Steven A. McCormick 189
10 p53 and the Molecular Regulation of Cell Fate in Retinoblastoma Robert W. Nickells Cassandra L. Schlamp 211
11 Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy Jacobus J. Bosch Bruce R. Ksander 231
12 Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy Jerry Y. Niederkorn 255
13 Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanoma Stefan Dithmar Hans E. Grossniklaus 269
14 Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues Daniel M. Albert Robert W. Nickells Soesiawati R. Darjatmoko Isabelle Audo 297
15 Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatment Dan S. Gombos William F. Mieler 321
16 The Treatment of Retinoblastoma David H. Abramson Amy C. Schefler 353
17 Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumors Timothy G. Murray H. Culver Boldt Brandy Hayden Claudia Scala Moy 377
18 Clinical Trials in Retinoblastoma Emily Y. Chew 401
19 Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosis Robert Folberg Jacob Pe'er 407
20 Retinoblastoma: Pathology and Prognosis Ian W. McLean 427
21 Molecular Genetics of Retinoblastoma Isabelle Audo José Sahel 449
22 Genetically Engineered Mouse Models of Retinoblastoma Jolene J. Windle Daniel M. Albert 465
23 Treatment of Extraocular Retinoblastoma Diane Puccetti 489
Index 499
