Nutrition and Biotechnology in Heart Disease and Cancer

by John B. Longenecker (Editor), David Kritchevsky (Editor), Marc K. Drezner (Editor)

Overview

There is a unique nutritional commonality developing in research relating to coronary heart disease and cancer. The primary aim of this conference was to provide a forum for the leading researchers, clinicians, educators and administrators in these two fields to present a program on heart disease and cancer which included a) the major historical milestones, b) the present areas of greatest interest in research and therapy, c) the latest nutritional, molecular, and biotechnological advances, and d) a perspective on the most promising areas for future research and therapy. Scientists have long contended that research marches on the feet of methodology. Thus there are numerous examples of research fields opening secondary to methodological advances. Some examples are: 1) thin layer and gas-liquid chromatography which, along with high pressure liquid chromatography have broadened the line of advances in lipid research and 2) peR and the resultant impact on molecular biological approaches to several fields of science. The organizers of this conference thought the time was propitious for bringing together knowledge on newer aspects of molecular biological research with current advances in the two major areas of degenerative disease—coronary heart disease and cancer. Our knowledge of these "killer diseases" has expanded greatly in the past few years and the advance has been catalyzed by use of an array of molecular biological techniques. Thanks to these, medical thinking in these areas is changing from considerations of treatment to strategies for prevention.

Product Details

ISBN-13:	9781461358046
Publisher:	Springer US
Publication date:	06/14/2012
Series:	Advances in Experimental Medicine and Biology , #369
Edition description:	Softcover reprint of the original 1st ed. 1995
Pages:	267
Product dimensions:	7.01(w) x 10.00(h) x 0.02(d)

About the Author

Longenecker, John B. (Univ of North Carolina at Chapel Hill); Kritchevsky, David (Wistar Institute of Anatomy and Biology); Drezner, Marc K. (Duke Univ)

Table of Contents

Heart Disease.- Historical Review of Research on Atherosclerosis.- Nutrition and Coronary Heart Disease Epidemiology.- Obesity, Fat Patterning and Cardiovascular Risk.- The Role of Lipoproteins in Atherogenesis.- Role of Oxidized LDL and Antioxidants in Atherosclerosis.- Signal Transduction in Atherosclerosis: Second Messengers and Regulation of Cellular Cholesterol Trafficking.- Genetic Determinants of Myocardial Infarction.- Gene Therapy in Heart Disease.- Possible Role of Viruses in Atherosclerosis.- Impact of Biotechnology in the Diagnostic and Therapeutic Management of Cardiovascular Disorders.- Cancer.- Nutrition and Carcinogenesis: Historical Highlights and Future Prospects.- Epidemiology of Anticarcinogens in Food.- Dietary Effects on DNA Methylation: Do They Account for the Hepaarcinogenic Properties of Lipotrope Deficient Diets?.- Cholesterol, Cholesterogenesis and Cancer.- Inhibition of the Induction of Cancer by Antioxidants.- Nutrients, Signal Transduction and Carcinogenesis.- Nutrition, Immunology and Cancer: An Overview.- Anemia of Malignancy.- Heart Disease and Cancer.- Diet in Heart Disease and Cancer.- Carcinogens in Foods: Heterocyclic Amines and Cancer and Heart Disease.- Genetic Engineering of Foods to Reduce the Risk of Heart Disease and Cancer.- NIH Initiative.- New Directions in Dietary Studies in Cancer: The National Cancer Institute.- New Directions in Dietary Studies and Heart Disease; The National Heart, Lung and Blood Institute Sponsored Multicenter Study of Diet Effects on Lipoproteins and Thrombogenic Activity.- Abstracts of Poster Sessions.

Editorial Reviews

3 Stars from Doody

This book presents the proceedings of a conference on Nutrition and Biotechnology in Heart Disease and Cancer held in December 1993. The book is divided into four sections devoted to heart disease, cancer, heart disease, and cancer and NIH initiatives. The book contains several valuable chapters reviewing the history of studies of nutrition in heart disease and cancer. These chapters are followed by descriptions of the role of dietary and endogenous fats in the development of heart and vascular disease and of recent genetic and molecular information discovered about heart disease. The cancer section reviews the relationship between nutrition and cancer and several putative molecular mechanisms of carcinogenesis. The third section discusses commonalities in role of nutrition toward development of heart disease and cancer. The purpose is to explore the commonality of nutrition in the development of heart and vascular disease and cancer. The forum from which this book derives sought to bring together presentations of greatest interest in research and therapy involving nutrition, molecular, and biotechnical advances along with a perspective on the most promising areas of future research in these fields. The audience this book is aimed at include leading researchers, administrators, students, and clinicians in the fields of heart and vascular disease, cancer, and nutrition. The book features a wide variety of views concerning the role of nutrition in development of heart disease and cancer. Understanding of these relationships at multiple levels is presented. This book reviews the current state of knowledge relating nutrition and heart disease and cancer. It presents several lines of evidencethat nutritional status has direct influence on heart disease and cancer. Suggested future directions are valuable to investigators, clinicians, and students. However, this is book ignores several additional biotechnologies that may yield valuable therapies as well as understanding of the biology of cancer and heart disease, such as PCR, transgenic animals, and antisense technology. Chapters describing many of the new molecular techniques and approaches would ably reinforce the goals of this book. One glaring omission is the lack of chapters exploring the ingestion of alcohol and tobacco and the generation of heart and vascular disease and cancer. Chapters discussing the epidemiology and molecular mechanistic links between these forms of nutrition and these two, expensive, ^^killer^^ diseases, especially in the light of Mickey Mantle's recent death, would have made this book highly relevant.

Roy D. Goldfarb

Proceedings of the December 1993 title conference held in Research Triangle Park, North Carolina, presenting research on nutritional factors in coronary heart disease and cancer. Topics include the role of lipoproteins in atherogenesis, the impact of biotechnology in diagnosis and therapeutic management of cardiovascular disorders, epidemiology of anticarcinogens in food, and heterocyclic amines in foods. Includes an overview, and material on genetic engineering of foods to reduce cancer and heart disease risk. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Roy D. Goldfarb, PhD (Rush University Medical Center)
Description: This book presents the proceedings of a conference on Nutrition and Biotechnology in Heart Disease and Cancer held in December 1993. The book is divided into four sections devoted to heart disease, cancer, heart disease, and cancer and NIH initiatives. The book contains several valuable chapters reviewing the history of studies of nutrition in heart disease and cancer. These chapters are followed by descriptions of the role of dietary and endogenous fats in the development of heart and vascular disease and of recent genetic and molecular information discovered about heart disease. The cancer section reviews the relationship between nutrition and cancer and several putative molecular mechanisms of carcinogenesis. The third section discusses commonalities in role of nutrition toward development of heart disease and cancer.
Purpose: The purpose is to explore the commonality of nutrition in the development of heart and vascular disease and cancer. The forum from which this book derives sought to bring together presentations of greatest interest in research and therapy involving nutrition, molecular, and biotechnical advances along with a perspective on the most promising areas of future research in these fields.
Audience: The audience this book is aimed at include leading researchers, administrators, students, and clinicians in the fields of heart and vascular disease, cancer, and nutrition.
Features: The book features a wide variety of views concerning the role of nutrition in development of heart disease and cancer. Understanding of these relationships at multiple levels is presented.
Assessment: This book reviews the current state of knowledge relating nutrition and heart disease and cancer. It presents several lines of evidence that nutritional status has direct influence on heart disease and cancer. Suggested future directions are valuable to investigators, clinicians, and students. However, this is book ignores several additional biotechnologies that may yield valuable therapies as well as understanding of the biology of cancer and heart disease, such as PCR, transgenic animals, and antisense technology. Chapters describing many of the new molecular techniques and approaches would ably reinforce the goals of this book. One glaring omission is the lack of chapters exploring the ingestion of alcohol and tobacco and the generation of heart and vascular disease and cancer. Chapters discussing the epidemiology and molecular mechanistic links between these forms of nutrition and these two, expensive, "killer" diseases, especially in the light of Mickey Mantle's recent death, would have made this book highly relevant.

Doody's Review Service