Normal And Malignant Hematopoiesis: New Advances

by Enrico Mihich (Editor), Eliza Hall (Editor), Donald Metcalf (Editor)

Overview

''An exciting glance at key issues in contemporary hematopoiesis.'' -The Quarterly Review of Biology

Product Details

ISBN-13:	9780306451362
Publisher:	Springer-Verlag New York, LLC
Publication date:	10/28/1995
Series:	Pezcoller Foundation Symposia Series , #6
Edition description:	New Edition
Pages:	249
Product dimensions:	6.64(w) x 10.16(h) x 0.76(d)

About the Author

Mihich, Enrico (Roswell Park Cancer Institute); Metcalf, Donald (Royal Melbourne Hospital)

The contributors were participants in the Sixth Pezcoller Symposium on Normal and Malignant Hematopoiesis: New Advances held in July 1994 in Rovereto, Italy.

Table of Contents

Regulation of Normal Hemopoiesis; D. Metcalf. Cytokine Regulation of Lymphohemopoietic Progenitors; M. Ogawa, F. Hirayama. Hematopoietic Stem Cells; I. Weissman. Transcriptional Control of Hematopoietic Development: Roles of GATA-Factors; S.H. Orkin, et al. Rearrangement of the ALL-1 Gene in Acute Myeloid Leukemia without Chromosomal Translocations; S.A. Schichman, C.M. Croce. Nonreceptor Protein Tyrosine Kinases: Pivotal Regulatory Molecules Controlling Lymphopoiesis; R.M. Perlmutter, et al. The Regulation and Function of p21Ras in T Cell Activation and Growth; D.A. Cantrell, et al. Irf-1 Functions as a Tumor Suppressor: Possible Involvement in Human Myelodysplasia and Leukemia; T. Taniguchi, et al. A Family of High Molecular Weight Proteins Active in Differentiation and Growth Control; R.E. Eckner, et al. Hematopoietic Signaling by the Cytokine Receptor Superfamily; J.N. Ihle. Positive and Negative Growth Effects of Abl Genes; C.L. Sawyers, et al. Advances in the Understanding of the Molecular Pathogenesis of Aggressive B Cell Lymphomas; K. Cechova, et al. Structure and Expression Pattern of the PML Gene; M. Fagioli, P.G. Pelicci. 5 additional articles. Index.

Editorial Reviews

Within the framework of comparing normal and leukemic hematopoiesis, considers the genetic basis of the regulation of hematopoiesis and its molecular mechanisms: the function of such genes as ALL1, RAS, Abl, PML, and Cyclin D; the mechanisms of transcriptional control; the pathways of signal transduction; the role of certain cytokines; the involvement of growth versus differentiation; and approaches to cancer treatment based on the stimulation of differentiation with retinoids and the modulation of certain cytokines. The 18 papers comprise the proceedings of a symposium in Rovereto, Italy, June to July 1994. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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