New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
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New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
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New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
195
New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
195
109.99
In Stock
Product Details
| ISBN-13: | 9783319007014 |
|---|---|
| Publisher: | Springer International Publishing |
| Publication date: | 08/11/2013 |
| Series: | Springer Theses |
| Edition description: | 2013 |
| Pages: | 195 |
| Product dimensions: | 6.10(w) x 9.25(h) x 0.02(d) |
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