Neuroprotective Signal Transduction / Edition 1

by Mark P. Mattson

Overview

In Neuroprotective Signal Transduction prominent researchers and clinicians focus on how inter- and intracellular signaling mechanisms prevent the degeneration and death of neurons occurring in both acute and chronic neurodegenerative disorders. Authoritative contributions dissect the signaling pathways of an array of neuroprotective factors-ranging from neurotrophins (NGF, BDNF, NT-3, and NT-4/5), to growth factors (bFGF, IGF-1, GDNF), to cytokines (TNF, IL-1b, and TGFb), to secreted amyloid precursor proteins, to protease nexin-1. Also treated are cytoprotective signaling events that occur within injured neurons independently of intercellular signals. Neuroprotective Signal Transduction presents fundamental, cutting-edge treatment of the cellular and molecular signal transduction pathways found in human neurodegenerative conditions. The book's elucidation of the molecular cascades evolved by the nervous system to protect itself is now lead to effective strategies for preventing neuronal degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, and will form the basis for powerful new drug discovery and gene therapy strategies.

Product Details

ISBN-13:	9780896034730
Publisher:	Springer-Verlag New York, LLC
Publication date:	10/10/1997
Series:	Contemporary Neuroscience
Edition description:	1998
Pages:	347
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

About the Author

Mattson, Mark P. (Univ of Kentucky)

The contributors represent the specialties of internal medicine, anatomy, neurobiology, molecular biology, pharmacology, and neurology. Most are from universities in the U.S., including Univ of Kentucky, Oregon Health Sciences Univ, Washington Univ, and Stanford.

Table of Contents

Neuroprotective Strategies Involving the Neurotrophins and Their Signaling Pathways.- Nerve Growth Factor and Its Receptors in the Primate Forebrain.- Molecular Mechanisms of Neuroprotection from Neuronal Death by Trophic Factor Deprivation.- Gene Induction and Neuronal Apoptosis.- Clinical Potential of Compounds That Stimulate Nerve Growth Factor Production.- Preclinical Trials of Basic Fibroblast Growth Factor (bFGF) in Animal Models of Stroke.- Transforming Growth Factor-β Signaling and Neuroprotection.- Protective and Regenerative Properties of GDNF in the Central Nervous System.- Tumor Necrosis Factor.- Neuroprotective Strategies Based on Interleukin Signaling.- Signaling by—-Amyloid Precursor Protein.- Clinical Potential of Agents That Affect Thrombin Signaling in Degenerative and Traumatic Neurologic Disorders.- Thrombin and Thrombin Inhibitors.- Deleterious and Salutary Effects of Steroid Hormones in the Nervous System.- Therapeutic Potential of Leukocyte Antiadhesion Strategies in CNS Ischemia.- Neuroprotective Strategies Based on Targeting of Postreceptor Signaling Events.

Editorial Reviews

Researchers and clinicians explore the signaling pathways of an array of neuroprotective factors, including neurotrophins, growth factors, cytokines, secreted amyloid precursor proteins, and protease nexin-1. They also treat cytoprotective signal events that occur with injured neurons independently of intercellular signals. The information on the molecular cascades evolved by the nervous system to protect itself furthers drug discovery; gene therapy strategies; and strategies for preventing neuron degeneration in such conditions as stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Annotation c. by Book News, Inc., Portland, Or.

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