Neuropeptides in Respiratory Medicine

by Michael A. Kaliner (Editor), Peter J. Barnes (Editor), Gert H.H. Kunkel (Editor), James N. Baraniuk (Editor)

Overview

""This outstanding resource offers comprehensive presentations of the latest basic knowledge and the most advanced research on neuropeptides of the respiratory tract covering the structure, receptors, molecular biology, and function of each important neuropeptide and examining how they relate to disease. Demonstrates the utility of immunohistochemistry, autoradiography, molecular biology, smooth muscle contraction, and glandular secretion for the study of neural function both in vitro and in vivo!

Product Details

ISBN-13:	9781351428866
Publisher:	CRC Press
Publication date:	09/29/2017
Series:	Clinical Allergy and Immunology
Sold by:	Barnes & Noble
Format:	eBook
Pages:	720
File size:	7 MB

About the Author

PeterJ. Barnes

Table of Contents

Part 1 Innervation of the Airways: Neuropeptides and Classic Innervation - Neural Structures in Human Airways; Functional Autonomic Innervation of the Airways - The Cholinergic and Adrenergic Systems; Neuropeptides in the Lower Airways Investigated by Modem Microscopy; Neural Control of the Upper Respiratory Tract; Peptide Biosynthesis and Secretion - Some Recent Developments and Unresolved Issues; Vasoactive Intestinal Polypeptide in the Respiratory Tract; Neuropeptide Y in the Airways; Sensory Nerves and Tachykinins; Pulmonary Endocrine Cells In Vivo and In Vitro; Molecular Characterization of Autonomic and Neuropeptide Receptors; Autonomic Receptors in the Upper and Lower Airways; Tachykinin Receptor Antagonists; Pulmonary Peptidases - General Principles of Peptide Metabolism and Molecular Biology of Angiotensin Converting Enzyme, Neutral Endopeptidase 24.11, and Carboxypeptidase M; Peptidases in the Respiratory Tract - The Localization and Actions of Carboxypeptidase M. Part 2 Physiological Functions of Neuropeptides in the Airways: The Concept of Neurogenic Inflammation in the Respiratory Tract; Modulation of Neurogenic Inflammation by Peptidase; Control of Airway Vascular Beds; Basophil and Mast Cell Activation - Neuropeptides and Nerves; Inositol Triphosphate and Smooth Muscle Function; Neuropeptides and Airway Macromolecule Secretion; ATP as Neurally Released Modulator of Human Airway Ion Transport; Effects of Neuropeptides on Neurotransmission in the Airways. Part 3 Pathophysiological Contribution of Neuropeptides to Disease: Neuropeptides and Asthma; Inflammatory Mechanisms in Cystic Fibrosis Lung Disease; Allergic Rhinitis; Neuropeptides in Small Cell Lung Carcinoma; Neuroregulation of Pulmonary Immunity - The Roles of Substance P and Vasoactive Intestinal Peptide; Sensory Neuropeptides in an Animal Model of Hyperpnoea-induced Bronchoconstriction; Nitric Oxide and Guanylyl Cyclases - Correlation with Neuropeptides; Neuropeptides in Bronchoalveolar Lavage in Allergic Asthma; Morphology of Neurogenic lnflammation in the Airways - Plasma Protein Movement Across the Airway Mucosa and Epithelium.

Editorial Reviews

3 Stars from Doody

This is the fourth in the series Clinical Immunology and Allergy. This volume focuses on neuropeptides in respiratory medicine. The purpose is to cover the basic biology of neuropeptides, physiologic functions of neuropeptides, and their contribution to disease. It is based on a meeting concerned with neuropeptides. The book is useful and meets the objectives of the authors. The audience is basic and clinical scientists interested in respiratory medicine, neuropeptides, and mechanisms of respiratory diseases. Thirty one chapters cover innervation of the airways, physiological function of neuropeptides in the airways, and the pathophysiological contribution of neuropeptides to disease. The references are current and pertinent. It is obvious that the sciences involved in various aspects of neuropeptides are moving rapidly in the accumulation of basic knowledge and the application of this knowledge to disease states and to modification of these disease states in the future. This book applies this approach to respiratory medicine. It is a valuable contribution to basic or clinical scientists dealing with respiratory mechanisms, innervation, or various respiratory diseases.

Roy Patterson

Based on a conference held in Pottsdam, Germany in May 1993, this comprehensive volume for both clinicians and scientists deals first with the basic biology of neuropeptides in general and then discusses the most interesting of the neuropeptides, one by one. Neuropeptide receptors and antagonists are discussed, especially as they may apply to clinical medicine, as are the enzymes involved in metabolizing neuropeptides. Finally, there are a series of chapters on the various diseases in which neuropeptides may play a role. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Roy Patterson, MD (Northwestern University Feinberg School of Medicine)
Description: This is the fourth in the series Clinical Immunology and Allergy. This volume focuses on neuropeptides in respiratory medicine.
Purpose: The purpose is to cover the basic biology of neuropeptides, physiologic functions of neuropeptides, and their contribution to disease. It is based on a meeting concerned with neuropeptides. The book is useful and meets the objectives of the authors.
Audience: The audience is basic and clinical scientists interested in respiratory medicine, neuropeptides, and mechanisms of respiratory diseases.
Features: Thirty one chapters cover innervation of the airways, physiological function of neuropeptides in the airways, and the pathophysiological contribution of neuropeptides to disease. The references are current and pertinent.
Assessment: It is obvious that the sciences involved in various aspects of neuropeptides are moving rapidly in the accumulation of basic knowledge and the application of this knowledge to disease states and to modification of these disease states in the future. This book applies this approach to respiratory medicine. It is a valuable contribution to basic or clinical scientists dealing with respiratory mechanisms, innervation, or various respiratory diseases.

Doody's Review Service