Neurobiology of Disease

by Sid Gilman (Editor)

Overview

Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields. - Provides cutting edge information about fundamental mechanisms underlying neurological diseases - Amply supplied with tables, illustrations and references - Includes supporting clinical information putting the mechanisms of disease into perspective

Product Details

ISBN-13:	9780080466385
Publisher:	Elsevier Science & Technology Books
Publication date:	09/06/2011
Sold by:	Barnes & Noble
Format:	eBook
Pages:	1104
File size:	38 MB
Note:	This product may take a few minutes to download.

Table of Contents

Part I. Central Nervous SystemSection A. Metabolic Diseases – Hugo W. MoserChapter 1: LeukodystrophiesChapter 2: Lysosomal Disorders of the Nervous SystemChapter 3: The Neurobiology of Peroxisomal DisordersChapter 4: Creatine Deficiency SyndromesSection B. Neurodegenerative Disorders – Gregor Wenning Chapter 5: Parkinson's DiseaseChapter 6: Alzheimer DiseaseChapter 7: Multiple System AtrophyChapter 8: Olivopontocerebellar Atrophy (OPCA)Chapter 9: Neurobiology of Progressive Supranuclear PalsySection C. Genetic Diseases – Christopher Gomez Chapter 10: Protein Aggregation DisordersChapter 11: RNA-Based Disorders of Muscle and BrainChapter 12: Ion Channel DisordersChapter 13: Spinocerebellar Ataxia Type 1Chapter 14: Shared Transcriptional Consequences of Mitochondrial Disease, Ischemic Hypoxia and Chemical HypoxiaSection D. Neuroimmunological Disorders – Anthony T. Reder Chapter 15: Paraneoplastic Neurological DisordersChapter 16: Systemic Lupus Erythematosus: Descriptive Past and Mechanistic FutureChapter 17: Progressive Multifocal LeukoencephalopathyChapter 18: Multiple SclerosisChapter 19: Immune-Mediated NeuropathiesChapter 20: Hashimoto EncephalopathySection E. Cerebrovascular Diseases – Lewis MorgensternChapter 21: Vascular Cognitive ImpairmentChapter 22: CardioembolismChapter 23: Coagulation DisordersChapter 24: Clinical and Neurobiological Aspects of Stroke RecoveryChapter 25: Non-Atherosclerotic Cerebral VasculopathiesChapter 26: Subarachnoid HemorrhageChapter 27: Cerebral Ischemia: Molecular Mechanisms and Protective TherapiesChapter 28: Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain InjurySection F. Paroxysmal Disorders – Timothy A. Pedley Chapter 29: Idiopathic EpilepsiesChapter 30: Paroxysmal DyskinesiaChapter 31: Neurobiology of MyoclonusChapter 32: Channelopathies of the Nervous SystemChapter 33: MigraineChapter 34: Temporal Lobe EpilepsySection G. Neoplastic Diseases – John Laterra Chapter 35: CNS MetastasesRobert J. WeilChapter 36: MeningiomaKatrin Lamszus, Christian Hagel, and Manfred WestphalChapter 37: CNS LymphomaCorresponding Author: Dr. BatchelorChapter 38: Neurofibromatosis 1Linda Piersall and David H. GutmannChapter 39: Medulloblastoma and Primitive Neuroectodermal TumorsSaid Elshihabi and James T. RutkaChapter 40: GliomaAnders I. Persson, QiWen Fan, Joanna J. Phillips, and William A. WeissSection H. Infectious Diseases – Richard T. Johnson Chapter 41: Bacterial & FungalChapter 42: Parasitic InfectionsChapter 43: Prion DiseasesChapter 44: Central Nervous System Viral Infections: Clinical Aspects and Pathogenic MechanismsSection I. Motor Neuron Diseases – Eva L. Feldman Chapter 45: Spinal Muscular AtrophyChapter 46: Amyotrophic Lateral Sclerosis-Like Syndromes Associated with MalignancyChapter 47: Amyotrophic Lateral Sclerosis (ALS): Idiopathic and InheritedChapter 48: Hereditary Spastic Paraplegia and Primary Lateral SclerosisChapter 49: PoliomyelitisChapter 50: Spinobulbar Muscular Atrophy (Kennedy's Disease)Section J. Malformations and Developmental Disorders – Michael V. JohnstonChapter 51: Neurobiology of Genetic Mental RetardationChapter 52: Cerebral PalsyChapter 53: AutismChapter 54: Neurobiology of DyslexiaChapter 55: Neonatal Brain InjuriesChapter 56: Spina BifidaChapter 57: Circuits to Synapses: The Pathophysiology of Tourette SyndromeChapter 58: Attention Deficit Hyperactivity DisorderChapter 59: Congenital Hydrocephalus Section K. Neurologic Manifestations of Medical Diseases – John J. Caronna Chapter 60: Hematological DisordersChapter 61: Renal DiseaseChapter 62: Diabetes and Endocrine DisordersChapter 63: Mechanisms and Consequences of CNS HypoxiaChapter 64: Gastroenterologic and Hepatic Diseases and Their Effects on CNSChapter 65: SarcoidosisSection L.

What People are Saying About This

From the Publisher

The definitive reference on the neurobiology of disease, translating basic science into clinical practice.

Editorial Reviews

Reviewer: George F Wittenberg, M.D., Ph.D.(University of Maryland School of Medicine)
Description: This unique textbook, a selective review of neuropathophysiology for the neuroscientist, aims at presenting many neurological disorders along with the science underlying their etiology and treatment.
Purpose: The purpose of this book is to provide basic neuroscientists with a comprehensive view of the mechanisms underlying specific neurological diseases. This is not only a worthy objective, it is unfulfilled by any other book, to my knowledge. The objectives are met by the formula applied by the section editors. It does not cover everything, but it does cover all common disorders as well as those thought to be of particular interest.
Audience: The book is squarely aimed at neuroscience graduate students, and would also be a good source of clinical and pathophysiological information for a translational scientist. The editor, section editors, and contributors are all authorities in their fields.
Features: It starts off with lysosomal disorders, which is a little jarring, but the book is organized into central and peripheral disorders, with the central disorders subdivided mainly by disease etiologies (neoplastic, vascular, etc.) One section covers imaging methods, which is very helpful, given their importance in both clinical diagnosis and research. Peripheral disorders (nerve and muscle) receive somewhat short shrift, particularly as both central and peripheral pain syndromes are included in this half of the text. Cerebrovascular disease is well covered, including vascular dementia and recovery of function after stroke. Pediatric disorders are well covered, including developmental syndromes, and selected genetic and metabolic disorders. Multiple sclerosis gets a fairly short chapter, and leaves one with a sense of frustration about the disorder, which is probably appropriate. Color illustrations and other graphic elements in each chapter give the students a take-home message. Although the stated purpose limited topics to neurology, psychiatric disorders are not covered, with a few exceptions on the extensive border between psychiatry and neurology (e.g. attention-deficit hyperactivity).
Assessment: For five years I was course director of clinical neuroscience, a course for neuroscience program graduate students, the intent of which was to expose students to the broad range of clinical problems where gaps in knowledge limited clinical practice. This exposure provides clinical context for students who already have an intellectual interest. It also facilitates collaboration, and ultimately, translational research. The problem that I faced five years ago is that the only appropriate textbook that I new of, Pearlman and Collins's Neurobiology of Disease (Oxford University Press, 1989), was out of print. But even that book was more oriented toward the other direction of information flow, from neuroscience to clinicians. Now a book with the same name aims mainly at the target audience of neuroscientists. It has no competitors, to my knowledge, but could be supplemented by a similar text for psychiatric disorders.

Doody's Review Service

"I think [the book] is very valuable, and it has benefited from careful editing and good organization. ...The illustrations are excellent — color has been used judiciously and effectively. ...The number of undergraduate neuroscience majors is growing, and a book of this type could be of great value to them. Neurology residents would find it a very quick way to get the background on which to superimpose new findings. ...Overall, I think the book does achieve the goals that Gilman proposed — he and his colleagues are to be congratulated." —Guy McKhann, MD, Johns Hopkins University in the NEW ENGLAND JOURNAL OF MEDICINE, May 30, 2007

From the Publisher