Neocortical Grafting to Newborn and Adult Rats: Developmental, Anatomical and Functional Aspects / Edition 1

by Afsaneh Gaillard, Frederic Gaillard, Michel Roger

Overview

The first experiments with neural transplantation into the brain (for a review, see Bjorklund and Stenevi 1985) were reported at the end of the last century by Thompson (1890), who took cortical tissue from adult cats and implanted the tissue pieces into the neocortex of adult dogs. The neurons did not survive, but the transplanted mass did not disintegrate entirely. Successful graft­ ing into the brain was reported later by Ranson (1909), who implanted spinal ganglia into the cerebral cortex of developing rats, and by Dunn (1917), who reported survival of implanted neonatal cortex into the cortex of newborn recipients. Another important step was made by Le Gros Clark (1940) who reported that, in the rabbit, embryonic (E) cortical tissue could be successfully grafted into the cortex of young recipients. Ex­ periments by Wallace and Das (1982), and Bjorklund and Stenevi (1984), showing behavioral effects of grafts, subsequently stimu­ lated a growing interest in neurotransplantation research. Intrac­ erebral grafting is now considered a powerful tool for addressing fundamental questions about development, regenerative, or re­ storative phenomena in the central nervous system (CNS) and is a potential therapy for neurodegenerative diseases.

Product Details

ISBN-13:	9783540642527
Publisher:	Springer Berlin Heidelberg
Publication date:	07/01/1998
Series:	Advances in Anatomy, Embryology and Cell Biology , #148
Edition description:	Softcover reprint of the original 1st ed. 1998
Pages:	86
Product dimensions:	6.10(w) x 9.25(h) x 0.01(d)

About the Author

Gaillard, Afsaneh; Gaillard, Frederic; Roger, Michel

Table of Contents

1 Transplantation of Embryonic Cortex into Newborn Host Cortex: A Means to Study Neural Development.- 1.1 Introduction.- 1.2 Materials and Methods.- 1.3 Early Specification of Neocortical Efferent Projections: The Homo- or Heterotopic Transplantation Paradigm.- 1.4 Conclusion.- 2 Transplantation of Embryonic Cortex into the Damaged Cortex of Adult Rats.- 2.1 Introduction.- 2.2 Transplantation into the Frontal Cortex: Anatomical, Metabolic, and Behavioral Aspects.- 2.3 Transplantation into the Occipital Cortex: Electrophysiological and Anatomical Aspects.- 2.4 Conclusion.- 3 Summary.- 4 References.