Multidisciplinary Approaches to Cholinesterase Functions

by Avigdor Shafferman (Editor), B. Velan (Editor)

Overview

Molecular Polymorphism: Biosynthesis of the Molecular Forms of Acetylcholinesterase (J. Massoulie et al.). Molecular Organization of Recombinant Human Acetylcholinesterase (B. Velan et al.). Nematode Acetylcholinesterases (M. Arpagaus et al.). Structure Function Relationship: Three Dimensional Structure of Acetylcholinesterase (J.L. Sussman et al.) Structural Analysis of Acetylcholinesterase Ammonium Binding Sites (I. Schalk et al.). Structural Investigations of Acetylcholinesterase (F. Hucho et al.). Physiological Role and Clinical Applications: Factors Influencing Acetylcholinesterase Regulation in Slow and Fast Skeletal Muscles (J. Sketelj et al.). Towards a Functional Analysis of Cholinesterases in Neurogenesis (P.G. Layer). Acetylcholinesterase as a Modulatory Neuroprotein and its Influence on Motor Control (S.A. Greenfield). 28 additional articles. Index.

Product Details

ISBN-13:	9780306443152
Publisher:	Springer-Verlag New York, LLC
Publication date:	01/28/1993
Pages:	310
Product dimensions:	7.00(w) x 10.00(h) x 0.75(d)

Table of Contents

Molecular Polymorphism: Biosynthesis of the Molecular Forms of Acetylcholinesterase (J. Massoulie et al.). Molecular Organization of Recombinant Human Acetylcholinesterase (B. Velan et al.). Nematode Acetylcholinesterases (M. Arpagaus et al.). Structure Function Relationship: Three Dimensional Structure of Acetylcholinesterase (J.L. Sussman et al.) Structural Analysis of Acetylcholinesterase Ammonium Binding Sites (I. Schalk et al.). Structural Investigations of Acetylcholinesterase (F. Hucho et al.). Physiological Role and Clinical Applications: Factors Influencing Acetylcholinesterase Regulation in Slow and Fast Skeletal Muscles (J. Sketelj et al.). Towards a Functional Analysis of Cholinesterases in Neurogenesis (P.G. Layer). Acetylcholinesterase as a Modulatory Neuroprotein and its Influence on Motor Control (S.A. Greenfield). 28 additional articles. Index.

Editorial Reviews

Inhibitors of cholinesterases have important applications in agricultural pest control, and in the medical treatment of myasthenia gravis and glaucoma, and the management of Alzheimer's disease. From an April 1992 conference in Eilat, Israel, 38 papers capture the burst of research brought about by the recent structural resolution of the catalytic subunit of acetylcholinesterase and by the application of methodologies related to molecular genetics and protein engineering. The general topics are molecular polymorphism, structure-function relationships, the physiological role, and clinical applications. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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