Molecular Neurosurgery with Targeted Toxins / Edition 1

by Ronald G. Wiley, Douglas A. Lappi

Overview

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

Product Details

ISBN-13:	9781588291998
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/22/2005
Edition description:	2005
Pages:	312
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

to Molecular Neurosurgery.- Ribosome-Inactivating Proteins.- Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG-Saporin.- Basal Forebrain Cholinergic Lesion by 192 IgG-Saporin.- 192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System.- Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG-Saporin.- Cortical Cholinergic Deafferentation Induces A? Deposition.- Chemical Dissection of Brain Glucoregulatory Circuitry.- Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin-Based Immunotoxin.- Saporin Conjugates and Pain.- The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness.- Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons.- B Fragment of Cholera Toxin Conjugated to Saporin.

Editorial Reviews

Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: Molecular biology has been contributing to the development of newer medications and targeted drugs for the nervous system. This book addresses new avenues of treatment in neurosurgery with targeted drugs.
Purpose: The purpose is to integrate the concepts derived from targeted lesions and stimulation to the central nervous system and different drugs developed from previous decades of research.
Audience: Neurologists, neuroscientists, and neurosurgeons are the main audience for this book.
Features: Multiple contributors wrote the 13 chapters. Although mostly dedicated to the basic sciences, this book addresses multiple potential clinical applications of the targeted research being developed. The pictures are well chosen and the text, easy to follow. The price is a bit too high but encompasses the years of research devoted by the authors and contributors.
Assessment: This is a good purchase for most neuroscience and neurology libraries. It is less appropriate for neurosurgical libraries.

Doody's Review Service

"...a good purchase for most neuroscience and neurology libraries." - Doody's Health Science Book Review Journal

From the Publisher

3 Stars from Doody