Molecular Genetics of Sex Determination

by Stephen S. Wachtel (Editor)

Overview

In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation.

With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students.

• Reviews the genetics of sex determination in 19 up-to-date chapters
• Features research on sex chromosomes and sex-determining genes
• Includes abnormalities of sex determination and clinical genetics
• Written by scientists who pioneered work in this field

Product Details

ISBN-13:	9781483295589
Publisher:	Elsevier Science
Publication date:	07/23/2014
Sold by:	Barnes & Noble
Format:	eBook
Pages:	518
File size:	9 MB

Table of Contents

Part I:
S.S. Wachtel and T.R. Tiersch, The Search for the Male Determining Gene.
A. Sinclair, The Cloning of SRY.
J. Gubbay and R. Lovell-Badge, The Mouse Y Chromosome.
A. McLaren, XX Sex Reversal in the Mouse.
C.M. Nagamine, XY Sex Reversal in the Mouse.
S. Ohno, Conservation of the X-Linkage Group in Toto by all Eutherian Mammals.
M.F. Lyon, X-Chromosome Inactivation.
G.K. Hampikian, D.W. Cooper, J.A. Marshall Graves, Sex Determination in Marsupials and Monotremes.
C. Cronmiller and H.K. Salz, The Feminine Mystique: The Initiation of Sex Determination in Drosophila.
Part II:
U. Muller, The Human Y Chromosome.
N.A. Affara and M.A. Ferguson-Smith, DNA Sequence Homology between the Human Sex Chromosomes.
S.S. Wachtel, XX Sex Reversal in the Human.
S.S. Wachtel and J.L. Simpson, XY Sex Reversal in the Human.
K.Neeley and R.G. Rosenfeld, Phenotypic Correlations of X Chromosome Loss.
L. Pinsky, M. Trifiro, L.K. Beitel, and M. Kaufman, Molecular Genetics of Androgen Insensitivity Syndromes in Man.
M. Zachmann, Male Pseudohermaphroditism.
M.I. New and C. Crawford, Molecular Genetics of Steroid 21-Hydroxylase Deficiency.
N. Josso, S. Imbeaud, J.-Y. Picard, and R.L. Cate, The Gene for Anti-Mullerian Hormone.
M.L. Gustafson and P.K. Donahoe, Mullerian Inhibiting Substance: Critical Roles in Sexual Differentiation.

Editorial Reviews

This current and authoritative volume is organized into two parts. The first includes chapters on the basic biology of sex determination and summarizes the pioneering work in mice, marsupials, and Drosophila. The second part includes chapters on human genetics and clinical aspects, and covers the various syndromes of abnormal sex differentiation. The contributors are those closest to the achievements described, e.g., Ohno on Ohno's Law, Lyon on the Lyon hypothesis, and Sinclair on cloning the SRY sex-determining gene. The articles were completed within months of publication, and the references are comprehensive and up-to-date, including the literature of 1992 and most of 1993. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

"Many of the individual contributions to this book are excellent stand-alone reviews, and the book as a whole constitutes a valuable source of information on sex determination, the X and Y chromosomes, and sexual development-bothnormal and abnormal-in humans and mice. I found the rather personal chapter by Hampikian et al. on marsupials to be particularly useful in conjunction with the Drosophila chapter; together they provide a sense of the commonalities and differences that determine sexual dimorphism in each of these groups relative to each other and to the eutherian mouse-human group." —SCIENCE

"This book contains all you ever wanted to know about mammalian sex determination but were afraid to ask!... In all honesty, this is really a very good book which will provide an invaluable source of reference." —HEREDITY

From the Publisher