Molecular Cardiology for the Cardiologists / Edition 1

by Bernard Swynghedauw

Overview

Molecular Cardiology for the Cardiologist provides a short, easily readable summary of what the new biology brings to cardiology. With this in mind, special efforts have been made to present many comprehensive schemes and drawings, as well as teaching tables.
The five parts of the book provide a general introduction to the new language of biology; the normal structure of the heart and blood vessels; the physiopathology and the new therapeutic avenues that have been opened up by the new biology.
A concise summary of the keys that assist the cardiologist or student who seeks to learn and read more about this field. Provides practical examples to illustrate the clinical interest of the new approach.

Product Details

ISBN-13:	9781461358350
Publisher:	Springer US
Publication date:	10/08/2012
Series:	Developments in Cardiovascular Medicine , #172
Edition description:	Softcover reprint of the original 1st ed. 1995
Pages:	250
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

About the Author

Swynghedauw, Bernard, PhD, MD (INSERM)

Table of Contents

1. The New Language of Biology.- From Chromosome to Gene.- Current Technologies.- 2. Normal Heart and Vessels.- Membrane Proteins and Electrical Activity.- Contractile Proteins and Contractility.- Calciproteins and Calcium Movements.- Collagen, ECM, and Tissue Compliance.- Peptides Regulating Cardiac or Vascular Function.- Cardiac and Vascular Growth.- 3. Diseases of Adaptation.- Biological Adaptation.- The Hypertrophied and Failing Heart.- The Senescent Heart and Vessels.- 4. Genetics.- DNA Polymorphism.- Inherited Diseases.- Inherited Cardiovascular Diseases and Risk Factors.- 5. Gene Transfers.- Gene Transfer during Viral Infection.- Transgenic Animals and Reverse Physiology.- Gene Therapy.- References.

Editorial Reviews

‘Dr Bernard Swynghedauw has written as sole author an important new book on molecular cardiology. He deals deftly with this oft neglected but increasingly important topic, and leads us gently through the forests of information, while giving us glimpses of what to many cardiologists are the still mysterious vistas of the molecule. The book then extends to the better known areas of cell signalling and towards the end tells us what can be learnt from the current genetic studies of rare cardiac diseases. To lighten our learning task, Bernard has provided no less than 69 figures, many of them outstanding. Furthermore, this all comes in a mere 250 pages, so that no one can complain that the task of reading the book requires too much time. I predict considerable success for this book and a second edition.'
Lionel H. Opie

From the Publisher

3 Stars from Doody

This text deals with the new language of biology, molecular structure, physiology of the normal heart, cardiac and vascular remodeling, genetics for the non-geneticist, gene therapy, and cell transplantation. The purpose is to make available a short, well-written summary of what cellular molecular biology brings to cardiology. It is an important objective since many cardiologists are trained in anatomy and physiology. The book is well written. It is intended for clinicians and primary care physicians and deals with the knowledge explosion in the cellular molecular cardiac area in the past five years or so. The book begins with definitions from mitosis and cell division to the genetic code in the Human Genome Project. The basic tools of molecular biology such as probes and oligonucleotides, restriction enzymes, and the polymerase chain reaction are described. There are many excellent tables listing membrane protein families as well as ion channels and other important areas. The text is well illustrated with black-and-white drawings so the reader can follow the text with the help of the illustrations. There is a discussion of the genetics of hyperlipidemia and a brief discussion of the use of gene therapy. An important section is a glossary of terms. This second edition is certainly worthwhile in an area that is showing such rapid development. The text represents an opportunity for clinical cardiologists to drill down to the cellular molecular area where their previous experience in education has been based on anatomy and hemodynamics. It is a worthwhile addition to the cardiac literature.

John F. Moran

This new book attempts to bridge the gap between basic science and clinical cardiology. It contains an introduction to basic molecular biology concepts and a glossary of the newly introduced words in the clinician's vocabulary. New molecular biology techniques currently in use in basic research and clinical practice are also described. The purpose is to provide an introduction to the rapidly growing field of molecular cardiology and a comprehensive approach to the new applications of the new biology in the diagnosis and possible treatment of cardiovascular diseases. Although there are other published books with the same objectives, the size of this book makes it particularly appealing to the interested reader. This publication meets the author's objectives to present the relation of cardiology and molecular biology in a concise way without compromising the content. The audience includes medical students, residents in internal medicine, and fellows in cardiovascular diseases. The interested practicing cardiovascular diseases specialist and the general practitioner will be greatly benefit in following the current scientific literature and the new developments in understanding diagnosing and treating cardiovascular diseases. This book's 250 pages are divided into 5 parts. The figures make the text easier to read and understand. A comprehensive glossary might also be considered as a vital part of the book. This is a very well written and easy to understand book covering the new insights that molecular biology provided in the understanding of the physiology and pathophysiology of the cardiovascular diseases. This book should be easily accessible as a quick and reliable reference to allinterested cardiologists.

Elias G. Eleftheriadis

For practicing and student cardiologists, explains what the new biology of the past couple of decades has brought to the field. Introduces the new language, the syntax of relationships as well as the terminology. Presents the new view of the normal structure of the heart and vessels; diseases of adaptation, including the hypertrophied and senescent heart; genetics, including DNA polymorphism and inherited diseases; and gene transfers and therapy. The translation is fairly stilted but comprehensible. Includes a glossary without pronunciation. Double spaced. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Elias G. Eleftheriadis, MD (Loyola University Stritch School of Medicine)
Description: This new book attempts to bridge the gap between basic science and clinical cardiology. It contains an introduction to basic molecular biology concepts and a glossary of the newly introduced words in the clinician's vocabulary. New molecular biology techniques currently in use in basic research and clinical practice are also described.
Purpose: The purpose is to provide an introduction to the rapidly growing field of molecular cardiology and a comprehensive approach to the new applications of the new biology in the diagnosis and possible treatment of cardiovascular diseases. Although there are other published books with the same objectives, the size of this book makes it particularly appealing to the interested reader. This publication meets the author's objectives to present the relation of cardiology and molecular biology in a concise way without compromising the content.
Audience: The audience includes medical students, residents in internal medicine, and fellows in cardiovascular diseases. The interested practicing cardiovascular diseases specialist and the general practitioner will be greatly benefit in following the current scientific literature and the new developments in understanding diagnosing and treating cardiovascular diseases.
Features: This book's 250 pages are divided into 5 parts. The figures make the text easier to read and understand. A comprehensive glossary might also be considered as a vital part of the book.
Assessment: This is a very well written and easy to understand book covering the new insights that molecular biology provided in the understanding of the physiology and pathophysiology of the cardiovascular diseases. This book should be easily accessible as a quick and reliable reference to all interested cardiologists.

Doody's Review Service