Molecular and Cellular Basis of Inflammation / Edition 1

by Charles N. Serhan, Peter A. Ward

Overview

The study of inflammation has captured the interest of scholars since the earliest recorded history. Symbols identifying the cardinal signs of inflammation were uncovered in both Sanskrit and hieroglyphics (1). Since complete appreciation of the inflammatory process is underscored by the need for knowledge at both the cellular and molecular levels, academic inquiry in the area of inflammation has led, in many respects, the foray of current biomedical research. Molecular and Cellular Basis of Inflammation represents research from the cutting edge in the broad view of inflammation. The chapters are written by experts with a multidisciplinary approach to the study of inflammatory and cellular processes, and thus include contributions form the fields of molecular biology, biochemistry, pharmacology, immunology, and pathobiology. Molecular and Cellular Basis of Inflammation was first conceived during a mini symposium sponsored by the American Society for Investigative Pathology held at FASEB in 1995 entitled "The Role of Reactive Lipids, Oxygen and Nitro­ gen Metabolites in Inflammation," at which several of the contributing authors delivered lectures. This present, much-extended volume includes leading-front descriptions of both protein and lipid mediators. The chapter devoted to the comple­ ment cascade by Ward and colleagues, as well as Chapters 3-7 and 13, provide up­ to-date descriptions of the biosynthesis, molecular biology, chemistry, and actions of both protein and lipid mediators.

Product Details

ISBN-13:	9780896035959
Publisher:	Springer-Verlag New York, LLC
Publication date:	12/09/1998
Series:	Current Inflammation Research
Edition description:	1999
Pages:	338
Product dimensions:	7.01(w) x 10.00(h) x 0.04(d)

About the Author

Serhan, Charles N. (Harvard Medical School); Ward, Peter A. (Univ of Michigan)

Table of Contents

Ch. 1. Role of Complement in Endothelial Cell Activation.- Ch. 2. Angiogenesis.- Ch. 3. Update on Arachidonic Acid Cascade: Leukotrienes and Lipoxins in Disease Models.- Ch. 4. Mutagenesis Studies of Mammalian Lipoxygenases.- Ch. 5. Lipid-Mediator-Deficient Mice in Models of Inflammation.- Ch. 6. Isoprostanes in the Assessment of Oxidant Stress In Vivo.- Ch. 7. Isoprostanes as Markers of Lipid Peroxidation in Atherosclerosis.- Ch. 8. Structure and Regulation of NADPH Oxidase of Phagocytic Leukocytes: Insights from Chronic Granulomatous Disease.- Ch. 9. Recruitment of—/? T-Cells and Other T-Cell Subsets to Sites of Inflammation.- Ch. 10. The N-Formyl Peptide Receptor: Structure, Signaling, and Disease.- Ch. 11. Pathobiology of Neutrophil Interactions with Polarized Columnar Epithelia.- Ch. 12. Adenosine and Its Receptors During Inflammation.- Ch. 13. Quantitative Studies of the Lipid Mediators of Inflammation Using Liquid Chromatography-Electrospray Mass Spectrometry.- Ch. 14. Molecular Biology of Autoimmune Arthritis.- Ch. 15. Lupus Erythematosus: The Role of Adhesion Molecules and Local Mediators.

Editorial Reviews

". . .this book provides a comprehensive description of our current knowledge of inflammation. It contains some useful figures and tables that provide the reader with a very good overview of the knowledge . . . an important read for scientists and clinicians who are interested in inflammation."-FEBS Letters

"...a book which changes the views of the inflammation!"-Cellular and Molecular Biology

From the Publisher

Contributors from the fields of molecular biology, biochemistry, pharmacology, immunology, and pathology review the role of protein and lipid mediators in inflammation; cellular processes of importance in the initiation and determination of inflammation; signal transduction events of interest in the development of potential new therapeutic targets; and drug design in inflammation. Also discussed are the disease mechanisms involved in angiogenesis, autoimmune arthritis, and lupus erythematosus; the role of isoprotanes in vascular disease and acute respiratory distress syndrome; the formation and release of reactive oxygen species by phagocytic leukocytes; and the biosynthesis, molecular biology, chemistry, and actions of protein and lipid mediators. Annotation c. by Book News, Inc., Portland, Or.

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