Modern Hematology: Biology and Clinical Management / Edition 2

by Reinhold Munker, Erhard Hiller, Jonathan Glass, Ronald Paquette

Overview

Over the past few decades the powerful methods of statistical physics and Euclidean quantum field theory have moved closer together, with common tools based on the use of path integrals. The interpretation of Euclidean field theories as particular systems of statistical physics has opened up new avenues for understanding strongly coupled quantum systems or quantum field theories at zero or finite temperatures.

Accordingly, the first chapters of this book contain a self-contained introduction to path integrals in Euclidean quantum mechanics and statistical mechanics. The resulting high-dimensional integrals can be estimated with the help of Monte Carlo simulations based on Markov processes. The most commonly used algorithms are presented in detail so as to prepare the reader for the use of high-performance computers as an “experimental” tool for this burgeoning field of theoretical physics.

Several chapters are then devoted to an introduction to simple lattice field theories and a variety of spin systems with discrete and continuous spins, where the ubiquitous Ising model serves as an ideal guide for introducing the fascinating area of phase transitions. As an alternative to the lattice formulation of quantum field theories, variants of the flexible renormalization group methods are discussed in detail. Since, according to our present-day knowledge, all fundamental interactions in nature are described by gauge theories, the remaining chapters of the book deal with gauge theories without and with matter.

This text is based on course-tested notes for graduate students and, as such, its style is essentially pedagogical, requiring only some basics of mathematics, statistical physics, and quantum field theory. Yet it also contains some more sophisticated conceptswhich may be useful to active researchers in the field. Each chapter ends with a number of problems – guiding the reader to a deeper understanding of some of the material presented in the main text – and, in most cases, also features some listings of short, useful computer programs.

Product Details

ISBN-13:	9781617376405
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2010
Series:	Contemporary Hematology , #864
Edition description:	Softcover reprint of hardcover 2nd ed. 2007
Pages:	498
Product dimensions:	5.98(w) x 9.02(h) x 0.04(d)

About the Author

Munker, Reinhold, MD (Univ of Munich); Hiller, Erhard, MD (Univ of Munich); Pacquette, Ronald, MD (UCLA)

Table of Contents

Basic Biology of Hemopoiesis.- Molecular Biology and Cytokines.- Supportive Care in Hematology.- Transplantation of Stem Cells From Bone Marrow, Peripheral Blood, and the Umbilical Cord.- Anemias.- Hemolytic Anemias.- Leukocytosis, Leukopenia, and Other Reactive Changes of Myelopoiesis.- The Myeloproliferative Syndromes.- Acute Myelogenous Leukemias.- Acute Lymphoblastic Leukemias.- Myelodysplastic Syndromes.- Aplastic Anemias.- Lymphocytosis, Lymphocytopenia, Lymphadenopathy, and Splenomegaly.- Hodgkin’s Lymphoma.- The Non-Hodgkin’s Lymphomas.- Multiple Myeloma and Related Paraproteinemias.- Congenital and Acquired Immunodeficiencies.- Infections Relevant to Hematology.- Basic Principles of Hemostasis.- Bleeding Disorders.- Thrombophilia, Thromboembolic Disease, and Antithrombotic Therapy.- Transfusion Medicine and Immunohematology.- Storage Disorders in Hematology.

Editorial Reviews

From the reviews of the second edition:

"This book works as a stand-alone text for its intended purpose of providing a practical approach for diagnosis and management. … Modern Hematology … is well-designed to accompany structured lectures, practical laboratories, and demonstrations for hematology courses for medical students, medical technologists, and others in related fields. This textbook does the job well. It also is well suited to serve as a basic reference and a means of identifying where to obtain more comprehensive or specialized information." (James R. Egner, Journal of the American Medical Association, December, 2007)

From the Publisher

3 Stars from Doody

This is a concise overview of key topics in hematology. The reviews include key elements in diagnosis and treatment of each disease. This book easily meets the authors' goal, which is to provide a compilation of all current information about common hematologic problems. This book is primarily written for the practicing physician. Students, residents/fellows, nurses, and allied health professionals will also benefit from this book. Hematologists may find it useful for a concise overview and as a starting point for more extensive reading via the reference list. This is an up-to-date compilation of key topics in hematology. The presentation is concise -- there are no wasted words. Controversial areas are touched upon without misinforming. References are easily noted. The color slides (after page 180) as well as the key diagrams (especially Fig 6.1- Hemoglobin electrophoresis) are essential. This will be an excellent book for a quick refresher and for teaching students, residents/fellows, non-hematology physicians, nurses, and allied health professionals. The color slides and illustrations place this book in a higher category than others in this area.

Lisa Boggio

Combines explanations of disease pathophysiology with practical approaches to diagnosis and management of hematologic disorders, presenting essential clinical facts concerning malignant and nonmalignant blood diseases, and detailing diagnostic methods, angiostatic drugs, scientific controversies, and treatment recommendations. Gives scientific background necessary for understanding new diagnostic and treatment methodologies and the molecular pathogenesis of many hematologic disorders. The editor is affiliated with the University of Munich, Germany. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Jessica K Altman, MD (Northwestern University Feinberg School of Medicine)
Description: This concise review of hematopoietic disorders includes information about molecular biology, diagnosis, and treatment that makes it appropriate for residents, fellows, and hematologists in practice. The prior edition was published in 2000 and, as the authors mention in their foreword, there have been significant changes in both our understanding and management of hematologic disorders necessitating a second edition.
Purpose: The purpose is to review the biology, diagnosis, and management of hematopoietic disorders. A clear review with relevant information is needed and this book meets its objectives. The topics are reviewed in concise, appropriate chapters.
Audience: It is targeted to hematologists and those interested in learning more about hematology. I think it is most appropriate for fellows. Dr. Munker is well published in the field of hematologic malignancies.
Features: Many areas of hematologic disorders are covered, from bleeding and thrombosis to leukemia and lymphoma. In addition, reactive changes are discussed, as are infections associated with hematology and some transfusion medicine. The acute myeloid leukemia section is particularly well done as are the sections on lymphoma. The tables are to the point and very helpful (for example, the treatment of aplastic anemia). The color plates are excellent; I prefer to have the color figures within the text, when feasible. The section on iron metabolism could have been better developed as there have been significant advances in the understanding of this area in the last couple of years. I would have preferred to see the references in the text (i.e., studies quoted) as opposed to just listed under suggested reading at the end of each chapter.
Assessment: This is an appropriate, to-the-point review of relevant literature on a par with the quality of the ASH educational material, but more inclusive.

Doody's Review Service